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1. (WO2007009147) HOMOGEMCITABINES
Latest bibliographic data on file with the International Bureau

Pub. No.: WO/2007/009147 International Application No.: PCT/AT2006/000308
Publication Date: 25.01.2007 International Filing Date: 20.07.2006
IPC:
C07H 19/073 (2006.01) ,A61K 31/7068 (2006.01)
C CHEMISTRY; METALLURGY
07
ORGANIC CHEMISTRY
H
SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
19
Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro derivatives thereof
02
sharing nitrogen
04
Heterocyclic radicals containing only nitrogen as ring hetero atom
06
Pyrimidine radicals
073
with 2-deoxyribosyl as the saccharide radical
A HUMAN NECESSITIES
61
MEDICAL OR VETERINARY SCIENCE; HYGIENE
K
PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
31
Medicinal preparations containing organic active ingredients
70
Carbohydrates; Sugars; Derivatives thereof
7042
Compounds having saccharide radicals and heterocyclic rings
7052
having nitrogen as a ring hetero atom, e.g. nucleosides, nucleotides
706
containing six-membered rings with nitrogen as a ring hetero atom
7064
containing condensed or non-condensed pyrimidines
7068
having oxo groups directly attached to the pyrimidine ring, e.g. cytidine, cytidylic acid
Applicants:
PHARMACON-FORSCHUNG UND BERATUNG GMBH [AT/AT]; Brunnwies 73 A-4780 Brunnenthal, AT (AllExceptUS)
NOE, Christian, R. [AT/AT]; AT (UsOnly)
JASIC, Muhamed [BA/AT]; AT (UsOnly)
KOLLMANN, Hermann [AT/AT]; AT (UsOnly)
SAADAT, Karmin [AT/AT]; AT (UsOnly)
Inventors:
NOE, Christian, R.; AT
JASIC, Muhamed; AT
KOLLMANN, Hermann; AT
SAADAT, Karmin; AT
Agent:
SONN & PARTNER PATENTANWÄLTE; Riemergasse 14 A-1010 Wien, AT
Priority Data:
A 1224/200520.07.2005AT
Title (DE) HOMOGEMCITABINE
(EN) HOMOGEMCITABINES
(FR) HOMOGEMCITABINES
Abstract:
(DE) Die vorliegende Erfindung betrifft Homogemcitabine der allgemeinen Formel (2) mit der in Anspruch 1 angegebenen Bedeutungen der Substituenten, Verfahren zu ihrer Herstellung, ihre Verwendung zur Herstellung des Wirkstoffes Gemcitabin und ihre Verwendung zur Herstellung von Arzneimitteln zur Behandlung proliferativer Erkrankungen. Weiters betrifft die vorliegende Erfindung neue Zwischenverbindungen, wie sie im erfindungsgemäßen Verfahren Verwendung finden.
(EN) The invention relates to homogemcitabines of general formula (2), with the meanings for the substituents as given in claim 1, method for production thereof, use for the production of the active agent gemcitabin and the use thereof for the production of medicaments for the treatment of proliferative diseases. The invention further relates to novel intermediates, as used in the inventive method.
(FR) L'invention concerne des homogemcitabines de formule (2), les substituants ayant les significations indiquées à la revendication 1, des procédés pour les réaliser, leur utilisation pour produire la matière active gemcitabine et leur utilisation pour réaliser des médicaments destinés au traitement de maladies prolifératives. La présente invention porte également sur des nouveaux composés intermédiaires tels qu'ils sont utilisés selon le procédé de l'invention.
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Designated States: AE, AG, AL, AM, AT, AU, AZ, BA, BB, BG, BR, BW, BY, BZ, CA, CH, CN, CO, CR, CU, CZ, DE, DK, DM, DZ, EC, EE, EG, ES, FI, GB, GD, GE, GH, GM, HN, HR, HU, ID, IL, IN, IS, JP, KE, KG, KM, KN, KP, KR, KZ, LA, LC, LK, LR, LS, LT, LU, LV, LY, MA, MD, MG, MK, MN, MW, MX, MZ, NA, NG, NI, NO, NZ, OM, PG, PH, PL, PT, RO, RS, RU, SC, SD, SE, SG, SK, SL, SM, SY, TJ, TM, TN, TR, TT, TZ, UA, UG, US, UZ, VC, VN, ZA, ZM, ZW
African Regional Intellectual Property Organization (ARIPO) (BW, GH, GM, KE, LS, MW, MZ, NA, SD, SL, SZ, TZ, UG, ZM, ZW)
Eurasian Patent Organization (AM, AZ, BY, KG, KZ, MD, RU, TJ, TM)
European Patent Office (AT, BE, BG, CH, CY, CZ, DE, DK, EE, ES, FI, FR, GB, GR, HU, IE, IS, IT, LT, LU, LV, MC, NL, PL, PT, RO, SE, SI, SK, TR)
African Intellectual Property Organization (BF, BJ, CF, CG, CI, CM, GA, GN, GQ, GW, ML, MR, NE, SN, TD, TG)
Publication Language: German (DE)
Filing Language: German (DE)
Also published as:
RSP-2009/0407MXMX/a/2008/000815KR1020080043312EP1904511BRPI0614004US20080249119
CN101243101CA2615356PT1904511AU2006272424DK1904511IN875/DELNP/2008