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1. (WO2007009388) WATER-SOLUBLE ARTEMISININ DERIVATIVES, THEIR PREPARATION METHODS, THE PHARMACEUTICAL COMPOSITIONS AND THE USE THEREOF
Latest bibliographic data on file with the International Bureau   

Pub. No.:    WO/2007/009388    International Application No.:    PCT/CN2006/001782
Publication Date: 25.01.2007 International Filing Date: 20.07.2006
Chapter 2 Demand Filed:    25.02.2007    
IPC:
C07D 493/18 (2006.01), A61K 31/357 (2006.01), C07D 323/00 (2006.01), C07D 321/00 (2006.01), C07D 311/00 (2006.01), A61P 37/06 (2006.01)
Applicants: SHANGHAI INSTITUTE OF MATERIA MEDICA, CHINESE ACADEMY OF SCIENCES [CN/CN]; 555 Zu Chong Zhi Road Pudong New District Shanghai 201203 (CN) (For All Designated States Except US).
LI, Ying [CN/CN]; (CN) (For US Only).
ZUO, Jianping [CN/CN]; (CN) (For US Only).
YANG, Zhong Shun [CN/CN]; (CN) (For US Only).
WANG, Junxia [CN/CN]; (CN) (For US Only).
ZHANG, Yu [CN/CN]; (CN) (For US Only).
TANG, Wei [CN/CN]; (CN) (For US Only).
ZHANG, Jianxin [CN/CN]; (CN) (For US Only)
Inventors: LI, Ying; (CN).
ZUO, Jianping; (CN).
YANG, Zhong Shun; (CN).
WANG, Junxia; (CN).
ZHANG, Yu; (CN).
TANG, Wei; (CN).
ZHANG, Jianxin; (CN)
Agent: SHANGHAI KAIJI INTELLECTUAL PROPERTY AGENT CO., LTD.; Rm. 1501, 188 Nandandong Road Shanghai 200030 (CN)
Priority Data:
200510028056.9 22.07.2005 CN
Title (EN) WATER-SOLUBLE ARTEMISININ DERIVATIVES, THEIR PREPARATION METHODS, THE PHARMACEUTICAL COMPOSITIONS AND THE USE THEREOF
(FR) DERIVES D'ARTEMISININE HYDROSOLUBLES, LEURS PROCEDES DE PREPARATION, LEURS COMPOSITIONS PHARMACEUTIQUES ET LEUR UTILISATION
(ZH) 水溶性青蒿素衍生物﹑制法﹑药物组合及用途
Abstract: front page image
(EN)Water-soluble artemisinin derivatives, their preparation methods, the pharmaceutical compositions containing them and the use thereof are disclosed. The artemisinin derivatives have the structure as following(formula I): These compounds and compositions have immuno-suppressive activities which has been proved by pharmacological test, and may be used to prepare novel immuno-suppressants for treating the diseases caused by hypofunction of human immunity( e. g. auto-immune diseases such as lupus erythematosus, rheumatoid arthritis, multiple sclerosis and the like), and may be useful as anti-rejection agents in organ transplantation.
(FR)La présente invention a trait à des dérivés d'artémisinine hydrosolubles, leurs procédés de préparation, les compositions pharmaceutiques en contenant et leur utilisation. Les dérivés d'artémisinine sont représentés par la formule (I). Ces composés et compositions présentent des activités immunosuppressives qui ont été prouvées par test pharmacologique, et peuvent être utilisés pour la préparation de nouveaux immunosuppresseurs pour le traitement de maladies provoquées par un hypofonctionnement de l'immunité humaine (par exemple, des maladies auto-immunes telles que le lupus érythémateux, la polyarthrite rhumatoïde, la sclérose en plaques et analogues), et peuvent être utiles en tant qu'agents d'anti-rejet dans la transplantation d'organes.
Designated States: AE, AG, AL, AM, AT, AU, AZ, BA, BB, BG, BR, BW, BY, BZ, CA, CH, CN, CO, CR, CU, CZ, DE, DK, DM, DZ, EC, EE, EG, ES, FI, GB, GD, GE, GH, GM, HN, HR, HU, ID, IL, IN, IS, JP, KE, KG, KM, KN, KP, KR, KZ, LA, LC, LK, LR, LS, LT, LU, LV, LY, MA, MD, MG, MK, MN, MW, MX, MZ, NA, NG, NI, NO, NZ, OM, PG, PH, PL, PT, RO, RS, RU, SC, SD, SE, SG, SK, SL, SM, SY, TJ, TM, TN, TR, TT, TZ, UA, UG, US, UZ, VC, VN, ZA, ZM, ZW.
African Regional Intellectual Property Organization (BW, GH, GM, KE, LS, MW, MZ, NA, SD, SL, SZ, TZ, UG, ZM, ZW)
Eurasian Patent Organization (AM, AZ, BY, KG, KZ, MD, RU, TJ, TM)
European Patent Office (AT, BE, BG, CH, CY, CZ, DE, DK, EE, ES, FI, FR, GB, GR, HU, IE, IS, IT, LT, LU, LV, MC, NL, PL, PT, RO, SE, SI, SK, TR)
African Intellectual Property Organization (BF, BJ, CF, CG, CI, CM, GA, GN, GQ, GW, ML, MR, NE, SN, TD, TG).
Publication Language: Chinese (ZH)
Filing Language: Chinese (ZH)