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Machine translation
1. (WO2007009143) METHOD FOR PRODUCING NEBIVOLOL
Latest bibliographic data on file with the International Bureau   

Pub. No.:    WO/2007/009143    International Application No.:    PCT/AT2006/000303
Publication Date: 25.01.2007 International Filing Date: 17.07.2006
IPC:
C07D 311/58 (2006.01), C07F 7/18 (2006.01)
Applicants: PHARMACON - FORSCHUNG UND BERATUNG GMBH [AT/AT]; Riglergasse 4, A-1180 Wien (AT) (For All Designated States Except US).
NOE, Christian, R. [AT/AT]; (AT) (For US Only).
JASIC, Muhamed [--/AT]; (AT) (For US Only).
KOLLMANN, Hermann [--/AT]; (AT) (For US Only).
LACHMANN, Bodo [--/DE]; (DE) (For US Only)
Inventors: NOE, Christian, R.; (AT).
JASIC, Muhamed; (AT).
KOLLMANN, Hermann; (AT).
LACHMANN, Bodo; (DE)
Agent: BEER, Manfred; Lindengasse 8, A-1070 Wien (AT)
Priority Data:
A1214/2005 19.07.2005 AT
Title (DE) VERFAHREN ZUR HERSTELLUNG NEBIVOLOL
(EN) METHOD FOR PRODUCING NEBIVOLOL
(FR) PROCEDE DE PRODUCTION DE NEBIVOLOL
Abstract: front page image
(DE)Gegenstand der Erfindung ist ein Verfahren zur Herstellung des razernischen Wirkstoffes Nebivolol, vorzugsweise als Hydrochlorid gemäß Formel (I) bei welchem diastereomere Cyanhydrine der allgemeinen Formel (II) hergestellt, getrennt und die getrennten Diastereomere nach einer Transformation, vorzugsweise einer teilweisen oder vollen Reduktion der Cyanogruppe oder einer Pinner-Verseifung, miteinander gekoppelt werden.
(EN)The invention relates to a method for producing the racemic active ingredient Nebivolol, preferably in the form of the hydrochloride of formula (1), according to which diastereomer cyanhydrins of general formula (2) are produced and separated, and the separated diastereomers are coupled together following a transformation, preferably a partial or full reduction of the cyano group or a Pinner saponification.
(FR)L'invention concerne un procédé permettant de produire le principe actif racémique Nébivolol, selon lequel des cyanhydrines diastéréomères sont produites, séparées et les diastéréomères séparés sont à nouveau accouplés, après une transformation, de préférence une réduction partielle ou complète du groupe cyano ou une saponification de Pinner.
Designated States: AE, AG, AL, AM, AT, AU, AZ, BA, BB, BG, BR, BW, BY, BZ, CA, CH, CN, CO, CR, CU, CZ, DE, DK, DM, DZ, EC, EE, EG, ES, FI, GB, GD, GE, GH, GM, HN, HR, HU, ID, IL, IN, IS, JP, KE, KG, KM, KN, KP, KR, KZ, LA, LC, LK, LR, LS, LT, LU, LV, LY, MA, MD, MG, MK, MN, MW, MX, MZ, NA, NG, NI, NO, NZ, OM, PG, PH, PL, PT, RO, RS, RU, SC, SD, SE, SG, SK, SL, SM, SY, TJ, TM, TN, TR, TT, TZ, UA, UG, US, UZ, VC, VN, ZA, ZM, ZW.
African Regional Intellectual Property Organization (BW, GH, GM, KE, LS, MW, MZ, NA, SD, SL, SZ, TZ, UG, ZM, ZW)
Eurasian Patent Organization (AM, AZ, BY, KG, KZ, MD, RU, TJ, TM)
European Patent Office (AT, BE, BG, CH, CY, CZ, DE, DK, EE, ES, FI, FR, GB, GR, HU, IE, IS, IT, LT, LU, LV, MC, NL, PL, PT, RO, SE, SI, SK, TR)
African Intellectual Property Organization (BF, BJ, CF, CG, CI, CM, GA, GN, GQ, GW, ML, MR, NE, SN, TD, TG).
Publication Language: German (DE)
Filing Language: German (DE)