Search International and National Patent Collections
Some content of this application is unavailable at the moment.
If this situation persists, please contact us atFeedback&Contact
1. (WO2007010007) METHOD FOR PREPARING 4&bgr;-AMINO-4'-DEMETHYL-4-DESOXYPODOPHYLLOTOXIN
Latest bibliographic data on file with the International Bureau

Pub. No.: WO/2007/010007 International Application No.: PCT/EP2006/064420
Publication Date: 25.01.2007 International Filing Date: 19.07.2006
IPC:
C07D 493/04 (2006.01)
C CHEMISTRY; METALLURGY
07
ORGANIC CHEMISTRY
D
HETEROCYCLIC COMPOUNDS
493
Heterocyclic compounds containing oxygen atoms as the only ring hetero atoms in the condensed system
02
in which the condensed system contains two hetero rings
04
Ortho-condensed systems
Applicants:
PIERRE FABRE MEDICAMENT [FR/FR]; 45, Place Abel Gance F-92100 Boulogne-Billancourt, FR (AllExceptUS)
GUMINSKI, Yves [FR/FR]; FR (UsOnly)
GROUSSEAUD, Martial [FR/FR]; FR (UsOnly)
IMBERT, Thierry [FR/FR]; FR (UsOnly)
Inventors:
GUMINSKI, Yves; FR
GROUSSEAUD, Martial; FR
IMBERT, Thierry; FR
Agent:
SCHRIMPF, WARCOIN, AHNER, TEXIER, LE FORESTIER, CALLON DE LAMARCK, COLLIN, TETAZ; Cabinet Regimbeau 20, Rue De Chazelles F-75847 Paris Cedex 17, FR
Priority Data:
050764219.07.2005FR
Title (EN) METHOD FOR PREPARING 4&bgr;-AMINO-4'-DEMETHYL-4-DESOXYPODOPHYLLOTOXIN
(FR) PROCEDE DE PREPARATION DE LA 4&bgr;-AMINO-4'-DEMETHYL-4-DESOXYPODOPHYLLOTOXINE
Abstract:
(EN) The invention relates to a method for synthesizing 4&bgr;-amino-4'-démethyl-4-desoxypodophyllotoxin of formula (1), characterized by comprising the following successive steps: a) reacting, in a pure weak acid or in a mixture consisting of acid, water and of organic solvent, without another solvent, at a temperature higher than the ambient temperature, thiourea with 4ß-halogenoacetamido-4'-demethyl-4-desoxypodophyllotoxin, and; b) recovering the 4&bgr;-amino-4'-demethyl-4-desoxypodophyllotoxin.
(FR) La présente invention concerne un procédé de synthèse de la 4&bgr;-amino-4'-déméthyl-4-desoxypodophyllotoxine de formule (1), caractérisé en ce qu'il comprend les étapes successives suivantes : a) réaction, dans un acide faible pur ou dans un mélange d'acide, d'eau et de solvant organique, sans autre solvant, à une température supérieure à la température ambiante, de la thiourée avec la 4&bgr;-halogénoacétamido-4'-déméthyl-4-desoxypodophyllotoxine ; b) récupération de la 4&bgr;-amino-4'-déméthyl-4-desoxypodophyllotoxine.
front page image
Designated States: AE, AG, AL, AM, AT, AU, AZ, BA, BB, BG, BR, BW, BY, BZ, CA, CH, CN, CO, CR, CU, CZ, DE, DK, DM, DZ, EC, EE, EG, ES, FI, GB, GD, GE, GH, GM, HN, HR, HU, ID, IL, IN, IS, JP, KE, KG, KM, KN, KP, KR, KZ, LA, LC, LK, LR, LS, LT, LU, LV, LY, MA, MD, MG, MK, MN, MW, MX, MZ, NA, NG, NI, NO, NZ, OM, PG, PH, PL, PT, RO, RS, RU, SC, SD, SE, SG, SK, SL, SM, SY, TJ, TM, TN, TR, TT, TZ, UA, UG, US, UZ, VC, VN, ZA, ZM, ZW
African Regional Intellectual Property Organization (ARIPO) (BW, GH, GM, KE, LS, MW, MZ, NA, SD, SL, SZ, TZ, UG, ZM, ZW)
Eurasian Patent Organization (AM, AZ, BY, KG, KZ, MD, RU, TJ, TM)
European Patent Office (AT, BE, BG, CH, CY, CZ, DE, DK, EE, ES, FI, FR, GB, GR, HU, IE, IS, IT, LT, LU, LV, MC, NL, PL, PT, RO, SE, SI, SK, TR)
African Intellectual Property Organization (BF, BJ, CF, CG, CI, CM, GA, GN, GQ, GW, ML, MR, NE, SN, TD, TG)
Publication Language: French (FR)
Filing Language: French (FR)
Also published as:
DZDZP2008000053NO20080812RSP-2009/0079MXMX/a/2008/000961KR1020080036058IL188716
MA29690EP1907396BRPI0613418-1ZA2008/01577JP2009501764RU02405787
US20090137826US20110021791CN101223176CA2616064PT1907396TN2008000030
NZ565923AU2006271645FR2888849DK1907396IN459/DELNP/2008