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1. (WO2007009355) PACLITAXEL INJECTION AND PREPARATION METHOD THEREOF
Latest bibliographic data on file with the International Bureau   

Pub. No.:    WO/2007/009355    International Application No.:    PCT/CN2006/001665
Publication Date: 25.01.2007 International Filing Date: 13.07.2006
Chapter 2 Demand Filed:    21.11.2006    
IPC:
A61K 9/08 (2006.01), A61K 31/337 (2006.01), A61P 35/00 (2006.01)
Applicants: HOLLEY PHARMACEUTICALS CO. LTD. [CN/CN]; 12th Floor, Guangyu Building No.76, North Jianxin Road Jiangbei District Chongqing 400020 (CN) (For All Designated States Except US).
CHEN, Jianming [CN/CN]; (CN) (For US Only).
GAO, Baoan [CN/CN]; (CN) (For US Only).
HUANG, Zundong [CN/CN]; (CN) (For US Only).
CHEN, Haisheng [CN/CN]; (CN) (For US Only).
XIAO, Qin [CN/CN]; (CN) (For US Only).
HUANG, Chengan [CN/CN]; (CN) (For US Only)
Inventors: CHEN, Jianming; (CN).
GAO, Baoan; (CN).
HUANG, Zundong; (CN).
CHEN, Haisheng; (CN).
XIAO, Qin; (CN).
HUANG, Chengan; (CN)
Agent: CHINA SINDA INTELLECTUAL PROPERTY LTD.; B11th Floor, Focus Place 19 Financial Street Beijing 100032 (CN)
Priority Data:
200510027913.3 20.07.2005 CN
Title (EN) PACLITAXEL INJECTION AND PREPARATION METHOD THEREOF
(FR) INJECTION DE PACLITAXEL ET SA MÉTHODE DE PRÉPARATION
(ZH) 一种紫杉醇注射剂及其制备方法
Abstract: front page image
(EN)A paclitaxel injection and the preparation method thereof. The said paclitaxel injection consists of paclitaxel 0.01-2%(w/v), stabilizer 1-70%(w/v), and the remainder is solvent for injection, wherein stabilizer is one or more agents selected from soybean phospholipid, yolk phospholipid, Tween-80, cholesterol, sodium cholate, Poloxamer 188, monoolein. It is prepared as follows: dissolving the stabilizer in said solvent by thermal stirring or ultrasonic stirring, adding paclitaxel, stirring, filtering, loading it in containers and sterilizing. It has low toxic by-effect and stable property.
(FR)L’invention concerne une injection de paclitaxel et sa méthode de préparation. Ladite injection de paclitaxel consiste en du paclitaxel 0,01-2 % (p/v) et du stabilisateur 1-70%(p/v), le reste étant du solvant pour injection, le stabilisateur étant un ou plusieurs agents sélectionnés à partir du phospholipide de graine de soja, du phospholipide de jaune d'oeuf, de Tween-80, du cholestérol, du cholate de sodium, de Poloxamer 188 et de la monooléine. Elle se prépare comme suit : dissoudre le stabilisateur dans ledit solvant par agitation thermique ou ultrasonique, ajouter le paclitaxel, agiter, filtrer, charger dans des contenants et stériliser. Elle a un faible effet secondaire toxique et est stable.
Designated States: AE, AG, AL, AM, AT, AU, AZ, BA, BB, BG, BR, BW, BY, BZ, CA, CH, CN, CO, CR, CU, CZ, DE, DK, DM, DZ, EC, EE, EG, ES, FI, GB, GD, GE, GH, GM, HN, HR, HU, ID, IL, IN, IS, JP, KE, KG, KM, KN, KP, KR, KZ, LA, LC, LK, LR, LS, LT, LU, LV, LY, MA, MD, MG, MK, MN, MW, MX, MZ, NA, NG, NI, NO, NZ, OM, PG, PH, PL, PT, RO, RS, RU, SC, SD, SE, SG, SK, SL, SM, SY, TJ, TM, TN, TR, TT, TZ, UA, UG, US, UZ, VC, VN, ZA, ZM, ZW.
African Regional Intellectual Property Organization (BW, GH, GM, KE, LS, MW, MZ, NA, SD, SL, SZ, TZ, UG, ZM, ZW)
Eurasian Patent Organization (AM, AZ, BY, KG, KZ, MD, RU, TJ, TM)
European Patent Office (AT, BE, BG, CH, CY, CZ, DE, DK, EE, ES, FI, FR, GB, GR, HU, IE, IS, IT, LT, LU, LV, MC, NL, PL, PT, RO, SE, SI, SK, TR)
African Intellectual Property Organization (BF, BJ, CF, CG, CI, CM, GA, GN, GQ, GW, ML, MR, NE, SN, TD, TG).
Publication Language: Chinese (ZH)
Filing Language: Chinese (ZH)