Search International and National Patent Collections
Some content of this application is unavailable at the moment.
If this situation persists, please contact us atFeedback&Contact
1. (WO2007009094) ANTISENSE ANTIBACTERIAL METHOD AND COMPOUND
Latest bibliographic data on file with the International Bureau

Pub. No.: WO/2007/009094 International Application No.: PCT/US2006/027522
Publication Date: 18.01.2007 International Filing Date: 13.07.2006
IPC:
A61K 31/70 (2006.01) ,C07H 21/02 (2006.01) ,C07H 21/04 (2006.01) ,C12N 5/00 (2006.01) ,C12Q 1/68 (2006.01)
A HUMAN NECESSITIES
61
MEDICAL OR VETERINARY SCIENCE; HYGIENE
K
PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
31
Medicinal preparations containing organic active ingredients
70
Carbohydrates; Sugars; Derivatives thereof
C CHEMISTRY; METALLURGY
07
ORGANIC CHEMISTRY
H
SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
21
Compounds containing two or more mononucleotide units having separate phosphate or polyphosphate groups linked by saccharide radicals of nucleoside groups, e.g. nucleic acids
02
with ribosyl as saccharide radical
C CHEMISTRY; METALLURGY
07
ORGANIC CHEMISTRY
H
SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
21
Compounds containing two or more mononucleotide units having separate phosphate or polyphosphate groups linked by saccharide radicals of nucleoside groups, e.g. nucleic acids
04
with deoxyribosyl as saccharide radical
C CHEMISTRY; METALLURGY
12
BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
N
MICRO-ORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICRO-ORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
5
Undifferentiated human, animal or plant cells, e.g. cell lines; Tissues; Cultivation or maintenance thereof; Culture media therefor
C CHEMISTRY; METALLURGY
12
BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
Q
MEASURING OR TESTING PROCESSES INVOLVING ENZYMES OR MICRO-ORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
1
Measuring or testing processes involving enzymes or micro-organisms; Compositions therefor; Processes of preparing such compositions
68
involving nucleic acids
Applicants:
AVI BIOPHARMA, INC. [US/US]; 4575 S.w. Research Way, Suite 200 Corvallis, OR 97333, US (AllExceptUS)
GELLER, Bruce, L. [US/US]; US (UsOnly)
IVERSEN, Patrick, L. [US/US]; US (UsOnly)
TILLEY, Lucas, D. [US/US]; US (UsOnly)
Inventors:
GELLER, Bruce, L.; US
IVERSEN, Patrick, L.; US
TILLEY, Lucas, D.; US
Agent:
MOHR, Judy, M. ; PERKINS COIE LLP P.o. Box 2168 Menlo Park, CA 94026, US
Priority Data:
60/699,28013.07.2005US
Title (EN) ANTISENSE ANTIBACTERIAL METHOD AND COMPOUND
(FR) COMPOSE ET PROCEDE ANTIBACTERIENS ANTISENS
Abstract:
(EN) An antibacterial antisense conjugate and method of using the same for treating a bacterial infection in a mammalian host are disclosed. The conjugate includes an antisense oligonucleotide conjugated to a carrier peptide that significantly enhances the antibacterial activity of the oligonucleotide. The antisense oligonucleotide contains 10-20 nucleotide bases and has a targeting nucleic acid sequence complementary to a target sequence containing or within 10 bases, in a downstream direction, of the translational start codon of a bacterial mRNA that encodes a bacterial protein essential for bacterial replication, where the compound binds to a target mRNA with a Tm of between 50° to 600C. The carrier peptide is an arginine-rich peptide containing between 6 and 12 amino acids.
(FR) L'invention concerne un conjugué antisens antibactérien et son procédé d'utilisation pour le traitement d'une infection bactérienne chez un hôte mammifère. Le conjugué comprend un oligonucléotide antisens conjugué à un peptide porteur qui accroît sensiblement l'activité antibactérienne de l'oligonucléotide. L'oligonucléotide antisens contient 10-20 bases nucléotidiques et possède une séquence nucléotidique de ciblage complémentaire d'une séquence cible contenant 10 bases ou comprise dans 10 bases, vers l'aval, du codon initiateur de traduction d'un ARNm bactérien qui code pour une protéine bactérienne essentielle pour la réplication bactérienne, le composé se liant à un ARNm cible à une Tm de 50 à 600 °C. Le peptide porteur est un peptide riche en arginine contenant entre 6 et 12 acides aminés.
Designated States: AE, AG, AL, AM, AT, AU, AZ, BA, BB, BG, BR, BW, BY, BZ, CA, CH, CN, CO, CR, CU, CZ, DE, DK, DM, DZ, EC, EE, EG, ES, FI, GB, GD, GE, GH, GM, HN, HR, HU, ID, IL, IN, IS, JP, KE, KG, KM, KN, KP, KR, KZ, LA, LC, LK, LR, LS, LT, LU, LV, LY, MA, MD, MG, MK, MN, MW, MX, MZ, NA, NG, NI, NO, NZ, OM, PG, PH, PL, PT, RO, RS, RU, SC, SD, SE, SG, SK, SL, SM, SY, TJ, TM, TN, TR, TT, TZ, UA, UG, US, UZ, VC, VN, ZA, ZM, ZW
African Regional Intellectual Property Organization (ARIPO) (BW, GH, GM, KE, LS, MW, MZ, NA, SD, SL, SZ, TZ, UG, ZM, ZW)
Eurasian Patent Organization (AM, AZ, BY, KG, KZ, MD, RU, TJ, TM)
European Patent Office (AT, BE, BG, CH, CY, CZ, DE, DK, EE, ES, FI, FR, GB, GR, HU, IE, IS, IT, LT, LU, LV, MC, NL, PL, PT, RO, SE, SI, SK, TR)
African Intellectual Property Organization (BF, BJ, CF, CG, CI, CM, GA, GN, GQ, GW, ML, MR, NE, SN, TD, TG)
Publication Language: English (EN)
Filing Language: English (EN)
Also published as:
EP1915161CA2614191AU2006267051