Search International and National Patent Collections
Some content of this application is unavailable at the moment.
If this situation persists, please contact us atFeedback&Contact
1. (WO2007009071) METHODS OF DIAGNOSING AND TREATING AN INFLAMMATORY RESPONSE
Latest bibliographic data on file with the International Bureau

Pub. No.: WO/2007/009071 International Application No.: PCT/US2006/027402
Publication Date: 18.01.2007 International Filing Date: 13.07.2006
IPC:
C12Q 1/68 (2006.01) ,A01N 43/04 (2006.01) ,C07H 21/02 (2006.01) ,C12M 1/00 (2006.01)
C CHEMISTRY; METALLURGY
12
BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
Q
MEASURING OR TESTING PROCESSES INVOLVING ENZYMES OR MICRO-ORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
1
Measuring or testing processes involving enzymes or micro-organisms; Compositions therefor; Processes of preparing such compositions
68
involving nucleic acids
A HUMAN NECESSITIES
01
AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
N
PRESERVATION OF BODIES OF HUMANS OR ANIMALS OR PLANTS OR PARTS THEREOF; BIOCIDES, e.g. AS DISINFECTANTS, AS PESTICIDES OR AS HERBICIDES; PEST REPELLANTS OR ATTRACTANTS; PLANT GROWTH REGULATORS
43
Biocides, pest repellants or attractants, or plant growth regulators containing heterocyclic compounds
02
having rings with one or more oxygen or sulfur atoms as the only ring hetero atom
04
with one hetero atom
C CHEMISTRY; METALLURGY
07
ORGANIC CHEMISTRY
H
SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
21
Compounds containing two or more mononucleotide units having separate phosphate or polyphosphate groups linked by saccharide radicals of nucleoside groups, e.g. nucleic acids
02
with ribosyl as saccharide radical
C CHEMISTRY; METALLURGY
12
BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
M
APPARATUS FOR ENZYMOLOGY OR MICROBIOLOGY
1
Apparatus for enzymology or microbiology
Applicants:
BETH ISRAEL DEACONESS MEDICAL CENTER [US/US]; 330 Brookline Avenue Boston, MA 02215, US (AllExceptUS)
AIRD, William, C. [CA/US]; US (UsOnly)
YANO, Kiichiro [JP/US]; US (UsOnly)
Inventors:
AIRD, William, C.; US
YANO, Kiichiro; US
Agent:
BIEKER-BRADY, Kristina; Clark & Elbing LLP 101 Federal Street Boston, MA 02110, US
Priority Data:
60/698,99713.07.2005US
Title (EN) METHODS OF DIAGNOSING AND TREATING AN INFLAMMATORY RESPONSE
(FR) METHODES DE DIAGNOSTIC ET DE TRAITEMENT D'UNE REPONSE INFLAMMATOIRE
Abstract:
(EN) The present invention relates to the discovery that VEGF, P1GF, and sFlt-1 levels are increased in inflammatory response such as in sepsis, severe sepsis, or septic shock. Additionally, the invention provides methods of identifying treatments as well as providing treatments for such an inflammatory response, which include decreasing VEGF or P1GF levels, or increasing sFlt-1 or P1GF levels.
(FR) L'invention concerne la découverte selon laquelle des niveaux de VEGF, P1GF et sFlt-1 sont accrus dans une réponse inflammatoire, telle que la spesie, la sepsie sévère ou le choc spetique. De plus, l'invention concerne des procédés d'identification de traitements, ainsi que des traitements destinés à une telle réponse inflammatoire, consistant à diminuer les niveaux de VEGF ou P1GF ou à augmenter les niveaux de sFlt-1 ou P1GF.
Designated States: AE, AG, AL, AM, AT, AU, AZ, BA, BB, BG, BR, BW, BY, BZ, CA, CH, CN, CO, CR, CU, CZ, DE, DK, DM, DZ, EC, EE, EG, ES, FI, GB, GD, GE, GH, GM, HN, HR, HU, ID, IL, IN, IS, JP, KE, KG, KM, KN, KP, KR, KZ, LA, LC, LK, LR, LS, LT, LU, LV, LY, MA, MD, MG, MK, MN, MW, MX, MZ, NA, NG, NI, NO, NZ, OM, PG, PH, PL, PT, RO, RS, RU, SC, SD, SE, SG, SK, SL, SM, SY, TJ, TM, TN, TR, TT, TZ, UA, UG, US, UZ, VC, VN, ZA, ZM, ZW
African Regional Intellectual Property Organization (ARIPO) (BW, GH, GM, KE, LS, MW, MZ, NA, SD, SL, SZ, TZ, UG, ZM, ZW)
Eurasian Patent Organization (AM, AZ, BY, KG, KZ, MD, RU, TJ, TM)
European Patent Office (AT, BE, BG, CH, CY, CZ, DE, DK, EE, ES, FI, FR, GB, GR, HU, IE, IS, IT, LT, LU, LV, MC, NL, PL, PT, RO, SE, SI, SK, TR)
African Intellectual Property Organization (BF, BJ, CF, CG, CI, CM, GA, GN, GQ, GW, ML, MR, NE, SN, TD, TG)
Publication Language: English (EN)
Filing Language: English (EN)
Also published as:
EP1902145JP2009501521US20090197794CN101578376AU2006267097