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1. (WO2007010390) INDAZOLECARBOXAMIDE DERIVATIVES AS 5HT4 RECEPTOR AGONISTS
Latest bibliographic data on file with the International Bureau   

Pub. No.:    WO/2007/010390    International Application No.:    PCT/IB2006/002120
Publication Date: 25.01.2007 International Filing Date: 14.07.2006
IPC:
C07D 403/12 (2006.01), C07D 401/12 (2006.01), A61K 31/435 (2006.01), A61K 31/41 (2006.01), A61P 1/00 (2006.01), A61P 9/00 (2006.01), A61P 25/06 (2006.01), A61P 25/28 (2006.01), A61P 3/10 (2006.01)
Applicants: PFIZER JAPAN INC. [JP/JP]; Shinjuku Bunka Quint Bldg., 3-22-7, Yoyogi, Shibuya-ku,, Tokyo 151-8589 (JP) (JP only).
ISHIBASHI, Asako [JP/JP]; (JP) (For US Only).
KAWAMURA, Kiyoshi [JP/JP]; (JP) (For US Only).
KATO, Tomoki [JP/JP]; (JP) (For US Only).
MIHARA, Sachiko [JP/JP]; (JP) (For US Only).
MORITA, Mikio [JP/JP]; (JP) (For US Only).
PFIZER INC. [US/US]; 235 East 42nd Street, New York, NY 10017 (US) (AE, AG, AL, AM, AT, AU, AZ, BA, BB, BE, BF, BG, BJ, BR, BW, BY, BZ, CA, CF, CG, CH, CI, CM, CN, CO, CR, CU, CY, CZ, DE, DK, DM, DZ, EC, EE, EG, ES, FI, FR, GA, GB, GD, GE, GH, GM, GN, GQ, GR, GW, HN, HR, HU, ID, IE, IL, IN, IS, IT, KE, KG, KM, KN, KP, KR, KZ, LA, LC, LK, LR, LS, LT, LU, LV, LY, MA, MC, MD, MG, MK, ML, MN, MR, MW, MX, MZ, NA, NE, NG, NI, NL, NO, NZ, OM, PG, PH, PL, PT, RO, RS, RU, SC, SD, SE, SG, SI, SK, SL, SM, SN, SY, SZ, TD, TG, TJ, TM, TN, TR, TT, TZ, UA, UG, UZ, VC, VN, ZA, ZM, ZW only)
Inventors: ISHIBASHI, Asako; (JP).
KAWAMURA, Kiyoshi; (JP).
KATO, Tomoki; (JP).
MIHARA, Sachiko; (JP).
MORITA, Mikio; (JP)
Agent: FULLER, Grover, F., Jr.,; c/o DROUIN, Stéphane, Pfizer Global Research and Development, Ramsgate Road, Sandwich, Kent CT13 9NJ (GB)
Priority Data:
60/701,691 22.07.2005 US
Title (EN) INDAZOLECARBOXAMIDE DERIVATIVES AS 5HT4 RECEPTOR AGONISTS
(FR) DERIVES D’NDAZOLECARBOXAMIDES EN TANT QU'AGONISTES DES RECEPTEURS 5HT4
Abstract: front page image
(EN)This invention relates to compounds of the formula (I): or pharmaceutically acceptable salts thereof, wherein: R1, R2, R3, A and m are each as described herein and compositions containing such compounds and the use of such compounds in the treatment of a condition mediated by 5-HT4 agonistic activity such as, but not limited to, gastroesophageal reflux disease, gastrointestinal disease, gastric motility disorder, non-ulcer dyspepsia, functional dyspepsia, irritable bowel syndrome (IBS), constipation, dyspepsia, esophagitis, gastroesophageral disease, nausea, central nervous system disease, Alzheimer's disease, cognitive disorder, emesis, migraine, neurological disease, pain, cardiovascular disorders, cardiac failure, heart arrhythmia, diabetes and apnea syndrome.
(FR)La présente invention concerne des composés de formule (I) : ou des sels pharmaceutiquement acceptables de ceux-ci, où : R1, R2, R3, A et m sont chacun tels que décrits dans le présent document, ainsi que des compositions contenant ces composés et l’utilisation de ces composés dans le traitement d’une pathologie induite par l’activité agoniste 5-HT4 telle que, sans se limiter à, le reflux gastro-oesophagien, les troubles gastro-intestinaux, les troubles de la motilité gastrique, la dyspepsie non ulcéreuse, la dyspepsie fonctionnelle, le syndrome du côlon irritable, la constipation, la dyspepsie, l’oesophagite, les maladies gastro-oesophagiennes, la nausée, les maladies du système nerveux central, la maladie d'Alzheimer, les troubles cognitifs, les vomissements, la migraine, les maladies neurologiques, la douleur, les troubles cardiovasculaires, l’insuffisance cardiaque, l’arythmie cardiaque, le diabète et le syndrome de l’apnée .
Designated States: AE, AG, AL, AM, AT, AU, AZ, BA, BB, BG, BR, BW, BY, BZ, CA, CH, CN, CO, CR, CU, CZ, DE, DK, DM, DZ, EC, EE, EG, ES, FI, GB, GD, GE, GH, GM, HN, HR, HU, ID, IL, IN, IS, JP, KE, KG, KM, KN, KP, KR, KZ, LA, LC, LK, LR, LS, LT, LU, LV, LY, MA, MD, MG, MK, MN, MW, MX, MZ, NA, NG, NI, NO, NZ, OM, PG, PH, PL, PT, RO, RS, RU, SC, SD, SE, SG, SK, SL, SM, SY, TJ, TM, TN, TR, TT, TZ, UA, UG, US, UZ, VC, VN, ZA, ZM, ZW.
African Regional Intellectual Property Organization (BW, GH, GM, KE, LS, MW, MZ, NA, SD, SL, SZ, TZ, UG, ZM, ZW)
Eurasian Patent Organization (AM, AZ, BY, KG, KZ, MD, RU, TJ, TM)
European Patent Office (AT, BE, BG, CH, CY, CZ, DE, DK, EE, ES, FI, FR, GB, GR, HU, IE, IS, IT, LT, LU, LV, MC, NL, PL, PT, RO, SE, SI, SK, TR)
African Intellectual Property Organization (BF, BJ, CF, CG, CI, CM, GA, GN, GQ, GW, ML, MR, NE, SN, TD, TG).
Publication Language: English (EN)
Filing Language: English (EN)