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1. (WO2007010398) CAVEOLIN-3 AND IN VITRO CULTURE OF HEPATITIS C VIRUS
Latest bibliographic data on file with the International Bureau

Pub. No.: WO/2007/010398 International Application No.: PCT/IB2006/002565
Publication Date: 25.01.2007 International Filing Date: 18.07.2006
IPC:
C12N 7/02 (2006.01) ,C12N 5/06 (2006.01) ,A01K 67/027 (2006.01) ,C12Q 1/70 (2006.01)
C CHEMISTRY; METALLURGY
12
BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
N
MICRO-ORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICRO-ORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
7
Viruses, e.g. bacteriophages; Compositions thereof; Preparation or purification thereof
02
Recovery or purification
(Deprecated)
C CHEMISTRY; METALLURGY
12
BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
N
MICRO-ORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICRO-ORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
5
Undifferentiated human, animal or plant cells, e.g. cell lines; Tissues; Cultivation or maintenance thereof; Culture media therefor
06
Animal cells or tissues
A HUMAN NECESSITIES
01
AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
K
ANIMAL HUSBANDRY; CARE OF BIRDS, FISHES, INSECTS; FISHING; REARING OR BREEDING ANIMALS, NOT OTHERWISE PROVIDED FOR; NEW BREEDS OF ANIMALS
67
Rearing or breeding animals, not otherwise provided for; New breeds of animals
027
New breeds of vertebrates
C CHEMISTRY; METALLURGY
12
BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
Q
MEASURING OR TESTING PROCESSES INVOLVING ENZYMES OR MICRO-ORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
1
Measuring or testing processes involving enzymes or micro-organisms; Compositions therefor; Processes of preparing such compositions
70
involving virus or bacteriophage
Applicants:
NOVARTIS VACCINES AND DIAGNOSTICS SRL [IT/IT]; Via Fiorentina 1 I-53100 Siena, IT (AllExceptUS)
MEROLA, Marcello [IT/IT]; IT (UsOnly)
CROTTA, Stefania [IT/IT]; IT (UsOnly)
BIANCHI, Alessia [IT/IT]; IT (UsOnly)
Inventors:
MEROLA, Marcello; IT
CROTTA, Stefania; IT
BIANCHI, Alessia; IT
Agent:
MARSHALL, Cameron, John; Carpmaels & Ransford 43-45 Bloomsbury Square London WC1A 2RA, GB
Priority Data:
60/700,46218.07.2005US
Title (EN) CAVEOLIN-3 AND IN VITRO CULTURE OF HEPATITIS C VIRUS
(FR) CAVEOLINE-3 ET CULTURE IN VITRO DU VIRUS DE L'HEPATITE C
Abstract:
(EN) Caveolin-3 has been identified as a cellular factor that associates with HCV protein El and E2, and is proposed as a cellular limiting factor. As an alternative possibility, caveolin-3 may act as a cellular receptor for HCV, acting alongside CD81. In either scenario, cells with increased expression of caveolin-3 will be better suited to the in vitro culture of HCV, and blocking the interaction between caveolin-3 and HCV proteins has therapeutic potential.
(FR) La cavéoline-3 a été identifiée comme étant un facteur cellulaire qui s'associe avec la protéine E1 et E2 du VHC et il a été proposé de l'utiliser en tant que facteur de limitation cellulaire. Selon une autre possibilité, la cavéoline-3 peut agir en tant que récepteur cellulaire pour le VHC, oeuvrant aux côtés de CD81. Dans les deux cas, l'expression accrue de la cavéoline-3 sera plus appropriée à la culture in vitro du VHC et le blocage de l'interaction entre la cavéoline-3 et les protéines VHC présente un potentiel thérapeutique.
front page image
Designated States: AE, AG, AL, AM, AT, AU, AZ, BA, BB, BG, BR, BW, BY, BZ, CA, CH, CN, CO, CR, CU, CZ, DE, DK, DM, DZ, EC, EE, EG, ES, FI, GB, GD, GE, GH, GM, HN, HR, HU, ID, IL, IN, IS, JP, KE, KG, KM, KN, KP, KR, KZ, LA, LC, LK, LR, LS, LT, LU, LV, LY, MA, MD, MG, MK, MN, MW, MX, MZ, NA, NG, NI, NO, NZ, OM, PG, PH, PL, PT, RO, RS, RU, SC, SD, SE, SG, SK, SL, SM, SY, TJ, TM, TN, TR, TT, TZ, UA, UG, US, UZ, VC, VN, ZA, ZM, ZW
African Regional Intellectual Property Organization (ARIPO) (BW, GH, GM, KE, LS, MW, MZ, NA, SD, SL, SZ, TZ, UG, ZM, ZW)
Eurasian Patent Organization (AM, AZ, BY, KG, KZ, MD, RU, TJ, TM)
European Patent Office (AT, BE, BG, CH, CY, CZ, DE, DK, EE, ES, FI, FR, GB, GR, HU, IE, IS, IT, LT, LU, LV, MC, NL, PL, PT, RO, SE, SI, SK, TR)
African Intellectual Property Organization (BF, BJ, CF, CG, CI, CM, GA, GN, GQ, GW, ML, MR, NE, SN, TD, TG)
Publication Language: English (EN)
Filing Language: English (EN)
Also published as:
EP1910522JP2009513109CA2615558