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1. (WO2007009081) A HEXAVALENT BOVINE ROTAVIRUS REASSORTANT COMPOSITION DESIGNED FOR USE IN DEVELOPING COUNTRIES
Latest bibliographic data on file with the International Bureau

Pub. No.: WO/2007/009081 International Application No.: PCT/US2006/027444
Publication Date: 18.01.2007 International Filing Date: 07.07.2006
IPC:
A61K 39/15 (2006.01)
A HUMAN NECESSITIES
61
MEDICAL OR VETERINARY SCIENCE; HYGIENE
K
PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
39
Medicinal preparations containing antigens or antibodies
12
Viral antigens
15
Reoviridae, e.g. calf diarrhea virus
Applicants:
THE GOVERNMENT OF THE UNITED STATES OF AMERICA AS REPRESENTED BY THE SECRETARY OF THE DEPARTMENT OF HEALTH AND HUMAN SERVICES [US/US]; 6011 Executive Blvd., Suite 325 National Institutes Of Health, Office Of Technology Transfer Rockville, Maryland 20852-3804, US (AllExceptUS)
KAPIKIAN, Albert Z. [US/US]; US (UsOnly)
SIMONSEN, Lone [US/US]; US (UsOnly)
VESIKARI, Timo [FI/FI]; FI (UsOnly)
HOSHINO, Yasutaka [JP/US]; US (UsOnly)
MORENS, David M. [US/US]; US (UsOnly)
CHANOCK, Robert M. [US/US]; US (UsOnly)
LA MONTAGNE, John R. [US/US]; US (UsOnly)
MURPHY, Brian R. [US/US]; US (UsOnly)
Inventors:
KAPIKIAN, Albert Z.; US
SIMONSEN, Lone; US
VESIKARI, Timo; FI
HOSHINO, Yasutaka; US
MORENS, David M.; US
CHANOCK, Robert M.; US
LA MONTAGNE, John R.; US
MURPHY, Brian R.; US
Agent:
POOR, Brian W. ; Townsend And Townsend And Crew Llp Two Embarcadero Center, 8th Flr. San Francisco, California 94111, US
Priority Data:
60/697,43507.07.2005US
Title (EN) A HEXAVALENT BOVINE ROTAVIRUS REASSORTANT COMPOSITION DESIGNED FOR USE IN DEVELOPING COUNTRIES
(FR) COMPOSITION A ROTAVIRUS BOVIN REASSORTI HEXAVALENT CONÇUE POUR LES PAYS EN DEVELOPPEMENT
Abstract:
(EN) The present invention provides vaccine compositions for protection against human rotaviral disease designed for use in particular areas of the world. Human x bovine reassortant rotavirus comprising each of the four clinically most important VP7 serotypes of human rotavirus are combined with other VP7 serotypes typically found in the area of interest into a multivalent formulation which provides a high degree of infectivity and immunogenicity. Methods and an administration protocol for producing an immunogenic response without producing an increased risk of intussusception are also provided.
(FR) La présente invention concerne des compositions vaccinales de protection contre des affections rotavirales humaines, destinées à des zones particulières du monde. En l'occurrence, on a pris des rotavirus réassortis humains x bovins comprenant chacun des quatre sérotypes VP7 cliniquement les plus important du rotavirus humain, et on les a combiné à d'autres sérotypes VP7 typiques de la zone ciblée, ce qui a donné une formulation multivalente conférant un degré élevé d'infecticité et d'immunogénicité. L'invention concerne également des procédés et un protocole d'administration destinés à la production d'une réponse immunogène sans augmenter les risques d'intussusception.
Designated States: AE, AG, AL, AM, AT, AU, AZ, BA, BB, BG, BR, BW, BY, BZ, CA, CH, CN, CO, CR, CU, CZ, DE, DK, DM, DZ, EC, EE, EG, ES, FI, GB, GD, GE, GH, GM, HN, HR, HU, ID, IL, IN, IS, JP, KE, KG, KM, KN, KP, KR, KZ, LA, LC, LK, LR, LS, LT, LU, LV, LY, MA, MD, MG, MK, MN, MW, MX, MZ, NA, NG, NI, NO, NZ, OM, PG, PH, PL, PT, RO, RS, RU, SC, SD, SE, SG, SK, SL, SM, SY, TJ, TM, TN, TR, TT, TZ, UA, UG, US, UZ, VC, VN, ZA, ZM, ZW
African Regional Intellectual Property Organization (ARIPO) (BW, GH, GM, KE, LS, MW, MZ, NA, SD, SL, SZ, TZ, UG, ZM, ZW)
Eurasian Patent Organization (AM, AZ, BY, KG, KZ, MD, RU, TJ, TM)
European Patent Office (AT, BE, BG, CH, CY, CZ, DE, DK, EE, ES, FI, FR, GB, GR, HU, IE, IS, IT, LT, LU, LV, MC, NL, PL, PT, RO, SE, SI, SK, TR)
African Intellectual Property Organization (BF, BJ, CF, CG, CI, CM, GA, GN, GQ, GW, ML, MR, NE, SN, TD, TG)
Publication Language: English (EN)
Filing Language: English (EN)
Also published as:
US20080292660