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1. (WO2007010201) MEDICAL DEVICES AND COATINGS THEREFOR
Latest bibliographic data on file with the International Bureau

Pub. No.: WO/2007/010201 International Application No.: PCT/GB2006/002587
Publication Date: 25.01.2007 International Filing Date: 12.07.2006
IPC:
A61L 33/14 (2006.01) ,A61L 27/54 (2006.01)
A HUMAN NECESSITIES
61
MEDICAL OR VETERINARY SCIENCE; HYGIENE
L
METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION, OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS, OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS, OR SURGICAL ARTICLES
33
Antithrombogenic treatment of surgical articles, e.g. sutures, catheters, prostheses, or of articles for the manipulation or conditioning of blood; Materials for such treatment
14
Use of fibrinolytic agents or platelet aggregation inhibitors
A HUMAN NECESSITIES
61
MEDICAL OR VETERINARY SCIENCE; HYGIENE
L
METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION, OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS, OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS, OR SURGICAL ARTICLES
27
Materials for prostheses or for coating prostheses
50
Materials characterised by their function or physical properties
54
Biologically active materials, e.g. therapeutic substances
Applicants:
ASTON UNIVERSITY [GB/GB]; Business Partnership Unit Aston Triangle Birmingham B4 7ET, GB (AllExceptUS)
LAMBERT, Peter, A. [GB/GB]; GB (UsOnly)
GRIFFIN, Martin [GB/GB]; GB (UsOnly)
COLLIGHAN, Russell [GB/GB]; GB (UsOnly)
RATHBONE, Daniel, Lee [GB/GB]; GB (UsOnly)
Inventors:
LAMBERT, Peter, A.; GB
GRIFFIN, Martin; GB
COLLIGHAN, Russell; GB
RATHBONE, Daniel, Lee; GB
Agent:
BALDOCK, Sharon, Claire ; Boult Wade Tennant Verulam Gardens 70 Gray's Inn Road London WC1X 8BT, GB
Priority Data:
0515003.221.07.2005GB
Title (EN) MEDICAL DEVICES AND COATINGS THEREFOR
(FR) DISPOSITIFS MEDICAUX ET REVETEMENTS POUR CES DISPOSITIFS
Abstract:
(EN) A coating for a medical device, the device generally being of the type which is to be used internally in a subject, includes a transglutaminase (TGase) inhibitor. The Tgase inhibitor effectively prevents the activity of any Tgase involved in clot formation or clot stability. Preferably, the transglutaminase inhibitor is a factor XIIIa inhibitor. The coating may be prepared by suitable processes such as esterification. The coating may be immobilized on a suitable medical device in a number of ways and is preferably included in a TGase inhibitor containing polymer. The coating may also include a suitable antimicrobial agent.
(FR) L'invention concerne un revêtement pour dispositif médical, le dispositif médical étant généralement du type utilisable à l'intérieur d'un sujet, qui comprend un inhibiteur de la transglutaminase (TGase). L'inhibiteur de Tgase empêche effectivement l'activité d'une quelconque Tgase intervenant dans la formation d'un caillot ou la stabilité d'un caillot. De préférence, l'inhibiteur de la transglutaminase est un inhibiteur du facteur XIIIa. Le revêtement peut être préparé par des procédés appropriés, tels que l'estérification. Le revêtement, qui peut être immobilisé de différentes manières sur un dispositif médical approprié, est compris, de préférence, dans un polymère contenant l'inhibiteur de Tgase. Le revêtement peut également comprendre un agent antimicrobien approprié.
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Designated States: AE, AG, AL, AM, AT, AU, AZ, BA, BB, BG, BR, BW, BY, BZ, CA, CH, CN, CO, CR, CU, CZ, DE, DK, DM, DZ, EC, EE, EG, ES, FI, GB, GD, GE, GH, GM, HN, HR, HU, ID, IL, IN, IS, JP, KE, KG, KM, KN, KP, KR, KZ, LA, LC, LK, LR, LS, LT, LU, LV, LY, MA, MD, MG, MK, MN, MW, MX, MZ, NA, NG, NI, NO, NZ, OM, PG, PH, PL, PT, RO, RS, RU, SC, SD, SE, SG, SK, SL, SM, SY, TJ, TM, TN, TR, TT, TZ, UA, UG, US, UZ, VC, VN, ZA, ZM, ZW
African Regional Intellectual Property Organization (ARIPO) (BW, GH, GM, KE, LS, MW, MZ, NA, SD, SL, SZ, TZ, UG, ZM, ZW)
Eurasian Patent Organization (AM, AZ, BY, KG, KZ, MD, RU, TJ, TM)
European Patent Office (AT, BE, BG, CH, CY, CZ, DE, DK, EE, ES, FI, FR, GB, GR, HU, IE, IS, IT, LT, LU, LV, MC, NL, PL, PT, RO, SE, SI, SK, TR)
African Intellectual Property Organization (BF, BJ, CF, CG, CI, CM, GA, GN, GQ, GW, ML, MR, NE, SN, TD, TG)
Publication Language: English (EN)
Filing Language: English (EN)
Also published as:
EP1907027US20080299170CA2616139