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1. (WO2007009064) METHODS FOR THE TREATMENT OF AUTOIMMUNE DISORDERS USING IMMUNOSUPPRESSIVE MONOCLONAL ANTIBODIES WITH REDUCED TOXICITY
Latest bibliographic data on file with the International Bureau

Pub. No.: WO/2007/009064 International Application No.: PCT/US2006/027386
Publication Date: 18.01.2007 International Filing Date: 11.07.2006
IPC:
A61K 39/395 (2006.01) ,A61P 37/02 (2006.01)
A HUMAN NECESSITIES
61
MEDICAL OR VETERINARY SCIENCE; HYGIENE
K
PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
39
Medicinal preparations containing antigens or antibodies
395
Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum
A HUMAN NECESSITIES
61
MEDICAL OR VETERINARY SCIENCE; HYGIENE
P
SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
37
Drugs for immunological or allergic disorders
02
Immunomodulators
Applicants:
MACROGENICS, INC. [US/US]; 1500 East Gude Drive Rockville, MD 20850-5307, US (AllExceptUS)
KOENIG, Scott [US/US]; US (UsOnly)
WILDER, Ronald [US/US]; US (UsOnly)
BONVINI, Ezio [US/US]; US (UsOnly)
JOHNSON, Leslie, S. [US/US]; US (UsOnly)
Inventors:
KOENIG, Scott; US
WILDER, Ronald; US
BONVINI, Ezio; US
JOHNSON, Leslie, S.; US
Agent:
MARGARET B. BRIVANLOU PH.D.; King & Spalding, LLP 1185 Avenue of The Americas New York, 10036-4003, US
Priority Data:
60/698,51711.07.2005US
Title (EN) METHODS FOR THE TREATMENT OF AUTOIMMUNE DISORDERS USING IMMUNOSUPPRESSIVE MONOCLONAL ANTIBODIES WITH REDUCED TOXICITY
(FR) METHODES DE TRAITEMENT DE TROUBLES AUTO-IMMUNS AU MOYEN D'ANTICORPS MONOCLONAUX IMMUNOSUPPRESSEURS A TOXICITE REDUITE
Abstract:
(EN) The present invention provides methods of treating, preventing or ameliorating the symptoms of T cell-mediated immunological diseases, particularly autoimmune diseases, through the use of anti-CD3 antibodies. In particular, the methods of the invention provide for administration of antibodies that specifically bind the epsilon subunit within the human CD3 complex. Such antibodies modulate the T cell receptor/alloantigen interaction and, thus, regulate the T cell mediated cytotoxicity associated with autoimmune disorders. Additionally, the invention provides for modification of the anti-CD3 antibodies such that they exhibit reduced or eliminated effector function and T cell activation as compared to non- modified anti-CD3 antibodies.
(FR) L'invention concerne des méthodes de traitement, de prévention ou d'amélioration des symptômes de maladies immunologiques induites par les lymphocytes T, notamment des maladies auto-immunes, au moyen d'anticorps anti-CD3. Plus précisément, les méthodes selon l'invention consistent à administrer des anticorps se liant de manière spécifique à la sous-unité epsilon dans le complexe humain CD3. De tels anticorps modulent l'interaction récepteur/allo-antigène des lymphocytes T et, régulent, par conséquent, la cytotoxicité induite par les lymphocytes T associée à des troubles auto-immuns. De plus, l'invention concerne la modification des anticorps anti-CD3 consistant à les modifier de manière qu'ils présentent une fonction de l'effecteur réduite ou pas de fonction et une activation des lymphocytes T comparativement à des anticorps anti-CD3 non modifiés.
Designated States: AE, AG, AL, AM, AT, AU, AZ, BA, BB, BG, BR, BW, BY, BZ, CA, CH, CN, CO, CR, CU, CZ, DE, DK, DM, DZ, EC, EE, EG, ES, FI, GB, GD, GE, GH, GM, HN, HR, HU, ID, IL, IN, IS, JP, KE, KG, KM, KN, KP, KR, KZ, LA, LC, LK, LR, LS, LT, LU, LV, LY, MA, MD, MG, MK, MN, MW, MX, MZ, NA, NG, NI, NO, NZ, OM, PG, PH, PL, PT, RO, RS, RU, SC, SD, SE, SG, SK, SL, SM, SY, TJ, TM, TN, TR, TT, TZ, UA, UG, US, UZ, VC, VN, ZA, ZM, ZW
African Regional Intellectual Property Organization (ARIPO) (BW, GH, GM, KE, LS, MW, MZ, NA, SD, SL, SZ, TZ, UG, ZM, ZW)
Eurasian Patent Organization (AM, AZ, BY, KG, KZ, MD, RU, TJ, TM)
European Patent Office (AT, BE, BG, CH, CY, CZ, DE, DK, EE, ES, FI, FR, GB, GR, HU, IE, IS, IT, LT, LU, LV, MC, NL, PL, PT, RO, SE, SI, SK, TR)
African Intellectual Property Organization (BF, BJ, CF, CG, CI, CM, GA, GN, GQ, GW, ML, MR, NE, SN, TD, TG)
Publication Language: English (EN)
Filing Language: English (EN)
Also published as:
IL188592SG163615EP1904105JP2009500457SG177944EP2497496
JP2013005798CA2614640SG10201504917PAU2006267090AU2013200924IN1147/DELNP/2008