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Machine translation
1. (WO2007009208) POLY(ETHYLENE GLOCOL) MODIFIED HUMAN GM-CSF WITH INCREASED BIOLOGICAL ACTIVITY
Latest bibliographic data on file with the International Bureau   

Pub. No.:    WO/2007/009208    International Application No.:    PCT/CA2006/000885
Publication Date: 25.01.2007 International Filing Date: 02.06.2006
IPC:
C07K 14/535 (2006.01), A61K 47/30 (2006.01), A61K 38/19 (2006.01), A61K 47/48 (2006.01)
Applicants: CANGENE CORPORATION [CA/CA]; 155 Innovation Drive, Winnipeg, Manitoba R3T 5Y3 (CA) (For All Designated States Except US).
LEE, Darin [CA/CA]; (CA) (For US Only).
STEWART, Don [CA/CA]; (CA) (For US Only).
TSVETNITSKY, Vadim [CA/CA]; (CA) (For US Only)
Inventors: LEE, Darin; (CA).
STEWART, Don; (CA).
TSVETNITSKY, Vadim; (CA)
Agent: BATTISON WILLIAMS DUPUIS; PO Box 28006, 1795 Henderson Hwy, Winnipeg, Manitoba R2G 4E9 (CA)
Priority Data:
60/686,430 02.06.2005 US
Title (EN) POLY(ETHYLENE GLOCOL) MODIFIED HUMAN GM-CSF WITH INCREASED BIOLOGICAL ACTIVITY
(FR) GM-CSF HUMAIN MODIFIE AU POLY(ETHYLENE GLYCOL) QUI PRESENTE UNE ACTIVITE BIOLOGIQUE ACCRUE
Abstract: front page image
(EN)The present invention provides a full length, non-glycosylated human GM-CSF polypeptide having a single polyethylene glycol molecule covalently attached through an N-terminal amino acid. According to the present invention, the human GM-CSF polypeptide with the attached polyethylene glycol molecule has an unexpectedly increased ability to stimulate the replication of cells in culture compared to the non-modified GM-CSF molecule. This increased ability to stimulate cell division in culture is reflected in neutrophil-increasing activity in an animal model.
(FR)L'invention concerne un polypeptide du GM-CSF humain pleine longueur, non glycosylé, qui comporte une seule molécule de polyéthylène glycol fixée de manière covalente par l'intermédiaire d'un acide aminé N-terminal. Selon l'invention, ce polypeptide du GM-CSF humain auquel est fixée la molécule de polyéthylène glycol présente, de façon inattendue, une capacité accrue de stimulation de la réplication de cellules en culture par rapport à la molécule de GM-CSF non modifiée. Cette capacité accrue de stimuler la division cellulaire en culture se manifeste par l'activité accrue des neutrophiles dans un modèle animal.
Designated States: AE, AG, AL, AM, AT, AU, AZ, BA, BB, BG, BR, BW, BY, BZ, CA, CH, CN, CO, CR, CU, CZ, DE, DK, DM, DZ, EC, EE, EG, ES, FI, GB, GD, GE, GH, GM, HR, HU, ID, IL, IN, IS, JP, KE, KG, KM, KN, KP, KR, KZ, LC, LK, LR, LS, LT, LU, LV, LY, MA, MD, MG, MK, MN, MW, MX, MZ, NA, NG, NI, NO, NZ, OM, PG, PH, PL, PT, RO, RU, SC, SD, SE, SG, SK, SL, SM, SY, TJ, TM, TN, TR, TT, TZ, UA, UG, US, UZ, VC, VN, YU, ZA, ZM, ZW.
African Regional Intellectual Property Organization (BW, GH, GM, KE, LS, MW, MZ, NA, SD, SL, SZ, TZ, UG, ZM, ZW)
Eurasian Patent Organization (AM, AZ, BY, KG, KZ, MD, RU, TJ, TM)
European Patent Office (AT, BE, BG, CH, CY, CZ, DE, DK, EE, ES, FI, FR, GB, GR, HU, IE, IS, IT, LT, LU, LV, MC, NL, PL, PT, RO, SE, SI, SK, TR)
African Intellectual Property Organization (BF, BJ, CF, CG, CI, CM, GA, GN, GQ, GW, ML, MR, NE, SN, TD, TG).
Publication Language: English (EN)
Filing Language: English (EN)