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1. (WO2007009299) OPTICALLY PURE N',N'-DI SUBSTITUTED -PROLYLHYDRAZINES AS WELL AS THE PREPARATION AND USE THEREOF
Latest bibliographic data on file with the International Bureau

Pub. No.: WO/2007/009299 International Application No.: PCT/CN2005/001134
Publication Date: 25.01.2007 International Filing Date: 27.07.2005
IPC:
C07D 295/02 (2006.01) ,C07C 243/12 (2006.01)
C CHEMISTRY; METALLURGY
07
ORGANIC CHEMISTRY
D
HETEROCYCLIC COMPOUNDS
295
Heterocyclic compounds containing polymethylene-imine rings with at least five ring members, 3-azabicyclo [3.2.2] nonane, piperazine, morpholine or thiomorpholine rings, having only hydrogen atoms directly attached to the ring carbon atoms
02
containing only hydrogen and carbon atoms in addition to the ring hetero elements
C CHEMISTRY; METALLURGY
07
ORGANIC CHEMISTRY
C
ACYCLIC OR CARBOCYCLIC COMPOUNDS
243
Compounds containing chains of nitrogen atoms singly-bound to each other, e.g. hydrazines, triazanes
10
Hydrazines
12
having nitrogen atoms of hydrazine groups bound to acyclic carbon atoms
Applicants:
中国科学院成都生物研究所 CHENGDU INSTITUTE OF BIOLOGY, CHINESE ACADEMY OF SCIENCES [CN/CN]; 中国四川省成都市人民南路四段九号, Sichuan 610041 Renmin South Road 4-9 610041 Chengdu City, Sichuan Province, CN (AllExceptUS)
孙健 SUN, Jian [CN/CN]; CN (UsOnly)
程传玲 CHENG, Chuan ling [CN/CN]; CN (UsOnly)
Inventors:
孙健 SUN, Jian; CN
程传玲 CHENG, Chuan ling; CN
Agent:
北京信慧永光知识产权代理有限责任公司 BEIJING SUNHOPE INTELLECTUAL PROPERTY LIMITED; 中国北京市海淀区知春路9号坤讯大厦1106室武玉琴, Beijing 100083 Yuqin WU Room 1106, Kunxun Plaza, Zhichun Road 9, Haidian District 100083 Beijing, CN
Priority Data:
200510084330.419.07.2005CN
Title (EN) OPTICALLY PURE N',N'-DI SUBSTITUTED -PROLYLHYDRAZINES AS WELL AS THE PREPARATION AND USE THEREOF
(FR) PROLYLHYDRAZINES N',N'-DISUBSTITUEES OPTIQUEMENT PURES, LEUR PREPARATION ET LEUR UTILISATION
(ZH) 光学纯N',N'- 二取代脯氨酰肼化合物及其制备方法和应用
Abstract:
(EN) A optically pure N',N'-disubstituted-prolylhydrazines with D- or L- configurations or their Bronstedt salts as well as the preparation and use thereof, and the formula structure of it as followings or wherein: R1 and R2 are alkyl, substituted alkyl, heteroatom-containing alkyl, alkyl having heteroatom­containing substituents, acyl and hydrogen, respectively, or Ri and R2 forma 3- to 10- membered ring. The compounds catalyze stereoselectively aldol reaction, Michael addition reacton, Mannich reaction, alpha-amination reaction, alpha-amine oxidation reaction, alpha-alkylation reaction, alpha­chloridization, alpha-thioreaction, or Baylis-Hillman reaction alone or with acids.
(FR) L'invention concerne des prolylhydrazines N',N'-disubstituées optiquement pures, de configuration D ou L, ou leurs sels de Bronstedt, ainsi que leur préparation et leur utilisation ; lesdites prolylhydrazines étant représentées par la formule suivante : où R1 et R2 sont respectivement un groupe alkyle, un groupe alkyle substitué, un groupe alkyle contenant des hétéroatomes, un groupe alkyle ayant des substituants contenant des hétéroatomes, un groupe acyle ou un atome d’hydrogène, ou R1 et R2 forment un cycle comportant de 3 à 10 éléments. Ces composés sont utiles en tant que catalyseurs stéréosélectifs pour la réaction aldol, la réaction d'addition de Michael, la réaction de Mannich, la réaction d'alpha-amination, la réaction d'oxydation d'alpha-amines, la réaction d'alpha-alkylation, la réaction d'alpha-chlorage, l'alpha-thioréaction, ou la réaction de Baylis-Hillman seule ou en présence d'acides.
(ZH) 本发明公开了一种光学纯N',N'-二取代脯氨酰肼化合物或其布朗斯特酸盐及其制备方法和应用,结构式如下:构型为L或D,其中:R1和R2分别为烃基、取代的烃基、含杂原子的烃基、取代基含杂原子的烃基、酰基和氢,R1与R2成3-10元环。本发明的化合物单独或者与酸共同作用,立体选择性催化羟醛反应、迈克尔加成反应、曼尼希反应、α-胺基化反应、α-胺氧化反应、α-烷基化反应、α-氯代反应、α-硫代反应或拜里斯-赫尔曼反应。
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Designated States: AE, AG, AL, AM, AT, AU, AZ, BA, BB, BG, BR, BW, BY, BZ, CA, CH, CN, CO, CR, CU, CZ, DE, DK, DM, DZ, EC, EE, EG, ES, FI, GB, GD, GE, GH, GM, HR, HU, ID, IL, IN, IS, JP, KE, KG, KM, KP, KR, KZ, LC, LK, LR, LS, LT, LU, LV, MA, MD, MG, MK, MN, MW, MX, MZ, NA, NG, NI, NO, NZ, OM, PG, PH, PL, PT, RO, RU, SC, SD, SE, SG, SK, SL, SM, SY, TJ, TM, TN, TR, TT, TZ, UA, UG, US, UZ, VC, VN, YU, ZA, ZM, ZW
African Regional Intellectual Property Organization (ARIPO) (BW, GH, GM, KE, LS, MW, MZ, NA, SD, SL, SZ, TZ, UG, ZM, ZW)
Eurasian Patent Organization (AM, AZ, BY, KG, KZ, MD, RU, TJ, TM)
European Patent Office (AT, BE, BG, CH, CY, CZ, DE, DK, EE, ES, FI, FR, GB, GR, HU, IE, IS, IT, LT, LU, LV, MC, NL, PL, PT, RO, SE, SI, SK, TR)
African Intellectual Property Organization (BF, BJ, CF, CG, CI, CM, GA, GN, GQ, GW, ML, MR, NE, SN, TD, TG)
Publication Language: Chinese (ZH)
Filing Language: Chinese (ZH)