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1. (WO2007009233) PEPTIDE-BASED CYTOKINE VACCINES IN THE TREATMENT OF AUTOIMMUNE AND INFLAMMATORY DISEASES
Latest bibliographic data on file with the International Bureau   

Pub. No.:    WO/2007/009233    International Application No.:    PCT/CA2006/001170
Publication Date: 25.01.2007 International Filing Date: 18.07.2006
IPC:
C12N 15/28 (2006.01), A61K 38/10 (2006.01), A61K 38/08 (2006.01), A61K 38/19 (2006.01), A61K 39/00 (2006.01), A61K 39/29 (2006.01), A61K 39/385 (2006.01), A61P 29/00 (2006.01), A61P 37/06 (2006.01), C07K 14/525 (2006.01)
Applicants: UNIVERSITY OF MANITOBA [CA/CA]; Industry Liaison Office, 631 Drake Centre, Winnipeg, Manitoba R3T 5V4 (CA) (For All Designated States Except US).
PENG, Zhikang [CN/CA]; (CA) (For US Only).
MA, Yanbing [CN/CA]; (CA) (For US Only)
Inventors: PENG, Zhikang; (CA).
MA, Yanbing; (CA)
Agent: BATTISON WILLIAMS DUPUIS; P.O. Box 28006 1795 Henderson Hwy, Winnipeg, Manitoba R2G 4E9 (CA)
Priority Data:
60/699,871 18.07.2005 US
Title (EN) PEPTIDE-BASED CYTOKINE VACCINES IN THE TREATMENT OF AUTOIMMUNE AND INFLAMMATORY DISEASES
(FR) VACCINS ANTI-CYTOKINES A BASE DE PEPTIDES DANS LE TRAITEMENT DE MALADIES AUTO-IMMUNES ET INFLAMMATOIRES
Abstract: front page image
(EN)Methods and materials involved in the development of peptide-based cytokine vaccines for treatment of autoimmune and inflammatory diseases are herein described. These cytokines include tumour necrosis factor alpha (TNF&agr; ), interferon gamma (IFNϝ ), interleukin (IL) 1, 2, 6, 10, 12, 15, 18 and their receptors. In the invention, using TNF&agr; as an example, the selected TNF&agr; peptide is fused to a carrier protein, hepatitis B core antigen (HBcAg), forming a fusion protein - chimeric HBcAg - that is presented as virus-like particles. Administration of the vaccine without adjuvant induces high titers of autoantibodies, which neutralize self-TNF&agr; that is increased in a number of diseases.
(FR)La présente invention a trait à des procédés et des substances impliqués dans le développement de vaccins anti-cytokines basés sur des peptides pour le traitement de maladies auto-immunes et inflammatoires. Ces cytokines comprennent le facteur alpha de la nécrose tumorale (TNFa ), l'interféron gamma (IFN? ), l'interleukine (IL) 1, 2, 6, 10, 12, 15, 18 et leurs récepteurs. Dans l'invention, utilisant le TNFa comme un exemple, le peptide TNFa sélectionné est fusionné à une protéine support, l'antigène du noyau de l'hépatite B (HBcAg), formant une protéine hybride - le HbcAg chimèrique-, qui se présente sous la forme de particules de type viral. L'administration du vaccin sans adjuvant induit des titres élevés d'anticorps, qui neutralisent le TNFa autonome qui s'accroît dans une pluralité de maladies.
Designated States: AE, AG, AL, AM, AT, AU, AZ, BA, BB, BG, BR, BW, BY, BZ, CA, CH, CN, CO, CR, CU, CZ, DE, DK, DM, DZ, EC, EE, EG, ES, FI, GB, GD, GE, GH, GM, HN, HR, HU, ID, IL, IN, IS, JP, KE, KG, KM, KN, KP, KR, KZ, LA, LC, LK, LR, LS, LT, LU, LV, LY, MA, MD, MG, MK, MN, MW, MX, MZ, NA, NG, NI, NO, NZ, OM, PG, PH, PL, PT, RO, RS, RU, SC, SD, SE, SG, SK, SL, SM, SY, TJ, TM, TN, TR, TT, TZ, UA, UG, US, UZ, VC, VN, ZA, ZM, ZW.
African Regional Intellectual Property Organization (BW, GH, GM, KE, LS, MW, MZ, NA, SD, SL, SZ, TZ, UG, ZM, ZW)
Eurasian Patent Organization (AM, AZ, BY, KG, KZ, MD, RU, TJ, TM)
European Patent Office (AT, BE, BG, CH, CY, CZ, DE, DK, EE, ES, FI, FR, GB, GR, HU, IE, IS, IT, LT, LU, LV, MC, NL, PL, PT, RO, SE, SI, SK, TR)
African Intellectual Property Organization (BF, BJ, CF, CG, CI, CM, GA, GN, GQ, GW, ML, MR, NE, SN, TD, TG).
Publication Language: English (EN)
Filing Language: English (EN)