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Machine translation
1. (WO2007011131) STABLE CONTROLLED-RELEASE PELLET CONTAINING TOLTERODINE
Latest bibliographic data on file with the International Bureau   

Pub. No.:    WO/2007/011131    International Application No.:    PCT/KR2006/002764
Publication Date: 25.01.2007 International Filing Date: 14.07.2006
IPC:
A61K 9/22 (2006.01), A61K 9/30 (2006.01)
Applicants: CHONG KUN DANG PHARMACEUTICAL CORP. [KR/KR]; 368, Chungjungro 3-ga, Seodaemun-gu, Seoul 120-756 (KR) (For All Designated States Except US).
SHIN, Hee-Jong [KR/KR]; (KR) (For US Only).
LIM, Jong-Lae [KR/KR]; (KR) (For US Only).
NAM, Koong-Kwon [KR/KR]; (KR) (For US Only)
Inventors: SHIN, Hee-Jong; (KR).
LIM, Jong-Lae; (KR).
NAM, Koong-Kwon; (KR)
Agent: LEE, Byung-Hyun; #705, New-Seoul Bldg., 828-8, Yeoksam-dong, Kangnam-gu, Seoul 135-080 (KR)
Priority Data:
10-2005-0066604 22.07.2005 KR
Title (EN) STABLE CONTROLLED-RELEASE PELLET CONTAINING TOLTERODINE
(FR) COMPRIMES STABLES A LIBERATION CONTROLEE CONTENANT DE LA TOLTERODINE
Abstract: front page image
(EN)Provided is a novel pharmaceutical composition which is capable of improving the stability over time of a drug pellet during storage and distribution of the pellet having controlled release properties. More specifically, the present invention provides a novel pharmaceutical composition which is capable of preventing moisture-induced changes in a drug release rate during storage and distribution of a drug pellet, via coating of a controlled-release pellet, particularly sustained-release pellet, comprising tolterodine, a tolterodine compound or a pharmaceutically acceptable salt thereof as a drug, with a dimethylaminoethyl methacrylate/methyl methacrylate copolymer (hereinafter, referred to as 'Eudragit E') or polyvinylacetal diethylaminoacetate (hereinafter, referred to as 'AEA') which is insoluble at a pH of 5.5 or higher.
(FR)L'invention porte sur une nouvelle composition pharmaceutique améliorant la stabilité dans le temps de comprimés de médicaments pendant leur stockage et leur libération contrôlée, et plus spécifiquement sur une nouvelle composition pharmaceutique prévenant grâce à un enrobage les variations sous l'effet de l'humidité du taux de libération lors du stockage et de la distribution d'un comprimé et plus particulièrement d'un comprimé à libération continue contenant de la toltérodine. L'invention porte également sur un composé de toltérodine ou de l'un de ses sels pharmacocompatible et d'un copolymère de diméthylaminoéthyl méthacrylate/méthyl méthacrylate (dit ci-après 'Eudragit E') ou de polyvinylacétal diéthylaminoacétate (dit ci-après 'AEA') insoluble pour un pH de 5,5 ou plus.
Designated States: AE, AG, AL, AM, AT, AU, AZ, BA, BB, BG, BR, BW, BY, BZ, CA, CH, CN, CO, CR, CU, CZ, DE, DK, DM, DZ, EC, EE, EG, ES, FI, GB, GD, GE, GH, GM, HN, HR, HU, ID, IL, IN, IS, JP, KE, KG, KM, KN, KP, KZ, LA, LC, LK, LR, LS, LT, LU, LV, LY, MA, MD, MG, MK, MN, MW, MX, MZ, NA, NG, NI, NO, NZ, OM, PG, PH, PL, PT, RO, RS, RU, SC, SD, SE, SG, SK, SL, SM, SY, TJ, TM, TN, TR, TT, TZ, UA, UG, US, UZ, VC, VN, ZA, ZM, ZW.
African Regional Intellectual Property Organization (BW, GH, GM, KE, LS, MW, MZ, NA, SD, SL, SZ, TZ, UG, ZM, ZW)
Eurasian Patent Organization (AM, AZ, BY, KG, KZ, MD, RU, TJ, TM)
European Patent Office (AT, BE, BG, CH, CY, CZ, DE, DK, EE, ES, FI, FR, GB, GR, HU, IE, IS, IT, LT, LU, LV, MC, NL, PL, PT, RO, SE, SI, SK, TR)
African Intellectual Property Organization (BF, BJ, CF, CG, CI, CM, GA, GN, GQ, GW, ML, MR, NE, SN, TD, TG).
Publication Language: English (EN)
Filing Language: Korean (KO)