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1. (WO2007010528) METHODS AND KITS FOR IDENTIFYING NUCLEIC ACID SEQUENCES
Latest bibliographic data on file with the International Bureau   

Pub. No.:    WO/2007/010528    International Application No.:    PCT/IL2006/000824
Publication Date: 25.01.2007 International Filing Date: 16.07.2006
IPC:
C12Q 1/68 (2006.01), C12P 19/34 (2006.01), C12N 9/00 (2006.01), C07H 21/04 (2006.01)
Applicants: YEDA RESEARCH AND DEVELOPMENT CO. LTD. [IL/IL]; At The Weizmann Institute of Science, P.O. Box 95, 76100 Rechovot (IL) (For All Designated States Except US).
STAVANS, Joel [IL/IL]; (IL) (For US Only).
SAGI, Dror [IL/IL]; (IL) (For US Only)
Inventors: STAVANS, Joel; (IL).
SAGI, Dror; (IL)
Agent: G.E. EHRLICH (1995) LTD.; 11 Menachem Begin Street, 52 521 Ramat Gan (IL)
Priority Data:
60/699,373 15.07.2005 US
Title (EN) METHODS AND KITS FOR IDENTIFYING NUCLEIC ACID SEQUENCES
(FR) PROCEDES ET KITS PERMETTANT D'IDENTIFIER DES SEQUENCES D'ACIDES NUCLEIQUES
Abstract: front page image
(EN)Methods and kits for detecting a nucleic acid sequence-of-interest in a sample are provided. The methods and kits use RecA-mediated strand exchange which is sensitive to a single-mismatch and which can exchange strands of non-denatured polynucleotide sequences of a sample. Thus the methods and kits of the present invention can be used for the identification of single nucleotide polymorphisms (SNPs), length of telomeric ends, numeration of chromosomes and disease-associated genes in a sample.
(FR)L'invention concerne des procédés et des kits permettant de détecter une séquence d'acides nucléiques étudiée dans un échantillon. Les procédés et kits mettent en oeuvre un échange de brins induit par RecA et sensible à un mauvais appariement unique et pouvant échanger des brins de séquences polynuléotidiques non dénaturées d'un échantillon. Par conséquent, les procédés et kits selon l'invention peuvent être utilisés pour l'identification de polymorphismes nucléotidiques uniques (SNP), de la longueur de terminaisons télomériques, de la numération de chromosomes et de gènes associés à des maladies dans un échantillon.
Designated States: AE, AG, AL, AM, AT, AU, AZ, BA, BB, BG, BR, BW, BY, BZ, CA, CH, CN, CO, CR, CU, CZ, DE, DK, DM, DZ, EC, EE, EG, ES, FI, GB, GD, GE, GH, GM, HN, HR, HU, ID, IL, IN, IS, JP, KE, KG, KM, KN, KP, KR, KZ, LA, LC, LK, LR, LS, LT, LU, LV, LY, MA, MD, MG, MK, MN, MW, MX, MZ, NA, NG, NI, NO, NZ, OM, PG, PH, PL, PT, RO, RS, RU, SC, SD, SE, SG, SK, SL, SM, SY, TJ, TM, TN, TR, TT, TZ, UA, UG, US, UZ, VC, VN, ZA, ZM, ZW.
African Regional Intellectual Property Organization (BW, GH, GM, KE, LS, MW, MZ, NA, SD, SL, SZ, TZ, UG, ZM, ZW)
Eurasian Patent Organization (AM, AZ, BY, KG, KZ, MD, RU, TJ, TM)
European Patent Office (AT, BE, BG, CH, CY, CZ, DE, DK, EE, ES, FI, FR, GB, GR, HU, IE, IS, IT, LT, LU, LV, MC, NL, PL, PT, RO, SE, SI, SK, TR)
African Intellectual Property Organization (BF, BJ, CF, CG, CI, CM, GA, GN, GQ, GW, ML, MR, NE, SN, TD, TG).
Publication Language: English (EN)
Filing Language: English (EN)