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1. (WO2007010692) PHARMACEUTICAL COMPOSITION FOR TREATMENT OF INFLAMMATORY BOWEL DISEASE WHICH TARGETS AT HVEM AND BTLA, AND THERAPEUTIC METHOD
Latest bibliographic data on file with the International Bureau

Pub. No.: WO/2007/010692 International Application No.: PCT/JP2006/312217
Publication Date: 25.01.2007 International Filing Date: 19.06.2006
Chapter 2 Demand Filed: 10.05.2007
IPC:
A61K 45/00 (2006.01) ,A61K 38/00 (2006.01) ,A61K 39/395 (2006.01) ,A61P 1/00 (2006.01) ,A61P 29/00 (2006.01) ,C12N 15/09 (2006.01) ,C12Q 1/68 (2006.01)
A HUMAN NECESSITIES
61
MEDICAL OR VETERINARY SCIENCE; HYGIENE
K
PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
45
Medicinal preparations containing active ingredients not provided for in groups A61K31/-A61K41/132
A HUMAN NECESSITIES
61
MEDICAL OR VETERINARY SCIENCE; HYGIENE
K
PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
38
Medicinal preparations containing peptides
A HUMAN NECESSITIES
61
MEDICAL OR VETERINARY SCIENCE; HYGIENE
K
PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
39
Medicinal preparations containing antigens or antibodies
395
Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum
A HUMAN NECESSITIES
61
MEDICAL OR VETERINARY SCIENCE; HYGIENE
P
SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
1
Drugs for disorders of the alimentary tract or the digestive system
A HUMAN NECESSITIES
61
MEDICAL OR VETERINARY SCIENCE; HYGIENE
P
SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
29
Non-central analgesic, antipyretic or antiinflammatory agents, e.g antirheumatic agents; Non-steroidal antiinflammatory drugs (NSAIDs)
C CHEMISTRY; METALLURGY
12
BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
N
MICRO-ORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICRO-ORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
15
Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
09
Recombinant DNA-technology
C CHEMISTRY; METALLURGY
12
BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
Q
MEASURING OR TESTING PROCESSES INVOLVING ENZYMES OR MICRO-ORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
1
Measuring or testing processes involving enzymes or micro-organisms; Compositions therefor; Processes of preparing such compositions
68
involving nucleic acids
Applicants:
独立行政法人科学技術振興機構 JAPAN SCIENCE AND TECHNOLOGY AGENCY [JP/JP]; 〒3320012 埼玉県川口市本町四丁目1番8号 Saitama 4-1-8 Honcho, Kawaguchi-shi, Saitama 3320012, JP (AE, AG, AL, AM, AT, AU, AZ, BA, BB, BE, BF, BG, BJ, BR, BW, BY, BZ, CA, CF, CG, CH, CI, CM, CN, CO, CR, CU, CY, CZ, DE, DK, DM, DZ, EC, EE, EG, ES, FI, FR, GA, GB, GD, GE, GH, GM, GN, GQ, GR, GW, HR, HU, ID, IE, IL, IN, IS, IT, JP, KE, KG, KM, KN, KP, KR, KZ, LA, LC, LK, LR, LS, LT, LU, LV, LY, MA, MC, MD, MG, MK, ML, MN, MR, MW, MX, MZ, NA, NE, NG, NI, NL, NO, NZ, OM, PG, PH, PL, PT, RO, RS, RU, SC, SD, SE, SG, SI, SK, SL, SM, SN, SY, SZ, TD, TG, TJ, TM, TN, TR, TT, TZ, UA, UG, UZ, VC, VN, ZA, ZM, ZW)
国立大学法人東北大学 TOHOKU UNIVERSITY [JP/JP]; 〒9808577 宮城県仙台市青葉区片平二丁目1番1号 Miyagi 1-1, Katahira 2-chome, Aoba-ku, Sendai-shi, Miyagi 9808577, JP (JP)
菅村 和夫 SUGAMURA, Kazuo [JP/JP]; JP (UsOnly)
石井 直人 ISHII, Naoto [JP/JP]; JP (UsOnly)
小野 栄夫 ONO, Masao [JP/JP]; JP (UsOnly)
村田 和子 MURATA, Kazuko [JP/JP]; JP (UsOnly)
Inventors:
菅村 和夫 SUGAMURA, Kazuo; JP
石井 直人 ISHII, Naoto; JP
小野 栄夫 ONO, Masao; JP
村田 和子 MURATA, Kazuko; JP
Agent:
阿部 正博 ABE, Masahiro; 〒2740825 千葉県船橋市前原西二丁目14番1号ダイアパレス津田沼1001号 Chiba Dia Palace Tsudanuma 1001 14-1, Maebara-nishi 2-chome Funabashi-shi, Chiba 2740825, JP
Priority Data:
2005-20792919.07.2005JP
Title (EN) PHARMACEUTICAL COMPOSITION FOR TREATMENT OF INFLAMMATORY BOWEL DISEASE WHICH TARGETS AT HVEM AND BTLA, AND THERAPEUTIC METHOD
(FR) COMPOSITION PHARMACEUTIQUE POUR LE TRAITEMENT D’UNE MALADIE INFLAMMATOIRE DE L'INTESTIN QUI VISE LE HVEM ET LE BTLA, ET MÉTHODE THÉRAPEUTIQUE
(JA) HVEM及びBTLAを標的とした炎症性腸疾患治療用医薬組成物及び治療方法
Abstract:
(EN) Disclosed are an effective therapeutic method and an effective pharmaceutical composition for an inflammatory bowel disease such as ulcerative colitis or Crohn's disease. A method for treatment of an inflammatory bowel disease such as ulcerative colitis or Crohn's disease, the method comprising reacting a BTLA receptor with its ligand (e.g., soluble HVEM) or agonist (e.g., anti-BTLA antibody) to increase the BTLA receptor signal on a T cell; and a pharmaceutical composition, particularly for the treatment of an inflammatory bowel disease, comprising a ligand or agonist of a BTLA receptor as an active ingredient.
(FR) L’invention concerne une méthode thérapeutique efficace et une composition pharmaceutique efficace pour une maladie inflammatoire de l’intestin tel que la colite ulcéreuse ou la maladie de Crohn. L’invention concerne donc une méthode de traitement d'une maladie inflammatoire de l'intestin tel que colite ulcéreuse ou la maladie de Crohn, la méthode comprenant la réaction d’un récepteur BTLA avec son ligand (par exemple, HVEM soluble) ou son agoniste (par exemple, l'anticorps anti-BTLA) pour augmenter le signal du récepteur BTLA sur une cellule T ; et une composition pharmaceutique, en particulier pour le traitement d'une maladie inflammatoire de l'intestin, qui comprend un ligand ou un agoniste d'un récepteur BTLA comme principe actif.
(JA) 本発明の目的は、潰瘍性大腸炎又はクローン病のような炎症性腸疾患に対する有効な治療方法及び医薬組成物を提供することである。 本発明は、BTLA受容体と、可溶型HVEMのようなそのリガンド又は抗BTLA抗体のようなアゴニストを反応させることにより、T細胞上のBTLA受容体シグナルを増強することによる、潰瘍性大腸炎又はクローン病のような炎症性腸疾患治療方法、並びに、BTLA受容体のリガンド又はアゴニストを有効成分として含有する、医薬組成物、特に、炎症性腸疾患治療用医薬組成物に関する。  
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Designated States: AE, AG, AL, AM, AT, AU, AZ, BA, BB, BG, BR, BW, BY, BZ, CA, CH, CN, CO, CR, CU, CZ, DE, DK, DM, DZ, EC, EE, EG, ES, FI, GB, GD, GE, GH, GM, HR, HU, ID, IL, IN, IS, JP, KE, KG, KM, KN, KP, KR, KZ, LA, LC, LK, LR, LS, LT, LU, LV, LY, MA, MD, MG, MK, MN, MW, MX, MZ, NA, NG, NI, NO, NZ, OM, PG, PH, PL, PT, RO, RS, RU, SC, SD, SE, SG, SK, SL, SM, SY, TJ, TM, TN, TR, TT, TZ, UA, UG, US, UZ, VC, VN, ZA, ZM, ZW
African Regional Intellectual Property Organization (ARIPO) (BW, GH, GM, KE, LS, MW, MZ, NA, SD, SL, SZ, TZ, UG, ZM, ZW)
Eurasian Patent Organization (AM, AZ, BY, KG, KZ, MD, RU, TJ, TM)
European Patent Office (AT, BE, BG, CH, CY, CZ, DE, DK, EE, ES, FI, FR, GB, GR, HU, IE, IS, IT, LT, LU, LV, MC, NL, PL, PT, RO, SE, SI, SK, TR)
African Intellectual Property Organization (BF, BJ, CF, CG, CI, CM, GA, GN, GQ, GW, ML, MR, NE, SN, TD, TG)
Publication Language: Japanese (JA)
Filing Language: Japanese (JA)