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Pub. No.:    WO/2007/010240    International Application No.:    PCT/GB2006/002664
Publication Date: 25.01.2007 International Filing Date: 18.07.2006
G01N 33/50 (2006.01), G01N 33/53 (2006.01)
Applicants: EUROPEAN CARDIOVASCULAR GENETICS FOUNDATION [GB/GB]; Department of Haematology, University of Cambridge, Long Road, Cambridge CB2 2PT (GB) (For All Designated States Except US).
DECKMYN, Hans [BE/BE]; (BE) (For US Only).
SALLES, Isabelle [FR/BE]; (BE) (For US Only).
FONTAYNE, Alexandre [FR/FR]; (FR) (For US Only)
Inventors: DECKMYN, Hans; (BE).
SALLES, Isabelle; (BE).
FONTAYNE, Alexandre; (FR)
Agent: DAVIES, Jonathan, Mark; Reddie & Grose, 16 Theobalds Road, London WC1X 8PL (GB)
Priority Data:
0514678.2 18.07.2005 GB
Abstract: front page image
(EN)This invention relates to methods for assessing platelet activation. Such methods can be used to diagnose whether a subject has an increased risk of bleeding or thrombosis, to screen for compounds that are agonists or antagonists of platelet activation, or to screen for defective platelets. The invention provides a method for assessing platelet activation, which comprises: stimulating platelets in a platelet sample to cause activation of the platelets; capturing activated platelets from the platelet sample in preference to resting platelets; and detecting the captured activated platelets.
(FR)Procédés d'évaluation d'activation de plaquettes, utilisables pour le diagnostic de risque accru d'hémorragie ou de thrombose, l'analyse de composés agonistes ou antagonistes vis-à-vis de l'activation de plaquettes. Procédé d'évaluation de cette activation ou d'analyse de plaquettes défectueuses : stimulation de plaquettes dans un échantillon de plaquettes pour en induire l'activation ; capture des plaquettes activées à partir de l'échantillon de préférence par rapport aux plaquettes au repos ; et détection des plaquettes activées capturées.
Designated States: AE, AG, AL, AM, AT, AU, AZ, BA, BB, BG, BR, BW, BY, BZ, CA, CH, CN, CO, CR, CU, CZ, DE, DK, DM, DZ, EC, EE, EG, ES, FI, GB, GD, GE, GH, GM, HN, HR, HU, ID, IL, IN, IS, JP, KE, KG, KM, KN, KP, KR, KZ, LA, LC, LK, LR, LS, LT, LU, LV, LY, MA, MD, MG, MK, MN, MW, MX, MZ, NA, NG, NI, NO, NZ, OM, PG, PH, PL, PT, RO, RS, RU, SC, SD, SE, SG, SK, SL, SM, SY, TJ, TM, TN, TR, TT, TZ, UA, UG, US, UZ, VC, VN, ZA, ZM, ZW.
African Regional Intellectual Property Organization (BW, GH, GM, KE, LS, MW, MZ, NA, SD, SL, SZ, TZ, UG, ZM, ZW)
Eurasian Patent Organization (AM, AZ, BY, KG, KZ, MD, RU, TJ, TM)
European Patent Office (AT, BE, BG, CH, CY, CZ, DE, DK, EE, ES, FI, FR, GB, GR, HU, IE, IS, IT, LT, LU, LV, MC, NL, PL, PT, RO, SE, SI, SK, TR)
African Intellectual Property Organization (BF, BJ, CF, CG, CI, CM, GA, GN, GQ, GW, ML, MR, NE, SN, TD, TG).
Publication Language: English (EN)
Filing Language: English (EN)