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1. (WO2007009758) 2R,4S) -4- (4-ACETYL-3-HYDROXY-1-PIPERAZINYL) -N- { (1R) -1- [3, 5-BIS (TRIFLUOROMETHYL) PHENYL] ETHYL} -2- (4-FLUORO-2-METHYLPHENYL) -N-METHYL-1-PIPERIDINE-CARBOXAMIDE AS TACHYKININ RECEPTOR ANTAGONIST
Latest bibliographic data on file with the International Bureau

Pub. No.: WO/2007/009758 International Application No.: PCT/EP2006/007080
Publication Date: 25.01.2007 International Filing Date: 14.07.2006
IPC:
C07D 401/04 (2006.01) ,A61K 31/497 (2006.01) ,A61P 25/24 (2006.01) ,A61P 25/22 (2006.01) ,A61P 25/20 (2006.01) ,A61P 1/08 (2006.01) ,A61P 13/10 (2006.01)
C CHEMISTRY; METALLURGY
07
ORGANIC CHEMISTRY
D
HETEROCYCLIC COMPOUNDS
401
Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
02
containing two hetero rings
04
directly linked by a ring-member-to-ring- member bond
A HUMAN NECESSITIES
61
MEDICAL OR VETERINARY SCIENCE; HYGIENE
K
PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
31
Medicinal preparations containing organic active ingredients
33
Heterocyclic compounds
395
having nitrogen as a ring hetero atom, e.g. guanethidine, rifamycins
495
having six-membered rings with two nitrogen atoms as the only ring hetero atoms, e.g. piperazine
4965
Non-condensed pyrazines
497
containing further heterocyclic rings
A HUMAN NECESSITIES
61
MEDICAL OR VETERINARY SCIENCE; HYGIENE
P
SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
25
Drugs for disorders of the nervous system
24
Antidepressants
A HUMAN NECESSITIES
61
MEDICAL OR VETERINARY SCIENCE; HYGIENE
P
SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
25
Drugs for disorders of the nervous system
22
Anxiolytics
A HUMAN NECESSITIES
61
MEDICAL OR VETERINARY SCIENCE; HYGIENE
P
SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
25
Drugs for disorders of the nervous system
20
Hypnotics; Sedatives
A HUMAN NECESSITIES
61
MEDICAL OR VETERINARY SCIENCE; HYGIENE
P
SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
1
Drugs for disorders of the alimentary tract or the digestive system
08
for nausea, cinetosis or vertigo; Antiemetics
A HUMAN NECESSITIES
61
MEDICAL OR VETERINARY SCIENCE; HYGIENE
P
SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
13
Drugs for disorders of the urinary system
10
of the bladder
Applicants:
GLAXO GROUP LIMITED [GB/GB]; Glaxo Wellcome House Berkeley Avenue Greenford Middlesex UB6 0NN, GB (AllExceptUS)
MARTINUCCI, Silvia [IT/IT]; IT (UsOnly)
ROBERTS, Andrew [GB/GB]; GB (UsOnly)
Inventors:
MARTINUCCI, Silvia; IT
ROBERTS, Andrew; GB
Agent:
FILLER, Wendy Anne; GlaxoSmithKline Corporate Intellectual Property Cn925.1 980 Great West Road Brentford Middlesex TW8 9GS, GB
Priority Data:
0514705.318.07.2005GB
Title (EN) 2R,4S) -4- (4-ACETYL-3-HYDROXY-1-PIPERAZINYL) -N- { (1R) -1- [3, 5-BIS (TRIFLUOROMETHYL) PHENYL] ETHYL} -2- (4-FLUORO-2-METHYLPHENYL) -N-METHYL-1-PIPERIDINE-CARBOXAMIDE AS TACHYKININ RECEPTOR ANTAGONIST
(FR) COMPOSES CHIMIQUES
Abstract:
(EN) The present invention relates to a compound of formula (I) or a pharmaceutically acceptable salt or solvate thereof, process for their preparation, their use in the treatment of conditions mediated by tachykinins and pharmaceutical compositions containing them.
(FR) L'invention concerne un composé représenté par la formule (I) ou un sel ou un solvate pharmaceutiquement acceptables de ce composé, un procédé permettant de préparer ces composés, l'utilisation de ces composés pour le traitement de maladies dont les tachykinines sont des médiateurs, et des compositions pharmaceutiques contenant ces composés.
front page image
Designated States: AE, AG, AL, AM, AT, AU, AZ, BA, BB, BG, BR, BW, BY, BZ, CA, CH, CN, CO, CR, CU, CZ, DE, DK, DM, DZ, EC, EE, EG, ES, FI, GB, GD, GE, GH, GM, HN, HR, HU, ID, IL, IN, IS, JP, KE, KG, KM, KN, KP, KR, KZ, LA, LC, LK, LR, LS, LT, LU, LV, LY, MA, MD, MG, MK, MN, MW, MX, MZ, NA, NG, NI, NO, NZ, OM, PG, PH, PL, PT, RO, RS, RU, SC, SD, SE, SG, SK, SL, SM, SY, TJ, TM, TN, TR, TT, TZ, UA, UG, US, UZ, VC, VN, ZA, ZM, ZW
African Regional Intellectual Property Organization (ARIPO) (BW, GH, GM, KE, LS, MW, MZ, NA, SD, SL, SZ, TZ, UG, ZM, ZW)
Eurasian Patent Organization (AM, AZ, BY, KG, KZ, MD, RU, TJ, TM)
European Patent Office (AT, BE, BG, CH, CY, CZ, DE, DK, EE, ES, FI, FR, GB, GR, HU, IE, IS, IT, LT, LU, LV, MC, NL, PL, PT, RO, SE, SI, SK, TR)
African Intellectual Property Organization (BF, BJ, CF, CG, CI, CM, GA, GN, GQ, GW, ML, MR, NE, SN, TD, TG)
Publication Language: English (EN)
Filing Language: English (EN)