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Pub. No.:    WO/2007/010628    International Application No.:    PCT/JP2005/013908
Publication Date: 25.01.2007 International Filing Date: 22.07.2005
A61K 45/00 (2006.01), A61K 31/655 (2006.01), A61K 38/43 (2006.01), A61K 39/395 (2006.01), A61K 48/00 (2006.01), A61P 35/00 (2006.01), C12N 15/09 (2006.01), G01N 33/573 (2006.01)
Applicants: JAPANESE FOUNDATION FOR CANCER RESEARCH [JP/JP]; 3-10-6 Ariake, Koto-ku, Tokyo 1358550 (JP) (For All Designated States Except US).
TAKEDA PHARMACEUTICAL COMPANY LIMITED [JP/JP]; 1-1, Doshomachi 4-chome, Chuo-ku, Osaka-shi, Osaka 5410045 (JP) (For All Designated States Except US).
MASHIMA, Tetsuo [JP/JP]; (JP) (For US Only).
TSURUO, Takashi [JP/JP]; (JP) (For US Only)
Inventors: MASHIMA, Tetsuo; (JP).
TSURUO, Takashi; (JP)
Agent: KOBAYASHI, Hiroshi; c/o ABE, IKUBO & KATAYAMA Fukuoka Bldg. 9th Fl. 8-7, Yaesu 2-chome Chuo-ku, Tokyo 1040028 (JP)
Priority Data:
(JA) 癌の予防・治療剤
Abstract: front page image
(EN)A compound capable of inhibiting the activities of a protein having an amino acid sequence identical or substantially identical to the amino acid sequence depicted in SEQ ID NO:1 or a salt of the compound; a compound capable of inhibiting the expression of a gene for the protein or a salt of the compound; an antisense polynucleotide comprising a nucleotide sequence complementary or substantially complementary to the nucleotide sequence of a polynucleotide encoding the protein or a partial peptide thereof or a part of the nucleotide sequence; an antibody directed against the protein; and others. These substances are useful as prophylactic/therapeutic agents for cancer, apoptosis promoters for cancer cells or the like.
(FR)L’invention concerne un composé capable d'inhiber les activités d'une protéine ayant une séquence d'acides aminés identique ou substantiellement identique à la séquence d'acides aminés représentée dans SEQ ID NO:1 ou un sel du composé ; un composé capable d'inhiber l'expression d'un gène pour la protéine ou un sel du composé ; un polynucléotide anti-sens qui comprend une séquence de nucléotide complémentaire ou substantiellement complémentaire à la séquence de nucléotide d'un polynucléotide qui encode la protéine ou un peptide partiel de celle-ci ou une partie de la séquence de nucléotide ; un anticorps dirigé contre la protéine ; et autres. Ces substances sont utiles comme agents prophylactiques/thérapeutiques pour le cancer, comme promoteurs d'apoptose pour les cellules cancéreuses ou similaires.
Designated States: AE, AG, AL, AM, AT, AU, AZ, BA, BB, BG, BR, BW, BY, BZ, CA, CH, CN, CO, CR, CU, CZ, DE, DK, DM, DZ, EC, EE, EG, ES, FI, GB, GD, GE, GH, GM, HR, HU, ID, IL, IN, IS, JP, KE, KG, KM, KP, KR, KZ, LC, LK, LR, LS, LT, LU, LV, MA, MD, MG, MK, MN, MW, MX, MZ, NA, NG, NI, NO, NZ, OM, PG, PH, PL, PT, RO, RU, SC, SD, SE, SG, SK, SL, SM, SY, TJ, TM, TN, TR, TT, TZ, UA, UG, US, UZ, VC, VN, YU, ZA, ZM, ZW.
African Regional Intellectual Property Organization (BW, GH, GM, KE, LS, MW, MZ, NA, SD, SL, SZ, TZ, UG, ZM, ZW)
Eurasian Patent Organization (AM, AZ, BY, KG, KZ, MD, RU, TJ, TM)
European Patent Office (AT, BE, BG, CH, CY, CZ, DE, DK, EE, ES, FI, FR, GB, GR, HU, IE, IS, IT, LT, LU, LV, MC, NL, PL, PT, RO, SE, SI, SK, TR)
African Intellectual Property Organization (BF, BJ, CF, CG, CI, CM, GA, GN, GQ, GW, ML, MR, NE, SN, TD, TG).
Publication Language: Japanese (JA)
Filing Language: Japanese (JA)