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1. (WO2007010285) CRYSTAL STRUCTURE OF HUMAN SOLUBLE ADENYLATE CYCLASE
Latest bibliographic data on file with the International Bureau

Pub. No.: WO/2007/010285 International Application No.: PCT/GB2006/002750
Publication Date: 25.01.2007 International Filing Date: 21.07.2006
IPC:
C12N 9/88 (2006.01) ,G01N 33/00 (2006.01)
C CHEMISTRY; METALLURGY
12
BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
N
MICRO-ORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICRO-ORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
9
Enzymes, e.g. ligases (6.); Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating, or purifying enzymes
88
Lyases (4.)
G PHYSICS
01
MEASURING; TESTING
N
INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
33
Investigating or analysing materials by specific methods not covered by groups G01N1/-G01N31/131
Applicants:
BAYER SCHERING PHARMA AKTIENGESELLSCHAFT [DE/DE]; Müllerstrasse 178 13353 Berlin, DE (AllExceptUS)
SAALAU-BETHELL, Susanne, Maria [GB/GB]; GB (UsOnly)
CLEASBY, Anne [GB/GB]; GB (UsOnly)
SAMBROOK, Tracey, Ann [GB/GB]; GB (UsOnly)
COYLE, Joseph [GB/GB]; GB (UsOnly)
VINKOVIC, Mladen [HR/GB]; GB (UsOnly)
Inventors:
SAALAU-BETHELL, Susanne, Maria; GB
CLEASBY, Anne; GB
SAMBROOK, Tracey, Ann; GB
COYLE, Joseph; GB
VINKOVIC, Mladen; GB
Agent:
BRASNETT, Adrian ; Mewburn Ellis LLP York House 23 Kingsway London Greater London WC2B 6HP, GB
Priority Data:
60/701,12221.07.2005US
Title (EN) CRYSTAL STRUCTURE OF HUMAN SOLUBLE ADENYLATE CYCLASE
(FR) STRUCTURE CRISTALLINE D'ADENYLATE CYCLASE HUMAINE SOLUBLE
Abstract:
(EN) The invention provides the crystal structure of the solAC catalytic domain. The structure is set out in Tables 1 to 5. The structure may be used in to model the interaction of ligands such as pharmaceutical compounds with this protein, and to determine the structure of related adenylate cyclase molecules.
(FR) L'invention concerne la structure cristalline du domaine catalytique solAC. Ladite structure est présentée dans les tables 1 à 5. Elle peut servir à modéliser l'interaction de ligands tels que des composés pharmaceutiques avec cette protéine, et à déterminer la structure de molécules d'adénylate cyclase connexes.
Designated States: AE, AG, AL, AM, AT, AU, AZ, BA, BB, BG, BR, BW, BY, BZ, CA, CH, CN, CO, CR, CU, CZ, DE, DK, DM, DZ, EC, EE, EG, ES, FI, GB, GD, GE, GH, GM, HN, HR, HU, ID, IL, IN, IS, JP, KE, KG, KM, KN, KP, KR, KZ, LA, LC, LK, LR, LS, LT, LU, LV, LY, MA, MD, MG, MK, MN, MW, MX, MZ, NA, NG, NI, NO, NZ, OM, PG, PH, PL, PT, RO, RS, RU, SC, SD, SE, SG, SK, SL, SM, SY, TJ, TM, TN, TR, TT, TZ, UA, UG, US, UZ, VC, VN, ZA, ZM, ZW
African Regional Intellectual Property Organization (ARIPO) (BW, GH, GM, KE, LS, MW, MZ, NA, SD, SL, SZ, TZ, UG, ZM, ZW)
Eurasian Patent Organization (AM, AZ, BY, KG, KZ, MD, RU, TJ, TM)
European Patent Office (AT, BE, BG, CH, CY, CZ, DE, DK, EE, ES, FI, FR, GB, GR, HU, IE, IS, IT, LT, LU, LV, MC, NL, PL, PT, RO, SE, SI, SK, TR)
African Intellectual Property Organization (BF, BJ, CF, CG, CI, CM, GA, GN, GQ, GW, ML, MR, NE, SN, TD, TG)
Publication Language: English (EN)
Filing Language: English (EN)
Also published as:
KR1020080036583EP1904629JP2009504141US20090275047CN101228270CA2615753
IN1406/DELNP/2008