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1. (WO2007009911) PYRIDO [2 , 3-D] PYRIMIDINE-2 , 4-DIAMINE COMPOUNDS AS PTPlB INHIBITORS
Latest bibliographic data on file with the International Bureau

Pub. No.: WO/2007/009911 International Application No.: PCT/EP2006/064091
Publication Date: 25.01.2007 International Filing Date: 11.07.2006
IPC:
C07D 471/04 (2006.01) ,A61P 3/00 (2006.01) ,A61K 31/519 (2006.01)
C CHEMISTRY; METALLURGY
07
ORGANIC CHEMISTRY
D
HETEROCYCLIC COMPOUNDS
471
Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/-C07D463/251
02
in which the condensed system contains two hetero rings
04
Ortho-condensed systems
A HUMAN NECESSITIES
61
MEDICAL OR VETERINARY SCIENCE; HYGIENE
P
SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
3
Drugs for disorders of the metabolism
A HUMAN NECESSITIES
61
MEDICAL OR VETERINARY SCIENCE; HYGIENE
K
PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
31
Medicinal preparations containing organic active ingredients
33
Heterocyclic compounds
395
having nitrogen as a ring hetero atom, e.g. guanethidine, rifamycins
495
having six-membered rings with two nitrogen atoms as the only ring hetero atoms, e.g. piperazine
505
Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
519
ortho- or peri-condensed with heterocyclic rings
Applicants:
F. HOFFMANN-LA ROCHE AG [CH/CH]; Grenzacherstrasse 124 CH-4070 Basel, CH (AllExceptUS)
BERTHEL, Steven, Joseph [US/US]; US (UsOnly)
CHEUNG, Adrian, Wai-Hing [CN/US]; US (UsOnly)
KIM, Kyungjin [KR/US]; US (UsOnly)
LI, Shiming [CN/US]; US (UsOnly)
THAKKAR, Kshitij, Chhabilbhai [IN/US]; US (UsOnly)
YUN, Weiya [CN/US]; US (UsOnly)
Inventors:
BERTHEL, Steven, Joseph; US
CHEUNG, Adrian, Wai-Hing; US
KIM, Kyungjin; US
LI, Shiming; US
THAKKAR, Kshitij, Chhabilbhai; US
YUN, Weiya; US
Agent:
SALUD, Carlos; Grenzacherstrasse 124 CH-4070 Basel, CH
Priority Data:
60/701,46721.07.2005US
Title (EN) PYRIDO [2 , 3-D] PYRIMIDINE-2 , 4-DIAMINE COMPOUNDS AS PTPlB INHIBITORS
(FR) COMPOSES PYRIDO [2, 3-D] PYRIMIDINE-2, 4-DIAMINE UTILISES COMME INHIBITEURS DE PTP1B
Abstract:
(EN) The present invention is concerned with compounds of formula (I) wherein R1, R2, R3, R4 and X are as described in the description and claims. The compounds are inhibitors of PTP1B. Accordingly, the compounds can be used for treating or preventing PTP-1B mediated diseases, including diabetes, obesity, and diabetes-related diseases.
(FR) La présente invention concerne des composés représentés par la formule (I) dans laquelle R1, R2, R3, R4 et X sont tels que décrits dans la description et les revendications. Lesdits composés sont des inhibiteurs de PTP1B. Ces composés peuvent être utilisés, en conséquence, dans le traitement ou la prévention des maladies médiées par PTP-1B, y compris le diabète, l'obésité, et les maladies associées au diabète.
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Designated States: AE, AG, AL, AM, AT, AU, AZ, BA, BB, BG, BR, BW, BY, BZ, CA, CH, CN, CO, CR, CU, CZ, DE, DK, DM, DZ, EC, EE, EG, ES, FI, GB, GD, GE, GH, GM, HN, HR, HU, ID, IL, IN, IS, JP, KE, KG, KM, KN, KP, KR, KZ, LA, LC, LK, LR, LS, LT, LU, LV, LY, MA, MD, MG, MK, MN, MW, MX, MZ, NA, NG, NI, NO, NZ, OM, PG, PH, PL, PT, RO, RS, RU, SC, SD, SE, SG, SK, SL, SM, SY, TJ, TM, TN, TR, TT, TZ, UA, UG, US, UZ, VC, VN, ZA, ZM, ZW
African Regional Intellectual Property Organization (ARIPO) (BW, GH, GM, KE, LS, MW, MZ, NA, SD, SL, SZ, TZ, UG, ZM, ZW)
Eurasian Patent Organization (AM, AZ, BY, KG, KZ, MD, RU, TJ, TM)
European Patent Office (AT, BE, BG, CH, CY, CZ, DE, DK, EE, ES, FI, FR, GB, GR, HU, IE, IS, IT, LT, LU, LV, MC, NL, PL, PT, RO, SE, SI, SK, TR)
African Intellectual Property Organization (BF, BJ, CF, CG, CI, CM, GA, GN, GQ, GW, ML, MR, NE, SN, TD, TG)
Publication Language: English (EN)
Filing Language: English (EN)
Also published as:
MXMX/a/2008/000885KR1020080018957IL188475EP1910359BRPI0613604-4JP2009501758
CN101243081CA2614443AU2006271809IN656/DELNP/2008