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1. (WO2007010546) COMPOUNDS FOR TREATMENT OF LIPASE-MEDIATED DISEASES
Latest bibliographic data on file with the International Bureau   

Pub. No.:    WO/2007/010546    International Application No.:    PCT/IN2005/000318
Publication Date: 25.01.2007 International Filing Date: 19.09.2005
IPC:
C07C 69/78 (2006.01), A61K 31/235 (2006.01), A61K 31/24 (2006.01), A61K 8/37 (2006.01), A61P 3/06 (2006.01), A61Q 19/00 (2006.01), A61Q 5/00 (2006.01), A61Q 90/00 (2009.01), C07C 205/57 (2006.01)
Applicants: RELIANCE LIFE SCIENCES PVT LTD [IN/IN]; DAKC, LSC, Plot No. R-282, TTC Area of MIDC, Rabale, Navi Mumbai 400 701, Maharashtra (IN) (For All Designated States Except US).
UPADHYAY, Shakti [IN/IN]; (IN) (For US Only).
YADAV, Raman [IN/IN]; (IN) (For US Only).
GANGAN, Vijay [IN/IN]; (IN) (For US Only).
KANEKAR, Yogesh [IN/IN]; (IN) (For US Only)
Inventors: UPADHYAY, Shakti; (IN).
YADAV, Raman; (IN).
GANGAN, Vijay; (IN).
KANEKAR, Yogesh; (IN)
Priority Data:
864/MUM/2005 21.07.2005 IN
Title (EN) COMPOUNDS FOR TREATMENT OF LIPASE-MEDIATED DISEASES
(FR) COMPOSES POUR LE TRAITEMENT DE MALADIES INDUITES PAR LA LIPASE
Abstract: front page image
(EN)Novel benzoquinone-derived compounds and polymorphs and prodrugs thereof, geometric or optical isomers thereof, and pharmaceutically acceptable esters, ethers, carbamates, oximes of such compounds, polymorphs, prodrugs and isomers are provided. Process for preparation of compounds of the invention and pharmaceutical compositions containing such compounds and active polymorphs, prodrugs, isomers or pharmaceutically acceptable salts, esters thereof and their use for reducing or inhibiting activity of lipase gene family for treatment, amelioration or prevention of lipase gene family mediated diseases and conditions including overweight, obesity, hyperlipidemia, hypercholesterolemia, hypertriglyceridemia, pancreatitis, diabetes, atherosclerosis, other cardiovascular diseases, metabolic syndromes, metabolic disorders, skin, hair, and cosmetic are provided.
(FR)La présente invention concerne de nouveaux composés dérivés de la benzoquinone ainsi que des polymorphes et promédicaments de ceux-ci, des isomères géométriques ou optiques de ceux-ci ainsi que des esters, éthers, carbamates, oximes pharmaceutiquement acceptables de ces composés, polymorphes, promédicaments et isomères. L’invention concerne la préparation de composés selon l’invention et de compositions pharmaceutiques contenant de tels composés et des polymorphes, promédicaments, isomères actifs ou sels et esters pharmaceutiquement acceptables de ceux-ci, ainsi que leur utilisation en vue de réduire ou d’inhiber l’activité de la famille génétique de la lipase pour le traitement, l’amélioration ou la prévention des maladies induites par famille génétique de la lipase et les pathologies incluant la surcharge pondérale, l’obésité, l’hyperlipidémie, l’hypercholestérolémie, l’hypertriglycéridémie, la pancréatite, le diabète, l’athérosclérose, d’autres maladies cardiovasculaires, les syndromes métaboliques, les troubles métaboliques, cutanés, les troubles des cheveux et les troubles esthétiques.
Designated States: AE, AG, AL, AM, AT, AU, AZ, BA, BB, BG, BR, BW, BY, BZ, CA, CH, CN, CO, CR, CU, CZ, DE, DK, DM, DZ, EC, EE, EG, ES, FI, GB, GD, GE, GH, GM, HR, HU, ID, IL, IN, IS, JP, KE, KG, KM, KP, KR, KZ, LC, LK, LR, LS, LT, LU, LV, LY, MA, MD, MG, MK, MN, MW, MX, MZ, NA, NG, NI, NO, NZ, OM, PG, PH, PL, PT, RO, RU, SC, SD, SE, SG, SK, SL, SM, SY, TJ, TM, TN, TR, TT, TZ, UA, UG, US, UZ, VC, VN, YU, ZA, ZM, ZW.
African Regional Intellectual Property Organization (BW, GH, GM, KE, LS, MW, MZ, NA, SD, SL, SZ, TZ, UG, ZM, ZW)
Eurasian Patent Organization (AM, AZ, BY, KG, KZ, MD, RU, TJ, TM)
European Patent Office (AT, BE, BG, CH, CY, CZ, DE, DK, EE, ES, FI, FR, GB, GR, HU, IE, IS, IT, LT, LU, LV, MC, NL, PL, PT, RO, SE, SI, SK, TR)
African Intellectual Property Organization (BF, BJ, CF, CG, CI, CM, GA, GN, GQ, GW, ML, MR, NE, SN, TD, TG).
Publication Language: English (EN)
Filing Language: English (EN)