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1. (WO2007009710) SUBSTITUTED PYRAZOLINE COMPOUNDS: METHODS FOR THEIR PREPARATION
Latest bibliographic data on file with the International Bureau   

Pub. No.:    WO/2007/009710    International Application No.:    PCT/EP2006/006984
Publication Date: 25.01.2007 International Filing Date: 16.07.2006
IPC:
C07D 231/06 (2006.01)
Applicants: LABORATORIOS DEL DR. ESTEVE, S.A. [ES/ES]; Avenida Mare de Deu de Montserrat 221, E-08041 Barcelona (ES) (For All Designated States Except US).
TORRENS JOVER, Antonio [ES/ES]; (ES) (For US Only).
YENES MINGUEZ, Susana [ES/ES]; (ES) (For US Only)
Inventors: TORRENS JOVER, Antonio; (ES).
YENES MINGUEZ, Susana; (ES)
Agent: PETERS, Hajo; Bosch, Graf von Stosch, Jehle Patentanwaltsgesellschaft mbH, Flüggenstrasse 13, 80639 München (DE)
Priority Data:
05384007.0 15.07.2005 EP
60/705,474 05.08.2005 US
Title (EN) SUBSTITUTED PYRAZOLINE COMPOUNDS: METHODS FOR THEIR PREPARATION
(FR) COMPOSES A BASE DE PYRAZOLINE SUBSTITUES, LEURS PROCEDES DE PREPARATION
Abstract: front page image
(EN)Methods for obtaining the substituted pyrazoline compounds of general formula (Ia) as well as the intermediates of general formula (III) to this compound. Thus 5-(R10,R11,R12-phenyl)-1-(R13,R14,R15-phenyl)-N-(piperidin-1-yl)-4,5-dihydro-1H- pyrazole-3-carboxamide (II) can be obtained by the reaction of an activated carbonyl compound derived from 5-(R10,R11,R12-phenyl)-1-(R13,R14,R15-phenyl)-4,5-dihydro- 1H-pyrazole-3-carboxylic acid (IIIa) with N-aminopiperidine in the presence or absence of an acid acceptor or suitable condensing agent.
(FR)La présente invention a trait à des procédés pour l'obtention de composés à base de pyrazoline substitués de formule générale (Ia), ainsi qu'à des intermédiaires de formule générale (III) à ce composé. Ainsi, le 5- (R10,R11,R12-phényl)-1-(R13,R14,R15-phényl)-N-(pipéridin-1-yl)-4,5-dihydro-1H- pyrazole-3-carboxamide (II) peut être obtenu par la réaction d'un composé carbonyle activé dérivé de l'acide 5-(R10,R11,R12-phényl)-1-(R13,R14,R15-phényl)-4,5-dihydro- 1H-pyrazole-3-carboxylique (IIIa) avec N-aminopipéridine en présence ou en l'absence d'un accepteur d'acide ou d'un agent de condensation approprié.
Designated States: AE, AG, AL, AM, AT, AU, AZ, BA, BB, BG, BR, BW, BY, BZ, CA, CH, CN, CO, CR, CU, CZ, DE, DK, DM, DZ, EC, EE, EG, ES, FI, GB, GD, GE, GH, GM, HN, HR, HU, ID, IL, IN, IS, JP, KE, KG, KM, KN, KP, KR, KZ, LA, LC, LK, LR, LS, LT, LU, LV, LY, MA, MD, MG, MK, MN, MW, MX, MZ, NA, NG, NI, NO, NZ, OM, PG, PH, PL, PT, RO, RS, RU, SC, SD, SE, SG, SK, SL, SM, SY, TJ, TM, TN, TR, TT, TZ, UA, UG, US, UZ, VC, VN, ZA, ZM, ZW.
African Regional Intellectual Property Organization (BW, GH, GM, KE, LS, MW, MZ, NA, SD, SL, SZ, TZ, UG, ZM, ZW)
Eurasian Patent Organization (AM, AZ, BY, KG, KZ, MD, RU, TJ, TM)
European Patent Office (AT, BE, BG, CH, CY, CZ, DE, DK, EE, ES, FI, FR, GB, GR, HU, IE, IS, IT, LT, LU, LV, MC, NL, PL, PT, RO, SE, SI, SK, TR)
African Intellectual Property Organization (BF, BJ, CF, CG, CI, CM, GA, GN, GQ, GW, ML, MR, NE, SN, TD, TG).
Publication Language: English (EN)
Filing Language: English (EN)