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1. (WO2007009403) GROWTH-STIMULATING POLYPEPTIDES FOR USE IN FISH AND CRUSTACEANS
Latest bibliographic data on file with the International Bureau

Pub. No.: WO/2007/009403 International Application No.: PCT/CU2006/000006
Publication Date: 25.01.2007 International Filing Date: 23.06.2006
Chapter 2 Demand Filed: 02.11.2006
IPC:
C07K 14/46 (2006.01) ,C07K 14/61 (2006.01) ,C12P 21/02 (2006.01) ,A23K 1/165 (2006.01)
C CHEMISTRY; METALLURGY
07
ORGANIC CHEMISTRY
K
PEPTIDES
14
Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
435
from animals; from humans
46
from vertebrates
C CHEMISTRY; METALLURGY
07
ORGANIC CHEMISTRY
K
PEPTIDES
14
Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
435
from animals; from humans
575
Hormones
61
Growth hormone (GH) (Somatotropin)
C CHEMISTRY; METALLURGY
12
BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
P
FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
21
Preparation of peptides or proteins
02
having a known sequence of two or more amino acids, e.g. glutathione
A HUMAN NECESSITIES
23
FOODS OR FOODSTUFFS; THEIR TREATMENT, NOT COVERED BY OTHER CLASSES
K
FEEDING-STUFFS SPECIALLY ADAPTED FOR ANIMALS; METHODS SPECIALLY ADAPTED FOR PRODUCTION THEREOF
1
Animal feeding-stuffs
16
supplemented with accessory food factors; Salt blocks
165
with steroids, hormones, or enzymes
Applicants:
CENTRO DE INGENIERIA GENETICA Y BIOTECNOLOGIA [CU/CU]; Ave. 31 Entre 158 Y 190, Cubanacán Playa Ciudad De La Habana 10600, CU (AllExceptUS)
ACOSTA ALBA, Jannel [CU/CU]; CU (UsOnly)
ESTRADA GARCÍA, Mario, Pablo [CU/CU]; CU (UsOnly)
CARPIO GONZÁLEZ, Yamila [CU/CU]; CU (UsOnly)
MORALES FERNÁNDEZ, Reynold [CU/CU]; CU (UsOnly)
Inventors:
ACOSTA ALBA, Jannel; CU
ESTRADA GARCÍA, Mario, Pablo; CU
CARPIO GONZÁLEZ, Yamila; CU
MORALES FERNÁNDEZ, Reynold; CU
Agent:
VAZQUEZ CASTILLO, Mariela; Departamento de Patentes Ave. 31 Entre 158 Y 190, Cubanacán Playa Ciudad De La Habana 10600, CU
Priority Data:
2005-013521.07.2005CU
Title (EN) GROWTH-STIMULATING POLYPEPTIDES FOR USE IN FISH AND CRUSTACEANS
(ES) POLIPÉPTIDOS ESTIMULADORES DEL CRECIMIENTO PARA USO EN PECES Y CRUSTÁCEOS
(FR) POLYPEPTIDES STIMULATEURS DE CROISSANCE DESTINES A ETRE UTILISES CHEZ LES POISSONS ET LES CRUSTACES
Abstract:
(EN) The invention relates to polypeptides which demonstrate an activity greater than tilapia growth hormone. The aforementioned polypeptides can stimulate the growth, survival and quality of fish and crustacean larvae. In addition, the polypeptides increase the defence of the organism against pathogenic agents and stimulate parameters relating to the immune system of aquatic organisms. The genes that code for said polypeptides were cloned in a Pichia pastoris expression vector which can be used to obtain extracellular protein. The culture supernatant containing the polypeptides in question was administered to aquatic organisms using immersion baths or as a feed supplement.
(ES) La presente invención está relacionada con polipéptidos que muestran una actividad superior a la hormona de crecimiento de tilapia. Estos polipéptidos son capaces de estimular el crecimiento, la sobrevida y calidad de las larvas de peces y crustáceos. Además, incrementan la defensa del organismo contra agentes patógenos y estimulan parámetros relacionados con el sistema inmune de organismos acuáticos. Los genes que codifican para dichos polipéptidos fueron clonados en un vector de expresión en Pichia pastoris que permite la obtención de la proteína de forma extracelular. El sobrenadante de cultivo que contiene los polipéptidos de interés fue administrado por baños de inmersión o como suplemento en el pienso a organismos acuáticos.
(FR) La présente invention concerne des polypeptides qui montrent une activité supérieure à celle de l'hormone de croissance de tilapia. Ces polypeptides sont capables de stimuler la croissance, la survie et la qualité des larves de poissons et de crustacés. De plus, ils augmentent la défense de l'organisme contre les agents pathogènes et ils stimulent les paramètres relatifs au système immun d'organismes aquatiques. Les gènes qui codent lesdits polypeptides ont été clonés dans un vecteur d'expression de Pichia pastoris qui permet l'obtention de la protéine de manière extracellulaire. Le surnageant de culture qui contient les polypeptides d'intérêt a été administré par bains d'immersion ou sous la forme d'un supplément dans l'aliment à des organismes aquatiques.
Designated States: AE, AG, AL, AM, AT, AU, AZ, BA, BB, BG, BR, BW, BY, BZ, CA, CH, CN, CO, CR, CU, CZ, DE, DK, DM, DZ, EC, EE, EG, ES, FI, GB, GD, GE, GH, GM, HN, HR, HU, ID, IL, IN, IS, JP, KE, KG, KM, KN, KP, KR, KZ, LA, LC, LK, LR, LS, LT, LU, LV, LY, MA, MD, MG, MK, MN, MW, MX, MZ, NA, NG, NI, NO, NZ, OM, PG, PH, PL, PT, RO, RS, RU, SC, SD, SE, SG, SK, SL, SM, SY, TJ, TM, TN, TR, TT, TZ, UA, UG, US, UZ, VC, VN, ZA, ZM, ZW
African Regional Intellectual Property Organization (ARIPO) (BW, GH, GM, KE, LS, MW, MZ, NA, SD, SL, SZ, TZ, UG, ZM, ZW)
Eurasian Patent Organization (AM, AZ, BY, KG, KZ, MD, RU, TJ, TM)
European Patent Office (AT, BE, BG, CH, CY, CZ, DE, DK, EE, ES, FI, FR, GB, GR, HU, IE, IS, IT, LT, LU, LV, MC, NL, PL, PT, RO, SE, SI, SK, TR)
African Intellectual Property Organization (BF, BJ, CF, CG, CI, CM, GA, GN, GQ, GW, ML, MR, NE, SN, TD, TG)
Publication Language: Spanish (ES)
Filing Language: Spanish (ES)
Also published as:
MXMX/a/2008/000962KR1020080041656IL188864EP1911764ZA2008/00924JP2009501735
US20100167998BRPI0613621CN101253194CA2615833AU2006272216MYPI 20063173
TH86430IN1098/DELNP/2008