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1. (WO2007009265) NOVEL &bgr;-CYCLODEXTRIN-BASED MOLECULES AND DRUG DELIVERY COMPOSITIONS
Latest bibliographic data on file with the International Bureau

Pub. No.: WO/2007/009265 International Application No.: PCT/CA2006/001219
Publication Date: 25.01.2007 International Filing Date: 24.07.2006
IPC:
C08B 37/16 (2006.01) ,A61K 47/40 (2006.01) ,A61K 31/70 (2006.01) ,A61K 31/7052 (2006.01) ,A61K 31/724 (2006.01) ,A61K 38/00 (2006.01)
C CHEMISTRY; METALLURGY
08
ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
B
POLYSACCHARIDES; DERIVATIVES THEREOF
37
Preparation of polysaccharides not provided for in groups C08B1/-C08B35/110; Derivatives thereof
16
Cyclodextrin; Derivatives thereof
A HUMAN NECESSITIES
61
MEDICAL OR VETERINARY SCIENCE; HYGIENE
K
PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
47
Medicinal preparations characterised by the non-active ingredients used, e.g. carriers, inert additives
30
Macromolecular compounds
36
Polysaccharides; Derivatives thereof
40
Cyclodextrins; Derivatives thereof
A HUMAN NECESSITIES
61
MEDICAL OR VETERINARY SCIENCE; HYGIENE
K
PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
31
Medicinal preparations containing organic active ingredients
70
Carbohydrates; Sugars; Derivatives thereof
A HUMAN NECESSITIES
61
MEDICAL OR VETERINARY SCIENCE; HYGIENE
K
PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
31
Medicinal preparations containing organic active ingredients
70
Carbohydrates; Sugars; Derivatives thereof
7042
Compounds having saccharide radicals and heterocyclic rings
7052
having nitrogen as a ring hetero atom, e.g. nucleosides, nucleotides
A HUMAN NECESSITIES
61
MEDICAL OR VETERINARY SCIENCE; HYGIENE
K
PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
31
Medicinal preparations containing organic active ingredients
70
Carbohydrates; Sugars; Derivatives thereof
715
Polysaccharides, i.e. having more than five saccharide radicals attached to each other by glycosidic linkages; Derivatives thereof, e.g. ethers, esters
716
Glucans
724
Cyclodextrins
A HUMAN NECESSITIES
61
MEDICAL OR VETERINARY SCIENCE; HYGIENE
K
PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
38
Medicinal preparations containing peptides
Applicants:
THE GOVERNORS OF THE UNIVERSITY OF ALBERTA TEC EDMONTON [CA/CA]; Suite 4000 8308 - 114 Street Research Transition Facility University of Alberta Edmonton, Alberta T6G 2E1, CA
Inventors:
WIEBE, Leonard; CA
DIAKUR, James; CA
Agent:
SHERBURNE, Craig, K.; #236, 6030 - 88th Street Edmonton, Alberta T6E 6G4, CA
Priority Data:
60/701,48922.07.2005CA
Title (EN) NOVEL &bgr;-CYCLODEXTRIN-BASED MOLECULES AND DRUG DELIVERY COMPOSITIONS
(FR) MOLECULES A BASE DE ß-CYCLODEXTRINE ET COMPOSITIONS DE DELIVRANCE DE MEDICAMENTS
Abstract:
(EN) The present invention provides for novel &bgr;-cyclodextrin-based molecules of formula (I), wherein X is a molecule of net positive or negative charge at physiologic conditions and Y is a molecule selected from the group consisting of carbohydrates and polypeptides. The molecules are useful for the delivery of compounds to a mammal, more particularly for the intracellular delivery of nucleotides, nucleotide analogues or compounds with a heterocyclic base. Also provided for are novel therapeutic complexes comprising the novel &bgr;-cyclodextrin-based molecules complexed with nucleotide analogues or heterogeneous or homogeneous oligomers comprised of nucleotide analogues.
(FR) Molécules à base de ß-cyclodextrine de formule (I), X étant une molécule de charge positive ou négative nette aux conditions physiologiques et Y une molécule qui peut appartenir aux hydrates de carbone et aux polypeptides. Les molécules en question sont utiles pour la délivrance de composés à un mammifère, plus précisément la délivrance intracellulaire de nucléotides, d'analogues de nucléotides ou de composés avec une base hétérocyclique. Egalement, complexes thérapeutiques renfermant les molécules décrites qui forment des complexes acvec des analogues de nucléotides ou des oligomères homogènes ou hétérogènes constitués d'analogues de nucléotides.
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Designated States: AE, AG, AL, AM, AT, AU, AZ, BA, BB, BG, BR, BW, BY, BZ, CA, CH, CN, CO, CR, CU, CZ, DE, DK, DM, DZ, EC, EE, EG, ES, FI, GB, GD, GE, GH, GM, HN, HR, HU, ID, IL, IN, IS, JP, KE, KG, KM, KN, KP, KR, KZ, LA, LC, LK, LR, LS, LT, LU, LV, LY, MA, MD, MG, MK, MN, MW, MX, MZ, NA, NG, NI, NO, NZ, OM, PG, PH, PL, PT, RO, RS, RU, SC, SD, SE, SG, SK, SL, SM, SY, TJ, TM, TN, TR, TT, TZ, UA, UG, US, UZ, VC, VN, ZA, ZM, ZW
African Regional Intellectual Property Organization (ARIPO) (BW, GH, GM, KE, LS, MW, MZ, NA, SD, SL, SZ, TZ, UG, ZM, ZW)
Eurasian Patent Organization (AM, AZ, BY, KG, KZ, MD, RU, TJ, TM)
European Patent Office (AT, BE, BG, CH, CY, CZ, DE, DK, EE, ES, FI, FR, GB, GR, HU, IE, IS, IT, LT, LU, LV, MC, NL, PL, PT, RO, SE, SI, SK, TR)
African Intellectual Property Organization (BF, BJ, CF, CG, CI, CM, GA, GN, GQ, GW, ML, MR, NE, SN, TD, TG)
Publication Language: English (EN)
Filing Language: English (EN)