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1. (WO2007009913) PYRIDAZINONE DERIVATIVES AS THYROID HORMONE RECEPTOR AGONISTS
Latest bibliographic data on file with the International Bureau   

Pub. No.:    WO/2007/009913    International Application No.:    PCT/EP2006/064093
Publication Date: 25.01.2007 International Filing Date: 11.07.2006
IPC:
C07D 237/14 (2006.01), C07D 237/16 (2006.01), C07D 237/18 (2006.01), C07D 403/10 (2006.01), C07D 403/12 (2006.01), A61K 31/501 (2006.01), A61P 5/16 (2006.01)
Applicants: F. HOFFMANN-LA ROCHE AG [CH/CH]; Grenzacherstrasse 124, CH-4070 Basel (CH) (For All Designated States Except US).
HAYNES, Nancy-Ellen [US/US]; (US) (For US Only).
KERTESZ, Denis John [US/US]; (US) (For US Only).
PIETRANICO-COLE, Sherrie Lynn [US/US]; (US) (For US Only).
QIAN, Yimin [US/US]; (US) (For US Only).
SCOTT, Nathan Robert [US/US]; (US) (For US Only).
SO, Sung-Sau [CN/US]; (US) (For US Only).
THAKKAR, Kshitij Chhabilbhai [IN/US]; (US) (For US Only).
TILLEY, Jefferson Wright [US/US]; (US) (For US Only)
Inventors: HAYNES, Nancy-Ellen; (US).
KERTESZ, Denis John; (US).
PIETRANICO-COLE, Sherrie Lynn; (US).
QIAN, Yimin; (US).
SCOTT, Nathan Robert; (US).
SO, Sung-Sau; (US).
THAKKAR, Kshitij Chhabilbhai; (US).
TILLEY, Jefferson Wright; (US)
Agent: SALUD, Carlos; Grenzacherstrasse 124, CH-4070 Basel (CH)
Priority Data:
60/701,215 21.07.2005 US
Title (EN) PYRIDAZINONE DERIVATIVES AS THYROID HORMONE RECEPTOR AGONISTS
(FR) DERIVES DE PYRIDAZINONE UTILISES COMME AGONISTES DU RECEPTEUR DE L'HORMONE THYROIDIENNE
Abstract: front page image
(EN)Provided herein are compounds of the formula (I): as well as pharmaceutically acceptable salts thereof, wherein the substituents are as those disclosed in the specification. These compounds, and the pharmaceutical compositions containing them, are useful for the treatment of diseases such as obesity, hyperlipidemia, hypercholesterolemia and diabetes and other related disorders and diseases, and may be useful for other diseases such as NASH, atherosclerosis, cardiovascular diseases, hypothyroidism, thyroid cancer and other disorders and diseases related thereto.
(FR)L'invention concerne des composés de la formule (I) et des sels pharmaceutiquement acceptables de ces derniers, les substituants étant tels que mentionnés dans la description. Les composés précités, et les compositions pharmaceutiques les contenant, sont utilisés dans le traitement de maladies telles que l'obésité, l'hyperlipidémie, l'hypercholestérolémie et le diabète et autres affections et maladies liées, et peuvent être utilisés pour d'autres maladies telles que la stéato-hépatite non alcoolique (NASH), l'athérosclérose, les maladies cardiovasculaires, l'hypothyroïdie, le cancer de la thyroïde et autres affections et maladies liées.
Designated States: AE, AG, AL, AM, AT, AU, AZ, BA, BB, BG, BR, BW, BY, BZ, CA, CH, CN, CO, CR, CU, CZ, DE, DK, DM, DZ, EC, EE, EG, ES, FI, GB, GD, GE, GH, GM, HN, HR, HU, ID, IL, IN, IS, JP, KE, KG, KM, KN, KP, KR, KZ, LA, LC, LK, LR, LS, LT, LU, LV, LY, MA, MD, MG, MK, MN, MW, MX, MZ, NA, NG, NI, NO, NZ, OM, PG, PH, PL, PT, RO, RS, RU, SC, SD, SE, SG, SK, SL, SM, SY, TJ, TM, TN, TR, TT, TZ, UA, UG, US, UZ, VC, VN, ZA, ZM, ZW.
African Regional Intellectual Property Organization (BW, GH, GM, KE, LS, MW, MZ, NA, SD, SL, SZ, TZ, UG, ZM, ZW)
Eurasian Patent Organization (AM, AZ, BY, KG, KZ, MD, RU, TJ, TM)
European Patent Office (AT, BE, BG, CH, CY, CZ, DE, DK, EE, ES, FI, FR, GB, GR, HU, IE, IS, IT, LT, LU, LV, MC, NL, PL, PT, RO, SE, SI, SK, TR)
African Intellectual Property Organization (BF, BJ, CF, CG, CI, CM, GA, GN, GQ, GW, ML, MR, NE, SN, TD, TG).
Publication Language: English (EN)
Filing Language: English (EN)