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1. (WO2007010838) PROCESS FOR PRODUCING ALKALINE EARTH METAL SALT OF (-)-HYDROXYCITRIC ACID
Latest bibliographic data on file with the International Bureau

Pub. No.: WO/2007/010838 International Application No.: PCT/JP2006/314024
Publication Date: 25.01.2007 International Filing Date: 14.07.2006
IPC:
C07C 51/41 (2006.01) ,C07C 59/245 (2006.01) ,C07D 307/33 (2006.01)
C CHEMISTRY; METALLURGY
07
ORGANIC CHEMISTRY
C
ACYCLIC OR CARBOCYCLIC COMPOUNDS
51
Preparation of carboxylic acids or their salts, halides, or anhydrides
41
Preparation of salts of carboxylic acids by conversion of the acids or their salts into salts with the same carboxylic acid part
C CHEMISTRY; METALLURGY
07
ORGANIC CHEMISTRY
C
ACYCLIC OR CARBOCYCLIC COMPOUNDS
59
Compounds having carboxyl groups bound to acyclic carbon atoms and containing any of the groups OH, O-metal, -CHO, keto, ether, groups, groups, or groups
235
Saturated compounds having more than one carboxyl group
245
containing hydroxy or O-metal groups
C CHEMISTRY; METALLURGY
07
ORGANIC CHEMISTRY
D
HETEROCYCLIC COMPOUNDS
307
Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom
02
not condensed with other rings
26
having one double bond between ring members or between a ring member and a non-ring member
30
with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
32
Oxygen atoms
33
in position 2, the oxygen atom being in its keto or unsubstituted enol form
Applicants:
日本新薬株式会社 NIPPON SHINYAKU CO., LTD. [JP/JP]; 〒6018550 京都府京都市南区吉祥院西ノ庄門口町14番地 Kyoto 14, Kisshoin Nishinosho Monguchicho, Minami-ku, Kyoto-shi, Kyoto 6018550, JP (AllExceptUS)
吉川 伸仁 YOSHIKAWA, Shinji [JP/JP]; JP (UsOnly)
駒井 正一 KOMAI, Shoichi [JP/JP]; JP (UsOnly)
Inventors:
吉川 伸仁 YOSHIKAWA, Shinji; JP
駒井 正一 KOMAI, Shoichi; JP
Agent:
清水 尚人 SHIMIZU, Naoto; 〒6018550 京都府京都市南区吉祥院西ノ庄門口町14番地 日本新薬株式会社 知的財産部 Kyoto Intellectual Property Department NIPPON SHINYAKUCO., LTD. 14, Kisshoin Nishinosho Monguchicho Minami-ku, Kyoto-shi Kyoto6018550, JP
Priority Data:
2005-20725915.07.2005JP
Title (EN) PROCESS FOR PRODUCING ALKALINE EARTH METAL SALT OF (-)-HYDROXYCITRIC ACID
(FR) PROCÉDÉ SERVANT À PRODUIRE UN SEL DE MÉTAL ALCALINOTERREUX DE L'ACIDE (-)-HYDROXYCITRIQUE
(JA) (-)-ヒドロキシクエン酸のアルカリ土類金属塩の製造法
Abstract:
(EN) A novel process for producing alkaline earth metal salts of (-)-hydroxycitric acid (hereinafter referred to as “compounds (1)”)represented by the general structural formula: (1) wherein M is an alkaline earth metal. There is provided a process for producing compounds (1), comprising the steps of reacting with an extract of garcinia cambogia an alkaline earth metal oxide or alkaline earth metal hydroxide or hydroxide thereof amounting in molar ratio to 0.5 to less than 0.9 foldness of (-)-hydroxycitric acid contained in the garcinia cambogia, preferably followed by cooling, and collecting resultant deposit; and reacting the collected deposit with an alkaline earth metal salt and a base and separating the compounds (1).
(FR) Nouveau procédé servant à produire des sels de métaux alcalinoterreux de l'acide (-)-hydroxycitrique (ci-après appelés 'composés (1)') représentés par la formule de structure générale : (1) où M est un métal alcalinoterreux. L'invention concerne un procédé servant à produire des composés (1), comprenant les étapes consistant à faire réagir un extrait de Garcinia cambogia avec un oxyde de métal alcalinoterreux ou un hydroxyde de métal alcalinoterreux ou un hydroxyde de ceux-ci en proportion molaire de 0,5 à 0,9 fois la quantité d'acide (-)-hydroxycitrique contenue dans Garcinia cambogia, de préférence refroidir après cela, et recueillir le dépôt résultant ; et à faire réagir le dépôt recueilli avec un sel de métal alcalinoterreux et une base et séparer les composés (1).
(JA) 本発明は、次の一般構造式(1)で表される(-)-ヒドロキシクエン酸のアルカリ土類金属塩(以下、「化合物(1)」という。)の新規な製造法に関するものである。 [式中、Mは、アルカリ土類金属を表す。] 本発明は、ガルシニアエキスと、ガルシニアに含まれる(-)-ヒドロキシクエン酸に対してモル比で0.5倍以上0.9倍未満の範囲内のアルカリ土類金属酸化物又はアルカリ土類金属水酸化物若しくはその水酸化物とを反応させ、好ましくは冷却することにより生ずる析出物を取得する工程、及び取得された析出物に、アルカリ土類金属塩と塩基とを反応させ、化合物(1)を取得する工程を有する化合物(1)の製造法である。
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Designated States: AE, AG, AL, AM, AT, AU, AZ, BA, BB, BG, BR, BW, BY, BZ, CA, CH, CN, CO, CR, CU, CZ, DE, DK, DM, DZ, EC, EE, EG, ES, FI, GB, GD, GE, GH, GM, HN, HR, HU, ID, IL, IN, IS, JP, KE, KG, KM, KN, KP, KR, KZ, LA, LC, LK, LR, LS, LT, LU, LV, LY, MA, MD, MG, MK, MN, MW, MX, MZ, NA, NG, NI, NO, NZ, OM, PG, PH, PL, PT, RO, RS, RU, SC, SD, SE, SG, SK, SL, SM, SY, TJ, TM, TN, TR, TT, TZ, UA, UG, US, UZ, VC, VN, ZA, ZM, ZW
African Regional Intellectual Property Organization (ARIPO) (BW, GH, GM, KE, LS, MW, MZ, NA, SD, SL, SZ, TZ, UG, ZM, ZW)
Eurasian Patent Organization (AM, AZ, BY, KG, KZ, MD, RU, TJ, TM)
European Patent Office (AT, BE, BG, CH, CY, CZ, DE, DK, EE, ES, FI, FR, GB, GR, HU, IE, IS, IT, LT, LU, LV, MC, NL, PL, PT, RO, SE, SI, SK, TR)
African Intellectual Property Organization (BF, BJ, CF, CG, CI, CM, GA, GN, GQ, GW, ML, MR, NE, SN, TD, TG)
Publication Language: Japanese (JA)
Filing Language: Japanese (JA)
Also published as:
JPWO2007010838JP4998264