WIPO logo
Mobile | Deutsch | Español | Français | 日本語 | 한국어 | Português | Русский | 中文 | العربية |
PATENTSCOPE

Search International and National Patent Collections
World Intellectual Property Organization
Search
 
Browse
 
Translate
 
Options
 
News
 
Login
 
Help
 
Machine translation
1. (WO2007009201) PROCESS TO OBTAIN SYNTHETIC AND SEMI-SYNTHETIC LIGNAN DERIVATIVES, THEIR ANTIPARASITIC ACTIVITIES AND CORRESPONDING PHARMACEUTICAL FORMULATIONS, INCLUDING THE THERAPEUTIC METHOD USING SAID LIGNAN FOR THE TREATMENT OF PARASITOSIS
Latest bibliographic data on file with the International Bureau   

Pub. No.:    WO/2007/009201    International Application No.:    PCT/BR2006/000144
Publication Date: 25.01.2007 International Filing Date: 14.07.2006
IPC:
C07D 407/10 (2006.01), C07D 407/14 (2006.01)
Applicants: FUNDAÇÃO DE AMPARO À PESQUISA DO ESTADO DE SÃO PAULO [BR/BR]; Rua Pio XI, 1500, Alto Da Lapa, São Paulo - Sp (BR) (For All Designated States Except US).
ASSOCIAÇÃO CULTURAL E EDUCACIONAL DE FRANCA - ACEFRAN [BR/BR]; Av. Dr. Armando Salles de Oliveira, nº 201, Parque Universitário, Franca - Sp (BR) (For All Designated States Except US).
SILVA, Márcio Luis Andrade e [BR/BR]; (BR) (For US Only).
SILVA, Rosangela da [BR/BR]; (BR) (For US Only).
RODRIGUES, Vanderlei [BR/BR]; (BR) (For US Only).
PEREIRA JÚNIOR, Olavo dos Santos [BR/BR]; (BR) (For US Only).
SILVA FILHO, Ademar Alves da [BR/BR]; (BR) (For US Only).
DONATE, Paulo Marcos [BR/BR]; (BR) (For US Only).
ALBUQUERQUE, Sérgio [BR/BR]; (BR) (For US Only).
BASTOS, Jairo Kenupp [BR/BR]; (BR) (For US Only)
Inventors: SILVA, Márcio Luis Andrade e; (BR).
SILVA, Rosangela da; (BR).
RODRIGUES, Vanderlei; (BR).
PEREIRA JÚNIOR, Olavo dos Santos; (BR).
SILVA FILHO, Ademar Alves da; (BR).
DONATE, Paulo Marcos; (BR).
ALBUQUERQUE, Sérgio; (BR).
BASTOS, Jairo Kenupp; (BR)
Agent: ADVOCACIA PIETRO ARIBONI S/C; Rua Guararapes, 1909 - 7º andar, Brooklin Novo, 04561-004 São Paulo - SP (BR)
Priority Data:
PI 0503951-7 15.07.2005 BR
Title (EN) PROCESS TO OBTAIN SYNTHETIC AND SEMI-SYNTHETIC LIGNAN DERIVATIVES, THEIR ANTIPARASITIC ACTIVITIES AND CORRESPONDING PHARMACEUTICAL FORMULATIONS, INCLUDING THE THERAPEUTIC METHOD USING SAID LIGNAN FOR THE TREATMENT OF PARASITOSIS
(FR) PROCEDE PERMETTANT D'OBTENIR DES DERIVES SYNTHETIQUES ET SEMI-SYNTHETIQUES DE LIGNANES, LEURS ACTIVITES ANTIPARASITAIRES, PREPARATIONS PHARMACEUTIQUES CORRESPONDANTES, ET METHODES THERAPEUTIQUES UTILISANT LESDITS LIGNANES POUR TRAITER LA PARASITOSE
Abstract: front page image
(EN)The invention refers to a process to obtain synthetic and semi-synthetic derivatives of lignans, especially dibenzylbutyrolactonic, tetrahydrofuranic, aryltetralynic, furofuranic and dibenzocyclooctanic lignans obtained by means of partial synthesis and/or full synthesis or also by isolation from plant extracts. It refers to a process to obtain synthetic and semi-synthetic derivatives of (-)-cubebin, such as: (-)-O-acetylcubebin; (-)-O-methylcubebin; (-)-O-N,N-(dimethylamino-ethyl)-cubebin; (-)-hinokinin; (-)-6,6’-dinitroinokinine; (-)-O-benzylcubebin; (-)-6,6'-diaminoinokinin, (-)-6,6’-dinitroinokinin, as well as to obtain dibenzocyclooctanic lignans from dibenzylbutyrolactoinic lignans by means of structural modifications in the positions 7, 7’, 8, 8’, 9’ and in the aromatic rings (introduction and/or substitution of functional groups such as: -OH, -CO2H, -CO2CH3, -NO2, -NH2, -OCH3, -OAc, -SO2CH3, -SO2NH2, prenyl and halogens). The invention also refers to a therapeutic method, since the substances described are used in the manufacture of medicine that presents antiparasitic activity.
(FR)La présente invention se rapporte à un procédé permettant d'obtenir des dérivés synthétiques et semi-synthétiques de lignanes, en particulier de lignanes dibenzylbutyrolactoniques, tétrahydrofuraniques, aryltétralyniques, furofuraniques et dibenzocyclooctaniques, qui sont obtenus par synthèse partielle et/ou totale ou également par isolation à partir d'extraits végétaux. L'invention se rapporte aussi à un procédé permettant d'obtenir des dérivés synthétiques et semi-synthétiques de la (-)-cubébine, tels que : la (-)-O-acétylcubebine ; la (-)-O-méthylcubébine ; la (-)-O-N,N-(diméthylamino-éthyl)-cubébine ; la (-)-hinokinine ; la (-)-6,6'-dinitroinokinine ; la (-)-O-benzylcubébine ; la (-)-6,6'-diaminoinokinine ; et la (-)-6,6'-dinitroinokinine. L'invention permet également d'obtenir des lignanes dibenzocyclooctaniques à partir de lignanes dibenzylbutyrolactoiniques, à l'aide de modifications structurelles aux positions 7, 7', 8, 8', 9' et dans les cycles aromatiques (introduction et/ou substitution de groupes fonctionnels tels que -: -OH, -CO2H, -CO2CH3, -NO2, -NH2, -OCH3, -OAc, -SO2CH3, -SO2NH2, prényle et halogènes). L'invention a également trait à une méthode thérapeutique, lesdites substances pouvant servir à fabriquer un médicament qui présente une activité antiparasitaire.
Designated States: AE, AG, AL, AM, AT, AU, AZ, BA, BB, BG, BR, BW, BY, BZ, CA, CH, CN, CO, CR, CU, CZ, DE, DK, DM, DZ, EC, EE, EG, ES, FI, GB, GD, GE, GH, GM, HN, HR, HU, ID, IL, IN, IS, JP, KE, KG, KM, KN, KP, KR, KZ, LA, LC, LK, LR, LS, LT, LU, LV, LY, MA, MD, MG, MK, MN, MW, MX, MZ, NA, NG, NI, NO, NZ, OM, PG, PH, PL, PT, RO, RS, RU, SC, SD, SE, SG, SK, SL, SM, SY, TJ, TM, TN, TR, TT, TZ, UA, UG, US, UZ, VC, VN, ZA, ZM, ZW.
African Regional Intellectual Property Organization (BW, GH, GM, KE, LS, MW, MZ, NA, SD, SL, SZ, TZ, UG, ZM, ZW)
Eurasian Patent Organization (AM, AZ, BY, KG, KZ, MD, RU, TJ, TM)
European Patent Office (AT, BE, BG, CH, CY, CZ, DE, DK, EE, ES, FI, FR, GB, GR, HU, IE, IS, IT, LT, LU, LV, MC, NL, PL, PT, RO, SE, SI, SK, TR)
African Intellectual Property Organization (BF, BJ, CF, CG, CI, CM, GA, GN, GQ, GW, ML, MR, NE, SN, TD, TG).
Publication Language: English (EN)
Filing Language: English (EN)