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1. (WO2007010014) COMPOSITIONS FOR TREATMENT OF SYSTEMIC MASTOCYTOSIS
Latest bibliographic data on file with the International Bureau   

Pub. No.:    WO/2007/010014    International Application No.:    PCT/EP2006/064431
Publication Date: 25.01.2007 International Filing Date: 19.07.2006
IPC:
A61K 45/06 (2006.01), A61K 31/553 (2006.01), A61K 31/506 (2006.01)
Applicants: VALENT, Peter [AT/AT]; (AT)
Inventors: VALENT, Peter; (AT)
Agent: ROTH, Peter R.; Novartis AG, Corporate Intellectual Property, CH-4002 Basel (CH)
Priority Data:
60/701,098 20.07.2005 US
Title (EN) COMPOSITIONS FOR TREATMENT OF SYSTEMIC MASTOCYTOSIS
(FR) COMPOSITIONS POUR LE TRAITEMENT DE MASTOCYTOSE SYSTEMIQUE
Abstract: front page image
(EN)The present invention relates to the use of the combination of tyrosine phosphate inhibitors AMN107 and PKC412 for the preparation of a drug for the treatment of a mast cell-related proliferative disease. The present invention is also drawn to a combination treatment of a tyrosine phosphate inhibitor and a TK-inhibitor that is effective against a mast cell-related proliferative disease, including especially systemic mastocytosis (SM) including aggressive SM (ASM) and mast cell leukemia (MCL).
(FR)La présente invention concerne l'utilisation de la combinaison d'inhibiteurs de tyrosine phosphate AMN107 et PKC412 pour la préparation d'un médicament destiné au traitement d'une maladie proliférative associée aux mastocytes. La présente invention concerne également une polythérapie associant un inhibiteur de tyrosine phosphate et un inhibiteur de TK qui est efficace contre une maladie proliférative associée aux mastocytes, notamment la mastocytose systémique (SM) comprenant la SM agressive (ASM) et la leucémie à mastocytes (MCL).
Designated States: AE, AG, AL, AM, AT, AU, AZ, BA, BB, BG, BR, BW, BY, BZ, CA, CH, CN, CO, CR, CU, CZ, DE, DK, DM, DZ, EC, EE, EG, ES, FI, GB, GD, GE, GH, GM, HN, HR, HU, ID, IL, IN, IS, JP, KE, KG, KM, KN, KP, KR, KZ, LA, LC, LK, LR, LS, LT, LU, LV, LY, MA, MD, MG, MK, MN, MW, MX, MZ, NA, NG, NI, NO, NZ, OM, PG, PH, PL, PT, RO, RS, RU, SC, SD, SE, SG, SK, SL, SM, SY, TJ, TM, TN, TR, TT, TZ, UA, UG, US, UZ, VC, VN, ZA, ZM, ZW.
African Regional Intellectual Property Organization (BW, GH, GM, KE, LS, MW, MZ, NA, SD, SL, SZ, TZ, UG, ZM, ZW)
Eurasian Patent Organization (AM, AZ, BY, KG, KZ, MD, RU, TJ, TM)
European Patent Office (AT, BE, BG, CH, CY, CZ, DE, DK, EE, ES, FI, FR, GB, GR, HU, IE, IS, IT, LT, LU, LV, MC, NL, PL, PT, RO, SE, SI, SK, TR)
African Intellectual Property Organization (BF, BJ, CF, CG, CI, CM, GA, GN, GQ, GW, ML, MR, NE, SN, TD, TG).
Publication Language: English (EN)
Filing Language: English (EN)