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1. (WO2007010723) TRYPTOPHAN DERIVATIVE AND USE THEREOF
Latest bibliographic data on file with the International Bureau

Pub. No.: WO/2007/010723 International Application No.: PCT/JP2006/312978
Publication Date: 25.01.2007 International Filing Date: 29.06.2006
IPC:
C07D 209/30 (2006.01) ,A61K 31/405 (2006.01) ,A61P 19/08 (2006.01) ,A61P 19/10 (2006.01)
C CHEMISTRY; METALLURGY
07
ORGANIC CHEMISTRY
D
HETEROCYCLIC COMPOUNDS
209
Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
02
condensed with one carbocyclic ring
04
Indoles; Hydrogenated indoles
30
with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, directly attached to carbon atoms of the hetero ring
A HUMAN NECESSITIES
61
MEDICAL OR VETERINARY SCIENCE; HYGIENE
K
PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
31
Medicinal preparations containing organic active ingredients
33
Heterocyclic compounds
395
having nitrogen as a ring hetero atom, e.g. guanethidine, rifamycins
40
having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil
403
condensed with carbocyclic rings, e.g. carbazole
404
Indoles, e.g. pindolol
405
Indole-alkanecarboxylic acids; Derivatives thereof, e.g. tryptophan, indomethacin
A HUMAN NECESSITIES
61
MEDICAL OR VETERINARY SCIENCE; HYGIENE
P
SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
19
Drugs for skeletal disorders
08
for bone diseases, e.g. rachitism, Paget's disease
A HUMAN NECESSITIES
61
MEDICAL OR VETERINARY SCIENCE; HYGIENE
P
SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
19
Drugs for skeletal disorders
08
for bone diseases, e.g. rachitism, Paget's disease
10
for osteoporosis
Applicants:
国立大学法人金沢大学 NATIONAL UNIVERSITY CORPORATION KANAZAWA UNIVERSITY [JP/JP]; 〒9201164 石川県金沢市角間町ヌ7番地 Ishikawa Nu 7, Kakumamachi, Kanazawa-shi, Ishikawa 9201164, JP (JP)
国立大学法人東京医科歯科大学 NATIONAL UNIVERSITY CORPORATION TOKYO MEDICAL AND DENTAL UNIVERSITY [JP/JP]; 〒1138510 東京都文京区湯島1丁目5番45号 Tokyo 5-45, Yushima 1-chome, Bunkyo-ku Tokyo 1138510, JP (JP)
染井 正徳 SOMEI, Masanori [JP/JP]; JP (AE, AG, AL, AM, AT, AU, AZ, BA, BB, BE, BF, BG, BJ, BR, BW, BY, BZ, CA, CF, CG, CH, CI, CM, CN, CO, CR, CU, CY, CZ, DE, DK, DM, DZ, EC, EE, EG, ES, FI, FR, GA, GB, GD, GE, GH, GM, GN, GQ, GR, GW, HN, HR, HU, ID, IE, IL, IN, IS, IT, KE, KG, KM, KN, KP, KR, KZ, LA, LC, LK, LR, LS, LT, LU, LV, LY, MA, MC, MD, MG, MK, ML, MN, MR, MW, MX, MZ, NA, NE, NG, NI, NL, NO, NZ, OM, PG, PH, PL, PT, RO, RS, RU, SC, SD, SE, SG, SI, SK, SL, SM, SN, SY, SZ, TD, TG, TJ, TM, TN, TR, TT, TZ, UA, UG, US, UZ, VC, VN, ZA, ZM, ZW)
服部 淳彦 HATTORI, Atsuhiko [JP/JP]; JP (CN, US)
鈴木 信雄 SUZUKI, Nobuo [JP/JP]; JP (CN, US)
Inventors:
染井 正徳 SOMEI, Masanori; JP
服部 淳彦 HATTORI, Atsuhiko; JP
鈴木 信雄 SUZUKI, Nobuo; JP
Agent:
平木 祐輔 HIRAKI, Yusuke; 〒1050001 東京都港区虎ノ門4丁目3番20号 神谷町MTビル19階 Tokyo Kamiya-cho MT Bldg. 19F 3-20, Toranomon 4-chome Minato-ku, Tokyo 105-0001, JP
Priority Data:
2005-20975320.07.2005JP
Title (EN) TRYPTOPHAN DERIVATIVE AND USE THEREOF
(FR) DERIVES DE TRYPTOPHANE ET UTILISATION DE CELUI-CI
(JA) トリプトファン誘導体及びその用途
Abstract:
(EN) Disclosed are: a tryptophan derivative capable of activating an ostepblast; and a therapeutic agent for osteoporpsis or osteoblast activator comprising the derivative. A compound represented by the formula (I) or a salt thereof and a therapeutic agent for osteoporpsis or osteoblast activator comprising the compound or salt: (I) wherein X represents a halogen atom; R1 represents a hydrogen atom, a substituted or unsubstituted C1-6-alkyl group, a substituted or unsubstituted C2-6-alkenyl group, a substituted or unsubstituted C2-6-alkynyl group, a substituted or unsubstituted aromatic group, a substituted or unsubstituted aralkyl group, a substituted or unsubstituted acyl group, a substituted or unsubstituted arylsulfonyl group, a substituted or unsubstituted C1-6-alkylsulfonyl group, a substituted or unsubstituted C2-7-alkoxycarbonyl group or a hydroxyl group; R2 represents a substituted or unsubstituted C1-21-alkyl group; R3, R5 and R6 independently represent a hydrogen or halogen atom; R4 represents a hydrogen atom or a substituted or unsubstituted C1-6-alkyl group; and R7 represents a hydrogen atom or a substituted or unsubstituted C1-21-hydrocarbon group.
(FR) La présente invention concerne un dérivé de tryptophane capable d’activer un ostéoblaste; ainsi qu’un agent thérapeutique pour l’ostéoporose ou un activateur d’ostéoblaste comprenant le dérivé. L’invention concerne un composé représenté par la formule (I) ou un sel de celui-ci ainsi qu’un agent thérapeutique pour l’ostéoporose ou un activateur d’ostéoblaste comprenant le composé ou le sel : (I) où X représente un atome d’halogène; R1 représente un atome d’hydrogène, un groupe alkyle substitué ou non substitué en C1-6, un groupe alcényle substitué ou non substitué en C2-6, un groupe alkynyle substitué ou non substitué en C2-6, un groupe aromatique substitué ou non substitué, un groupe aryle substitué ou non substitué, un groupe acyle substitué ou non substitué, un groupe arylsulfonyle substitué ou non substitué, un groupe alkylsulfonyle substitué ou non substitué en C1-6, un groupe alkoxycarbonyle substitué ou non substitué en C2-7 ou un groupe hydroxyle; R2 représente un groupe alkyle substitué ou non substitué en C1-21; R3, R5 et R6 représentent indépendamment un atome d’hydrogène ou d’halogène; R4 représente un atome d’hydrogène ou un groupe alkyle substitué ou non substitué en C1-6; et R7 représente un atome d’hydrogène ou un groupe hydrocarboné substitué ou non substitué en C1-21.
(JA) not available
front page image
Designated States: AE, AG, AL, AM, AT, AU, AZ, BA, BB, BG, BR, BW, BY, BZ, CA, CH, CN, CO, CR, CU, CZ, DE, DK, DM, DZ, EC, EE, EG, ES, FI, GB, GD, GE, GH, GM, HN, HR, HU, ID, IL, IN, IS, JP, KE, KG, KM, KN, KP, KR, KZ, LA, LC, LK, LR, LS, LT, LU, LV, LY, MA, MD, MG, MK, MN, MW, MX, MZ, NA, NG, NI, NO, NZ, OM, PG, PH, PL, PT, RO, RS, RU, SC, SD, SE, SG, SK, SL, SM, SY, TJ, TM, TN, TR, TT, TZ, UA, UG, US, UZ, VC, VN, ZA, ZM, ZW
African Regional Intellectual Property Organization (ARIPO) (BW, GH, GM, KE, LS, MW, MZ, NA, SD, SL, SZ, TZ, UG, ZM, ZW)
Eurasian Patent Organization (AM, AZ, BY, KG, KZ, MD, RU, TJ, TM)
European Patent Office (AT, BE, BG, CH, CY, CZ, DE, DK, EE, ES, FI, FR, GB, GR, HU, IE, IS, IT, LT, LU, LV, MC, NL, PL, PT, RO, SE, SI, SK, TR)
African Intellectual Property Organization (BF, BJ, CF, CG, CI, CM, GA, GN, GQ, GW, ML, MR, NE, SN, TD, TG)
Publication Language: Japanese (JA)
Filing Language: Japanese (JA)
Also published as:
EP1911744JPWO2007010723US20090054511CN101233105JP5070050