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1. (WO2007009146) SUBSTITUTED 1-PHENYL IMIDAZOLES AS COX-I INHIBITORS
Latest bibliographic data on file with the International Bureau

Pub. No.: WO/2007/009146 International Application No.: PCT/AT2006/000307
Publication Date: 25.01.2007 International Filing Date: 20.07.2006
IPC:
C07D 233/56 (2006.01) ,C07D 233/64 (2006.01) ,A61K 31/4164 (2006.01) ,A61P 9/00 (2006.01)
C CHEMISTRY; METALLURGY
07
ORGANIC CHEMISTRY
D
HETEROCYCLIC COMPOUNDS
233
Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings
54
having two double bonds between ring members or between ring members and non-ring members
56
with only hydrogen atoms or radicals containing only hydrogen and carbon atoms, attached to ring carbon atoms
C CHEMISTRY; METALLURGY
07
ORGANIC CHEMISTRY
D
HETEROCYCLIC COMPOUNDS
233
Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings
54
having two double bonds between ring members or between ring members and non-ring members
64
with substituted hydrocarbon radicals attached to ring carbon atoms, e.g. histidine
A HUMAN NECESSITIES
61
MEDICAL OR VETERINARY SCIENCE; HYGIENE
K
PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
31
Medicinal preparations containing organic active ingredients
33
Heterocyclic compounds
395
having nitrogen as a ring hetero atom, e.g. guanethidine, rifamycins
41
having five-membered rings with two or more ring hetero atoms, at least one of which is nitrogen, e.g. tetrazole
4164
1,3-Diazoles
A HUMAN NECESSITIES
61
MEDICAL OR VETERINARY SCIENCE; HYGIENE
P
SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
9
Drugs for disorders of the cardiovascular system
Applicants:
UNIVERSITÄT WIEN [AT/AT]; Dr. Karl Lueger-Ring 1 A-1010 Wien, AT (AllExceptUS)
ERKER, Thomas [AT/AT]; AT (UsOnly)
HANDLER, Norbert [AT/AT]; AT (UsOnly)
LANGHAMMER, Ingo [AT/AT]; AT (UsOnly)
Inventors:
ERKER, Thomas; AT
HANDLER, Norbert; AT
LANGHAMMER, Ingo; AT
Agent:
SCHWARZ, Albin ; Wipplingerstrasse 32/22 A-1010 Wien, AT
Priority Data:
A 1237/200522.07.2005AT
Title (DE) SUBSTITUIERTE 1-PHENYL-IMIDAZOLE ALS COX-I-INHIBITOREN
(EN) SUBSTITUTED 1-PHENYL IMIDAZOLES AS COX-I INHIBITORS
(FR) 1-PHENYLE-IMIDAZOLES SUBSTITUES EN TANT QU'INHIBITEURS DE COX-I
Abstract:
(DE) Die Erfindung betrifft Verbindungen der allgemeinen Formel (I) wobei R1 ein Rest gemäß Formel (IIa) oder (IIb) ist, wobei n = 1, 2 oder 3, und R2 Wasserstoff, C1-C4-AlkyI, C1-C4-Alkyloxy, C1-C4-Alkylthio oder C1-C4- Alkylsulfonyl ist. Diese Verbindungen wirken als selektive COX-I-Inhibitoren.
(EN) The invention relates to compounds of general formula (I), wherein R1 represents a radical of formula (IIa) or (IIb), in which n = 1, 2 or 3, and R2 represents hydrogen, C1-C4 alkyI, C1-C4 alkyloxy, C1-C4 alkylthio, or C1-C4 alkylsulfonyl. Said compounds act as selective COX-I inhibitors.
(FR) L'invention concerne des composés de formule (I), R1 étant un groupe selon la formule (IIa) ou (IIb), sachant que n = 1, 2 ou 3 et R2 désigne hydrogène, alkyle C1-C4, alkyloxy C1-C4, alkylthio C1-C4 ou alkylsulfonyle C1-C4. Ces composés agissent comme inhibiteurs sélectifs de COX-I.
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Designated States: AE, AG, AL, AM, AT, AU, AZ, BA, BB, BG, BR, BW, BY, BZ, CA, CH, CN, CO, CR, CU, CZ, DE, DK, DM, DZ, EC, EE, EG, ES, FI, GB, GD, GE, GH, GM, HN, HR, HU, ID, IL, IN, IS, JP, KE, KG, KM, KN, KP, KR, KZ, LA, LC, LK, LR, LS, LT, LU, LV, LY, MA, MD, MG, MK, MN, MW, MX, MZ, NA, NG, NI, NO, NZ, OM, PG, PH, PL, PT, RO, RS, RU, SC, SD, SE, SG, SK, SL, SM, SY, TJ, TM, TN, TR, TT, TZ, UA, UG, US, UZ, VC, VN, ZA, ZM, ZW
African Regional Intellectual Property Organization (ARIPO) (BW, GH, GM, KE, LS, MW, MZ, NA, SD, SL, SZ, TZ, UG, ZM, ZW)
Eurasian Patent Organization (AM, AZ, BY, KG, KZ, MD, RU, TJ, TM)
European Patent Office (AT, BE, BG, CH, CY, CZ, DE, DK, EE, ES, FI, FR, GB, GR, HU, IE, IS, IT, LT, LU, LV, MC, NL, PL, PT, RO, SE, SI, SK, TR)
African Intellectual Property Organization (BF, BJ, CF, CG, CI, CM, GA, GN, GQ, GW, ML, MR, NE, SN, TD, TG)
Publication Language: German (DE)
Filing Language: German (DE)