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Machine translation
1. (WO2007009906) INDOL-3-YL-CARBONYL-PIPERIDIN-BENZOIMIDAZOL DERIVATIVES AS V1A RECEPTOR ANTAGONISTS
Latest bibliographic data on file with the International Bureau   

Pub. No.:    WO/2007/009906    International Application No.:    PCT/EP2006/064075
Publication Date: 25.01.2007 International Filing Date: 11.07.2006
IPC:
C07D 403/12 (2006.01), C07D 413/14 (2006.01), A61K 31/422 (2006.01), A61P 25/24 (2006.01)
Applicants: F. HOFFMANN-LA ROCHE AG [CH/CH]; Grenzacherstrasse 124, CH-4070 Basel (CH) (For All Designated States Except US).
BISSANTZ, Caterina [DE/FR]; (FR) (For US Only).
GRUNDSCHOBER, Christophe [CH/CH]; (CH) (For US Only).
RATNI, Hasane [FR/FR]; (FR) (For US Only).
ROGERS-EVANS, Mark [GB/CH]; (CH) (For US Only).
SCHNIDER, Patrick [CH/CH]; (CH) (For US Only)
Inventors: BISSANTZ, Caterina; (FR).
GRUNDSCHOBER, Christophe; (CH).
RATNI, Hasane; (FR).
ROGERS-EVANS, Mark; (CH).
SCHNIDER, Patrick; (CH)
Agent: WASNER, Marita; Grenzacherstrasse 124, CH-4070 Basel (CH)
Priority Data:
05106695.9 21.07.2005 EP
05110506.2 09.11.2005 EP
Title (EN) INDOL-3-YL-CARBONYL-PIPERIDIN-BENZOIMIDAZOL DERIVATIVES AS V1A RECEPTOR ANTAGONISTS
(FR) DERIVES D'INDOL-3-YL-CARBONYL-PIPERIDIN-BENZOIMIDAZOL TENANT LIEU D'ANTAGONISTES DU RECEPTEUR V1A
Abstract: front page image
(EN)The present invention relates to Indol-3-yl-carbonyl-piperidin-benzoimidazol derivatives which act as Via receptor antagonists and which are represented by Formuly (I), wherein the residues R1 to R7 are as defined herein. The invention further relates to pharmaceutical compositions containing such compounds, their use in medicaments against dysmenorrhea, hypertension, chronic heart failure, inappropriate secretion of vasopressin, liver cirrhosis, nephritic syndrome, obsessive compulsive disorder, anxious and depressive disorders, and methods of preparation thereof.
(FR)L'invention concerne des dérivés d'indol-3-yl-carbonyl-pipéridin-benzoimidazol tenant lieu d'agonistes du récepteur Via et représentés par la formule (I), dans laquelle les restes R1 à R7 sont tels que définis dans la description. L'invention concerne aussi des compositions pharmaceutiques contenant les composés, leur utilisation dans des médicaments traitant la dysménorrhée, l'hypertension, l'insuffisance cardiaque chronique, la sécrétion inadéquate de vasopressine, la cirrhose hépatite, le syndrome néphrétique, le trouble compulsif obsessif, les troubles anxieux et dépressifs et leurs procédés de préparation.
Designated States: AE, AG, AL, AM, AT, AU, AZ, BA, BB, BG, BR, BW, BY, BZ, CA, CH, CN, CO, CR, CU, CZ, DE, DK, DM, DZ, EC, EE, EG, ES, FI, GB, GD, GE, GH, GM, HN, HR, HU, ID, IL, IN, IS, JP, KE, KG, KM, KN, KP, KR, KZ, LA, LC, LK, LR, LS, LT, LU, LV, LY, MA, MD, MG, MK, MN, MW, MX, MZ, NA, NG, NI, NO, NZ, OM, PG, PH, PL, PT, RO, RS, RU, SC, SD, SE, SG, SK, SL, SM, SY, TJ, TM, TN, TR, TT, TZ, UA, UG, US, UZ, VC, VN, ZA, ZM, ZW.
African Regional Intellectual Property Organization (BW, GH, GM, KE, LS, MW, MZ, NA, SD, SL, SZ, TZ, UG, ZM, ZW)
Eurasian Patent Organization (AM, AZ, BY, KG, KZ, MD, RU, TJ, TM)
European Patent Office (AT, BE, BG, CH, CY, CZ, DE, DK, EE, ES, FI, FR, GB, GR, HU, IE, IS, IT, LT, LU, LV, MC, NL, PL, PT, RO, SE, SI, SK, TR)
African Intellectual Property Organization (BF, BJ, CF, CG, CI, CM, GA, GN, GQ, GW, ML, MR, NE, SN, TD, TG).
Publication Language: English (EN)
Filing Language: English (EN)