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1. (WO2007010525) METHODS AND COMPOSITIONS FOR IDENTIFYING A PEPTIDE HAVING AN INTERMOLECULAR INTERACTION WITH A TARGET OF INTEREST
Latest bibliographic data on file with the International Bureau

Pub. No.: WO/2007/010525 International Application No.: PCT/IL2006/000815
Publication Date: 25.01.2007 International Filing Date: 12.07.2006
IPC:
C40B 40/02 (2006.01) ,C40B 40/10 (2006.01) ,G01N 33/53 (2006.01)
C CHEMISTRY; METALLURGY
40
COMBINATORIAL TECHNOLOGY
B
COMBINATORIAL CHEMISTRY; LIBRARIES, e.g. CHEMICAL LIBRARIES, IN SILICO LIBRARIES
40
Libraries per se, e.g. arrays, mixtures
02
Libraries contained in or displayed by micro-organisms, e.g. bacteria or animal cells; Libraries contained in or displayed by vectors, e.g. plasmids; Libraries containing only micro-organisms or vectors
C CHEMISTRY; METALLURGY
40
COMBINATORIAL TECHNOLOGY
B
COMBINATORIAL CHEMISTRY; LIBRARIES, e.g. CHEMICAL LIBRARIES, IN SILICO LIBRARIES
40
Libraries per se, e.g. arrays, mixtures
04
Libraries containing only organic compounds
10
Libraries containing peptides or polypeptides, or derivatives thereof
G PHYSICS
01
MEASURING; TESTING
N
INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
33
Investigating or analysing materials by specific methods not covered by groups G01N1/-G01N31/131
48
Biological material, e.g. blood, urine; Haemocytometers
50
Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
53
Immunoassay; Biospecific binding assay; Materials therefor
Applicants:
AEBI LTD. [IL/IL]; 9 Hamazmera St. P.o.box 4010 70400 Nes Zionna, IL (AllExceptUS)
MORAD, Ilan [IL/IL]; IL (UsOnly)
ITZHAKI, Hanan [IL/IL]; IL (UsOnly)
Inventors:
MORAD, Ilan; IL
ITZHAKI, Hanan; IL
Agent:
PEARL COHEN ZEDEK LATZER ; 5 Shenkar Street P.o.box 12704 46733 Herzlia, IL
Priority Data:
60/701,09221.07.2005US
Title (EN) METHODS AND COMPOSITIONS FOR IDENTIFYING A PEPTIDE HAVING AN INTERMOLECULAR INTERACTION WITH A TARGET OF INTEREST
(FR) PROCEDES ET COMPOSITIONS D'IDENTIFICATION D'UN PEPTIDE AYANT UNE INTERACTION INTERMOLECULAIRE AVEC UNE CIBLE D'INTERET
Abstract:
(EN) This invention provides, in one embodiment, a recombinant virus or a recombinant virus library wherein each virus comprises a protein involved in viral attachment or infection, a polypeptide which differs by at least a single amino acid from another peptide or polypeptide in the library, and a modified cleavage site that is proximal to the peptide and the protein, wherein the cleavage site is modified such that a compound mediating cleavage has a reduced binding affinity for it as compared to a non-modified cleavage site. The invention further provides a target of interest complex comprising a protease, a target of interest involved in an intermolecular interaction, and a flexible linker that attaches the protease and target of interest. The invention further provides uses thereof, including a method for identifying a peptide which has an intermolecular interaction with a target of interest or identifying the agonistic or antagonistic feature of a peptide that has an intermolecular reaction with a target of interest.
(FR) L'invention concerne, dans un mode de réalisation, un virus recombinant ou une bibliothèque de virus recombinants. Chaque virus comprend une protéine impliquée dans une fixation ou infection virale, un polypeptide qui diffère par au moins un acide aminé simple d'un autre peptide ou polypeptide dans la bibliothèque, et un site de clivage modifié à proximité du peptide et de la protéine, ledit site de clivage étant modifié de façon qu'un clivage à composé intercalaire présente une affinité de liaison réduite comparé à un site de clivage non modifié. L'invention concerne en outre une cible d'un complexe d'intérêt comprenant une protéase, une cible d'intérêt impliquée dans une interaction intermoléculaire, et un lieur souple qui se fixe à la protéase et la cible d'intérêt. L'invention concerne également les utilisations associées, y compris un procédé permettant d'identifier un peptide qui a une interaction intermoléculaire avec une cible d'intérêt ou pour identifier la caractéristique agoniste ou antagoniste d'un peptide présentant une réaction intermoléculaire avec une cible d'intérêt.
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Designated States: AE, AG, AL, AM, AT, AU, AZ, BA, BB, BG, BR, BW, BY, BZ, CA, CH, CN, CO, CR, CU, CZ, DE, DK, DM, DZ, EC, EE, EG, ES, FI, GB, GD, GE, GH, GM, HN, HR, HU, ID, IL, IN, IS, JP, KE, KG, KM, KN, KP, KR, KZ, LA, LC, LK, LR, LS, LT, LU, LV, LY, MA, MD, MG, MK, MN, MW, MX, MZ, NA, NG, NI, NO, NZ, OM, PG, PH, PL, PT, RO, RS, RU, SC, SD, SE, SG, SK, SL, SM, SY, TJ, TM, TN, TR, TT, TZ, UA, UG, US, UZ, VC, VN, ZA, ZM, ZW
African Regional Intellectual Property Organization (ARIPO) (BW, GH, GM, KE, LS, MW, MZ, NA, SD, SL, SZ, TZ, UG, ZM, ZW)
Eurasian Patent Organization (AM, AZ, BY, KG, KZ, MD, RU, TJ, TM)
European Patent Office (AT, BE, BG, CH, CY, CZ, DE, DK, EE, ES, FI, FR, GB, GR, HU, IE, IS, IT, LT, LU, LV, MC, NL, PL, PT, RO, SE, SI, SK, TR)
African Intellectual Property Organization (BF, BJ, CF, CG, CI, CM, GA, GN, GQ, GW, ML, MR, NE, SN, TD, TG)
Publication Language: English (EN)
Filing Language: English (EN)
Also published as:
IL188908EP1915617US20090305898DK1915617