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1. (WO2007010231) MODIFIED ANTIBODY FRAGMENTS
Latest bibliographic data on file with the International Bureau

Pub. No.: WO/2007/010231 International Application No.: PCT/GB2006/002649
Publication Date: 25.01.2007 International Filing Date: 17.07.2006
IPC:
C07K 16/00 (2006.01) ,A61K 47/48 (2006.01)
C CHEMISTRY; METALLURGY
07
ORGANIC CHEMISTRY
K
PEPTIDES
16
Immunoglobulins, e.g. monoclonal or polyclonal antibodies
A HUMAN NECESSITIES
61
MEDICAL OR VETERINARY SCIENCE; HYGIENE
K
PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
47
Medicinal preparations characterised by the non-active ingredients used, e.g. carriers, inert additives
48
the non-active ingredient being chemically bound to the active ingredient, e.g. polymer drug conjugates
Applicants:
UCB PHARMA S.A. [BE/BE]; 60 Allée De La Recherche B-1070 Brussels, BE (AllExceptUS)
HUMPHREYS, David, Paul [GB/GB]; GB (UsOnly)
Inventors:
HUMPHREYS, David, Paul; GB
Agent:
THOMPSON, John; UCB Celltech 208 Bath Road Slough Berkshire SL1 3WE, GB
Priority Data:
0514779.819.07.2005GB
Title (EN) MODIFIED ANTIBODY FRAGMENTS
(FR) FRAGMENTS D'ANTICORPS MODIFIES
Abstract:
(EN) The present invention relates to a new class of modified antibody fragments. The present invention provides an antibody fragment to which one or more effector molecules is attached characterized in that the native interchain disulphide bond between the heavy (CHI) and light (CL) chain constant regions is absent and the heavy chain (CHI) and light chain (CL) constant regions are linked by an interchain disulphide bond between a pair of engineered cysteines, one in the light chain constant (CL) region and the other in the heavy chain constant (CHI) region.
(FR) La présente invention concerne une nouvelle classe de fragments d’anticorps modifiés. La présente invention concerne un fragment d’anticorps auquel est attaché une ou plusieurs molécule(s) effectrice(s), caractérisé par l’absence de la liaison disulfure interchaîne native entre les régions constantes à chaînes lourdes (CHI) et légères (CL) et en ce que les régions constantes à chaînes Lourdes (CHI) et légères (CL) sont reliées par une liaison disulfure interchaîne entre une paire de cystéines obtenue par génie génétique, l’une étant située dans la région constante à chaînes légères (CL), l’autre dans la région constante à chaînes lourdes (CHI).
Designated States: AE, AG, AL, AM, AT, AU, AZ, BA, BB, BG, BR, BW, BY, BZ, CA, CH, CN, CO, CR, CU, CZ, DE, DK, DM, DZ, EC, EE, EG, ES, FI, GB, GD, GE, GH, GM, HN, HR, HU, ID, IL, IN, IS, JP, KE, KG, KM, KN, KP, KR, KZ, LA, LC, LK, LR, LS, LT, LU, LV, LY, MA, MD, MG, MK, MN, MW, MX, MZ, NA, NG, NI, NO, NZ, OM, PG, PH, PL, PT, RO, RS, RU, SC, SD, SE, SG, SK, SL, SM, SY, TJ, TM, TN, TR, TT, TZ, UA, UG, US, UZ, VC, VN, ZA, ZM, ZW
African Regional Intellectual Property Organization (ARIPO) (BW, GH, GM, KE, LS, MW, MZ, NA, SD, SL, SZ, TZ, UG, ZM, ZW)
Eurasian Patent Organization (AM, AZ, BY, KG, KZ, MD, RU, TJ, TM)
European Patent Office (AT, BE, BG, CH, CY, CZ, DE, DK, EE, ES, FI, FR, GB, GR, HU, IE, IS, IT, LT, LU, LV, MC, NL, PL, PT, RO, SE, SI, SK, TR)
African Intellectual Property Organization (BF, BJ, CF, CG, CI, CM, GA, GN, GQ, GW, ML, MR, NE, SN, TD, TG)
Publication Language: English (EN)
Filing Language: English (EN)
Also published as:
EP1913026JP2009501773ES2374222US20080269466CA2615485AU2006271416