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1. (WO2007010556) PROCESS FOR THE PRODUCTION OF 4-AMINO-1-HYDROXYBUTYLIDENE-1,1-BISPHOSPHONIC ACID OR SALTS THEREOF
Latest bibliographic data on file with the International Bureau   

Pub. No.:    WO/2007/010556    International Application No.:    PCT/IN2006/000255
Publication Date: 25.01.2007 International Filing Date: 18.07.2006
IPC:
C07F 9/38 (2006.01)
Applicants: LUPIN LIMITED [IN/IN]; 159, Cst Road, Kalina, Santacruz (East),, Mumbai-400 098, Maharashtra, (IN) (For All Designated States Except US).
SINGH, Girij, Pal [IN/IN]; (IN) (For US Only).
JADHAV, Harishchandra, Sambhaji [IN/IN]; (IN) (For US Only).
MADDIREDDY, Narotham, Venkata [IN/IN]; (IN) (For US Only).
SRIVASTAVA, Dhananjai [IN/IN]; (IN) (For US Only)
Inventors: SINGH, Girij, Pal; (IN).
JADHAV, Harishchandra, Sambhaji; (IN).
MADDIREDDY, Narotham, Venkata; (IN).
SRIVASTAVA, Dhananjai; (IN)
Agent: MAJUMDAR, Subhatosh; S. Majumdar & Co., 5, Harish Mukherjee Road, 700 025 Kolkata (IN)
Priority Data:
636/KOL/2005 20.07.2005 IN
Title (EN) PROCESS FOR THE PRODUCTION OF 4-AMINO-1-HYDROXYBUTYLIDENE-1,1-BISPHOSPHONIC ACID OR SALTS THEREOF
(FR) PROCEDE DE PRODUCTION D'ACIDE 4-AMINO-1-HYDROXYBUTYLIDENE-1,1-BISPHOSPHONIQUE OU SELS DE CELUI-CI
Abstract: front page image
(EN)A process is provided for the preparation of 4-amino-1-hydroxybutylidene-1,1-bisphosphonic acid or salts thereof which comprises of: (a) reacting 4-aminobutyric acid with a mixture of phosphorous acid and phosphorous trichloride in solvent selected from sulfolane, diglyme and diphenyl oxide (b) hydrolyzing the resulting reaction mixture from step (a) with water (c) recovering the said 4-amino-1-hydroxybutylidene-1,1-bisphosphonic acid or salts thereof.
(FR)L'invention concerne un procédé de préparation d'acide 4-amino-1-hydroxybutylidène-1,1-bisphosphonique ou des sels de celui-ci consistant: (a) à faire réagir de l'acide 4-aminobutyrique avec un mélange d'acide phosphoreux et de trichlorure phosphoreux dans un solvant sélectionné parmi : sulfolane, diglyme et l'oxyde de diphényle ; (b) à hydrolyser le mélange de réaction obtenu à l'étape (a) avec de l'eau ; et (c) à récupérer l'acide 4-amino-1-hydroxybutylidène-1,1-bisphosphonique ou des sels de celui-ci.
Designated States: AE, AG, AL, AM, AT, AU, AZ, BA, BB, BG, BR, BW, BY, BZ, CA, CH, CN, CO, CR, CU, CZ, DE, DK, DM, DZ, EC, EE, EG, ES, FI, GB, GD, GE, GH, GM, HN, HR, HU, ID, IL, IN, IS, JP, KE, KG, KM, KN, KP, KR, KZ, LA, LC, LK, LR, LS, LT, LU, LV, LY, MA, MD, MG, MK, MN, MW, MX, MZ, NA, NG, NI, NO, NZ, OM, PG, PH, PL, PT, RO, RS, RU, SC, SD, SE, SG, SK, SL, SM, SY, TJ, TM, TN, TR, TT, TZ, UA, UG, US, UZ, VC, VN, ZA, ZM, ZW.
African Regional Intellectual Property Organization (BW, GH, GM, KE, LS, MW, MZ, NA, SD, SL, SZ, TZ, UG, ZM, ZW)
Eurasian Patent Organization (AM, AZ, BY, KG, KZ, MD, RU, TJ, TM)
European Patent Office (AT, BE, BG, CH, CY, CZ, DE, DK, EE, ES, FI, FR, GB, GR, HU, IE, IS, IT, LT, LU, LV, MC, NL, PL, PT, RO, SE, SI, SK, TR)
African Intellectual Property Organization (BF, BJ, CF, CG, CI, CM, GA, GN, GQ, GW, ML, MR, NE, SN, TD, TG).
Publication Language: English (EN)
Filing Language: English (EN)