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1. (WO2007009913) PYRIDAZINONE DERIVATIVES AS THYROID HORMONE RECEPTOR AGONISTS
Latest bibliographic data on file with the International Bureau

Pub. No.: WO/2007/009913 International Application No.: PCT/EP2006/064093
Publication Date: 25.01.2007 International Filing Date: 11.07.2006
IPC:
C07D 237/14 (2006.01) ,C07D 237/16 (2006.01) ,C07D 237/18 (2006.01) ,C07D 403/10 (2006.01) ,C07D 403/12 (2006.01) ,A61K 31/501 (2006.01) ,A61P 5/16 (2006.01)
C CHEMISTRY; METALLURGY
07
ORGANIC CHEMISTRY
D
HETEROCYCLIC COMPOUNDS
237
Heterocyclic compounds containing 1,2-diazine or hydrogenated 1,2-diazine rings
02
not condensed with other rings
06
having three double bonds between ring members or between ring members and non-ring members
10
with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
14
Oxygen atoms
C CHEMISTRY; METALLURGY
07
ORGANIC CHEMISTRY
D
HETEROCYCLIC COMPOUNDS
237
Heterocyclic compounds containing 1,2-diazine or hydrogenated 1,2-diazine rings
02
not condensed with other rings
06
having three double bonds between ring members or between ring members and non-ring members
10
with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
14
Oxygen atoms
16
Two oxygen atoms
C CHEMISTRY; METALLURGY
07
ORGANIC CHEMISTRY
D
HETEROCYCLIC COMPOUNDS
237
Heterocyclic compounds containing 1,2-diazine or hydrogenated 1,2-diazine rings
02
not condensed with other rings
06
having three double bonds between ring members or between ring members and non-ring members
10
with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
18
Sulfur atoms
C CHEMISTRY; METALLURGY
07
ORGANIC CHEMISTRY
D
HETEROCYCLIC COMPOUNDS
403
Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/167
02
containing two hetero rings
10
linked by a carbon chain containing aromatic rings
C CHEMISTRY; METALLURGY
07
ORGANIC CHEMISTRY
D
HETEROCYCLIC COMPOUNDS
403
Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/167
02
containing two hetero rings
12
linked by a chain containing hetero atoms as chain links
A HUMAN NECESSITIES
61
MEDICAL OR VETERINARY SCIENCE; HYGIENE
K
PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
31
Medicinal preparations containing organic active ingredients
33
Heterocyclic compounds
395
having nitrogen as a ring hetero atom, e.g. guanethidine, rifamycins
495
having six-membered rings with two nitrogen atoms as the only ring hetero atoms, e.g. piperazine
50
Pyridazines; Hydrogenated pyridazines
501
not condensed and containing further heterocyclic rings
A HUMAN NECESSITIES
61
MEDICAL OR VETERINARY SCIENCE; HYGIENE
P
SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
5
Drugs for disorders of the endocrine system
14
of the thyroid hormones, e.g. T3, T4
16
for decreasing, blocking or antagonising the activity of the thyroid hormones
Applicants:
F. HOFFMANN-LA ROCHE AG [CH/CH]; Grenzacherstrasse 124 CH-4070 Basel, CH (AllExceptUS)
HAYNES, Nancy-Ellen [US/US]; US (UsOnly)
KERTESZ, Denis John [US/US]; US (UsOnly)
PIETRANICO-COLE, Sherrie Lynn [US/US]; US (UsOnly)
QIAN, Yimin [US/US]; US (UsOnly)
SCOTT, Nathan Robert [US/US]; US (UsOnly)
SO, Sung-Sau [CN/US]; US (UsOnly)
THAKKAR, Kshitij Chhabilbhai [IN/US]; US (UsOnly)
TILLEY, Jefferson Wright [US/US]; US (UsOnly)
Inventors:
HAYNES, Nancy-Ellen; US
KERTESZ, Denis John; US
PIETRANICO-COLE, Sherrie Lynn; US
QIAN, Yimin; US
SCOTT, Nathan Robert; US
SO, Sung-Sau; US
THAKKAR, Kshitij Chhabilbhai; US
TILLEY, Jefferson Wright; US
Agent:
SALUD, Carlos; Grenzacherstrasse 124 CH-4070 Basel, CH
Priority Data:
60/701,21521.07.2005US
Title (EN) PYRIDAZINONE DERIVATIVES AS THYROID HORMONE RECEPTOR AGONISTS
(FR) DERIVES DE PYRIDAZINONE UTILISES COMME AGONISTES DU RECEPTEUR DE L'HORMONE THYROIDIENNE
Abstract:
(EN) Provided herein are compounds of the formula (I): as well as pharmaceutically acceptable salts thereof, wherein the substituents are as those disclosed in the specification. These compounds, and the pharmaceutical compositions containing them, are useful for the treatment of diseases such as obesity, hyperlipidemia, hypercholesterolemia and diabetes and other related disorders and diseases, and may be useful for other diseases such as NASH, atherosclerosis, cardiovascular diseases, hypothyroidism, thyroid cancer and other disorders and diseases related thereto.
(FR) L'invention concerne des composés de la formule (I) et des sels pharmaceutiquement acceptables de ces derniers, les substituants étant tels que mentionnés dans la description. Les composés précités, et les compositions pharmaceutiques les contenant, sont utilisés dans le traitement de maladies telles que l'obésité, l'hyperlipidémie, l'hypercholestérolémie et le diabète et autres affections et maladies liées, et peuvent être utilisés pour d'autres maladies telles que la stéato-hépatite non alcoolique (NASH), l'athérosclérose, les maladies cardiovasculaires, l'hypothyroïdie, le cancer de la thyroïde et autres affections et maladies liées.
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Designated States: AE, AG, AL, AM, AT, AU, AZ, BA, BB, BG, BR, BW, BY, BZ, CA, CH, CN, CO, CR, CU, CZ, DE, DK, DM, DZ, EC, EE, EG, ES, FI, GB, GD, GE, GH, GM, HN, HR, HU, ID, IL, IN, IS, JP, KE, KG, KM, KN, KP, KR, KZ, LA, LC, LK, LR, LS, LT, LU, LV, LY, MA, MD, MG, MK, MN, MW, MX, MZ, NA, NG, NI, NO, NZ, OM, PG, PH, PL, PT, RO, RS, RU, SC, SD, SE, SG, SK, SL, SM, SY, TJ, TM, TN, TR, TT, TZ, UA, UG, US, UZ, VC, VN, ZA, ZM, ZW
African Regional Intellectual Property Organization (ARIPO) (BW, GH, GM, KE, LS, MW, MZ, NA, SD, SL, SZ, TZ, UG, ZM, ZW)
Eurasian Patent Organization (AM, AZ, BY, KG, KZ, MD, RU, TJ, TM)
European Patent Office (AT, BE, BG, CH, CY, CZ, DE, DK, EE, ES, FI, FR, GB, GR, HU, IE, IS, IT, LT, LU, LV, MC, NL, PL, PT, RO, SE, SI, SK, TR)
African Intellectual Property Organization (BF, BJ, CF, CG, CI, CM, GA, GN, GQ, GW, ML, MR, NE, SN, TD, TG)
Publication Language: English (EN)
Filing Language: English (EN)
Also published as:
NO20080058RSP-2010/0527MXMX/a/2008/000818KR1020080019297IL188476AR054848
MA29731VN18104EP1919878CR36/9644BRPI0613754-7BRPI0613754
ZA2008/00405JP2009501759RU02379295ES2349131CN101228135CA2614529
PT1919878NZ565190AU2006271721DK1919878ID048.0745MYPI 20063456
TH87628IN658/DELNP/2008