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1. (WO2007011148) A COMPOSITION COMPRISING AN EXTRACT OF TIARELLA POLYPHYLLA AND TIARELLIC ACID ISOLATED THEREFROM HAVING ANTIINFLAMMATORY, ANTIALLERGIC AND ANTIASTHMATIC ACTIVITY
Latest bibliographic data on file with the International Bureau

Pub. No.: WO/2007/011148 International Application No.: PCT/KR2006/002807
Publication Date: 25.01.2007 International Filing Date: 18.07.2006
IPC:
A61K 36/185 (2006.01) ,A23L 1/29 (2006.01)
A HUMAN NECESSITIES
61
MEDICAL OR VETERINARY SCIENCE; HYGIENE
K
PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
36
Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
18
Magnoliophyta (angiosperms)
185
Magnoliopsida (dicotyledons)
A HUMAN NECESSITIES
23
FOODS OR FOODSTUFFS; THEIR TREATMENT, NOT COVERED BY OTHER CLASSES
L
FOODS, FOODSTUFFS, OR NON-ALCOHOLIC BEVERAGES, NOT COVERED BY SUBCLASSES A21D91; THEIR PREPARATION OR TREATMENT, e.g. COOKING, MODIFICATION OF NUTRITIVE QUALITIES, PHYSICAL TREATMENT; PRESERVATION OF FOODS OR FOODSTUFFS, IN GENERAL
1
Foods or foodstuffs; Their preparation or treatment
29
Modifying nutritive qualities of foods; Dietetic products
Applicants:
KOREA RESEARCH INSTITUTE OF BIOSCIENCE AND BIOTECHNOLOGY [KR/KR]; 52, Eoeun-dong Yuseong-gu Daejeon 305-806, KR (AllExceptUS)
LEE, Hyeong Kyu [KR/KR]; KR (UsOnly)
OH, Sei Ryang [KR/KR]; KR (UsOnly)
AHN, Kyung Seop [KR/KR]; KR (UsOnly)
LEE, Joong Ku [KR/KR]; KR (UsOnly)
LEE, Sang Ku [KR/KR]; KR (UsOnly)
KIM, Jung Hee [KR/KR]; KR (UsOnly)
KIM, Doo Young [KR/KR]; KR (UsOnly)
QUAN, Gui Hua [CN/KR]; KR (UsOnly)
KWON, Ok Kyoung [KR/KR]; KR (UsOnly)
KIM, Eun Ah [KR/KR]; KR (UsOnly)
CHOI, Soon Ja [KR/KR]; KR (UsOnly)
SHEN, Guang Hai [CN/KR]; KR (UsOnly)
KIM, Mi Jin [KR/KR]; KR (UsOnly)
PARK, Bo Young [KR/KR]; KR (UsOnly)
MIN, Byung Sun [KR/KR]; KR (UsOnly)
HAN, Gyoon Hee [KR/KR]; KR (UsOnly)
PARK, Hea Young [KR/KR]; KR (UsOnly)
KIM, Gun Cheol [KR/KR]; KR (UsOnly)
KIM, Joo Heon [KR/KR]; KR (UsOnly)
KIM, So Young [KR/KR]; KR (UsOnly)
Inventors:
LEE, Hyeong Kyu; KR
OH, Sei Ryang; KR
AHN, Kyung Seop; KR
LEE, Joong Ku; KR
LEE, Sang Ku; KR
KIM, Jung Hee; KR
KIM, Doo Young; KR
QUAN, Gui Hua; KR
KWON, Ok Kyoung; KR
KIM, Eun Ah; KR
CHOI, Soon Ja; KR
SHEN, Guang Hai; KR
KIM, Mi Jin; KR
PARK, Bo Young; KR
MIN, Byung Sun; KR
HAN, Gyoon Hee; KR
PARK, Hea Young; KR
KIM, Gun Cheol; KR
KIM, Joo Heon; KR
KIM, So Young; KR
Agent:
SHIN, Dong In; D.I. International Patent Office 501, Dong Seo Bldg., #1451-30 Seocho-dong, Seocho-gu Seoul 137-070, KR
Priority Data:
10-2005-006466818.07.2005KR
10-2005-006466918.07.2005KR
10-2006-006686118.07.2006KR
10-2006-006686618.07.2006KR
Title (EN) A COMPOSITION COMPRISING AN EXTRACT OF TIARELLA POLYPHYLLA AND TIARELLIC ACID ISOLATED THEREFROM HAVING ANTIINFLAMMATORY, ANTIALLERGIC AND ANTIASTHMATIC ACTIVITY
(FR) COMPOSITION COMPRENANT UN EXTRAIT DE TIARELLA POLYPHYLLA ET ACIDE TIARELLIQUE ISOLE A PARTIR DE CELUI-CI PRESENTANT UNE ACTIVITE ANTI-INFLAMMATOIRE, ANTIALLERGIQUE ET ANTIASTHMATIQUE
Abstract:
(EN) The present invention relates to a composition comprising an extract of Tiarella polyphylla, and tiarellic acid isolated therefrom having anti-inflammatory, anti-allergic and anti-asthmatic activity. The extract of Tiarella polyphylla and the tiarellic acid isolated therefrom shows the inhibitory effect on the LTC4 release in vitro test and the suppressive effect on the IgE level and the cytokine(IL-4, IL-5 and IL- 13) production, airway hyperresponsiveness, and leukocyte infiltration in OVA-induced asthmatic mice. Therefore, it can be used as the therapeutics or functional health food for treating and preventing inflammatory, allergic and asthmatic disease.
(FR) La présente invention concerne une composition comprenant un extrait de Tiarella polyphylla, et de l'acide tiarellique isolé à partir de celui-ci, présentant une activité anti-inflammatoire, anti-allergique et anti-asthmatique. L'extrait de Tiarella polyphylla et l'acide tiarellique isolé à partir de celui-ci présentent un effet inhibiteur sur la libération de LTC4 en test in vitro et un effet suppressif sur le taux d'IgE et la production de cytokine(IL-4, IL-5 et IL- 13), l'hyperréactivité bronchique, et l'infiltration de leucocytes dans une souris asthmatique ayant subi des injections d'OVA. C'est pourquoi ils peuvent être utilises en tant que produits thérapeutiques ou aliments naturels fonctionnels dans le traitement et la prévention de maladies inflammatoires, allergiques et asthmatiques.
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Designated States: AE, AG, AL, AM, AT, AU, AZ, BA, BB, BG, BR, BW, BY, BZ, CA, CH, CN, CO, CR, CU, CZ, DE, DK, DM, DZ, EC, EE, EG, ES, FI, GB, GD, GE, GH, GM, HN, HR, HU, ID, IL, IN, IS, JP, KE, KG, KM, KN, KP, KZ, LA, LC, LK, LR, LS, LT, LU, LV, LY, MA, MD, MG, MK, MN, MW, MX, MZ, NA, NG, NI, NO, NZ, OM, PG, PH, PL, PT, RO, RS, RU, SC, SD, SE, SG, SK, SL, SM, SY, TJ, TM, TN, TR, TT, TZ, UA, UG, US, UZ, VC, VN, ZA, ZM, ZW
African Regional Intellectual Property Organization (ARIPO) (BW, GH, GM, KE, LS, MW, MZ, NA, SD, SL, SZ, TZ, UG, ZM, ZW)
Eurasian Patent Organization (AM, AZ, BY, KG, KZ, MD, RU, TJ, TM)
European Patent Office (AT, BE, BG, CH, CY, CZ, DE, DK, EE, ES, FI, FR, GB, GR, HU, IE, IS, IT, LT, LU, LV, MC, NL, PL, PT, RO, SE, SI, SK, TR)
African Intellectual Property Organization (BF, BJ, CF, CG, CI, CM, GA, GN, GQ, GW, ML, MR, NE, SN, TD, TG)
Publication Language: English (EN)
Filing Language: English (EN)
Also published as:
EP1924159JP2009501787US20090148542CN101222930CA2615641AU2006270662
IN529/DELNP/2008