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Pub. No.:    WO/2007/010946    International Application No.:    PCT/JP2006/314287
Publication Date: 25.01.2007 International Filing Date: 19.07.2006
Chapter 2 Demand Filed:    14.05.2007    
A61K 31/453 (2006.01), A61P 19/02 (2006.01), A61P 19/06 (2006.01), A61P 35/00 (2006.01), A61P 43/00 (2006.01), C07D 405/04 (2006.01)
Applicants: National University Corporation Tokyo Medical and Dental University [JP/JP]; 1-5-45, Yushima, Bunkyo-ku, Tokyo 1138510 (JP) (For All Designated States Except US).
RIKEN [JP/JP]; 2-1, Hirosawa, Wako-shi, Saitama 3510198 (JP) (For All Designated States Except US).
KOSAKA, Hitoshi [JP/JP]; (JP) (For US Only).
MIYASAKA, Nobuyuki [JP/JP]; (JP) (For US Only)
Inventors: KOSAKA, Hitoshi; (JP).
MIYASAKA, Nobuyuki; (JP)
Agent: HIROTA, Koichi; HIROTA, NAGARE & ASSOCIATES, 4th Floor, Shinjuku TR Bldg., 2-2-13, Yoyogi, Shibuya-ku, Tokyo 1510053 (JP)
Priority Data:
2005-209111 19.07.2005 JP
(JA) 滑膜細胞増殖抑制剤
Abstract: front page image
(EN)Disclosed is a synovial cell proliferation inhibitor which does not induce apoptosis or immunosuppression and can inhibit the proliferation of a synovial cell. Also disclosed is a pharmaceutical composition or therapeutic method which can treat a disease involving the synovial cell proliferation without reducing the resistance against a infection. A synovial cell proliferation inhibitor comprising at least one of flavopiridol (IUPAC name: alvocidib), which is a compound of the structural formula (1), and a pharmaceutically acceptable salt thereof as an active ingredient; a pharmaceutical composition comprising at least the synovial cell proliferation inhibitor; and a therapeutic method comprising at least administering the synovial cell proliferation inhibitor.
(FR)La présente invention concerne un inhibiteur de la prolifération de cellules synoviales qui n’induit pas d’apoptose ou d’immunosuppression et est capable d’inhiber la prolifération d’une cellule synoviale. L’invention concerne aussi une composition pharmaceutique ou un procédé thérapeutique capable de traiter une maladie impliquant une prolifération de cellules synoviales, sans pour autant réduire la résistance vis-à-vis d’une infection. L’invention décrit un inhibiteur de la prolifération de cellules synoviales comprenant au moins un flavopiridol (dénomination IUPAC : alvocidib), qui est un composé de formule structurale (1), ainsi qu’un sel pharmaceutiquement acceptable de celui-ci en tant que principe actif ; une composition pharmaceutique comprenant au moins ledit inhibiteur de la prolifération de cellules synoviales; et un procédé thérapeutique comprenant au moins l’administration de l’inhibiteur de la prolifération de cellules synoviales.
(JA)not available
Designated States: AE, AG, AL, AM, AT, AU, AZ, BA, BB, BG, BR, BW, BY, BZ, CA, CH, CN, CO, CR, CU, CZ, DE, DK, DM, DZ, EC, EE, EG, ES, FI, GB, GD, GE, GH, GM, HN, HR, HU, ID, IL, IN, IS, JP, KE, KG, KM, KN, KP, KR, KZ, LA, LC, LK, LR, LS, LT, LU, LV, LY, MA, MD, MG, MK, MN, MW, MX, MZ, NA, NG, NI, NO, NZ, OM, PG, PH, PL, PT, RO, RS, RU, SC, SD, SE, SG, SK, SL, SM, SY, TJ, TM, TN, TR, TT, TZ, UA, UG, US, UZ, VC, VN, ZA, ZM, ZW.
African Regional Intellectual Property Organization (BW, GH, GM, KE, LS, MW, MZ, NA, SD, SL, SZ, TZ, UG, ZM, ZW)
Eurasian Patent Organization (AM, AZ, BY, KG, KZ, MD, RU, TJ, TM)
European Patent Office (AT, BE, BG, CH, CY, CZ, DE, DK, EE, ES, FI, FR, GB, GR, HU, IE, IS, IT, LT, LU, LV, MC, NL, PL, PT, RO, SE, SI, SK, TR)
African Intellectual Property Organization (BF, BJ, CF, CG, CI, CM, GA, GN, GQ, GW, ML, MR, NE, SN, TD, TG).
Publication Language: Japanese (JA)
Filing Language: Japanese (JA)