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1. (WO2007008994) GLUTAMATE AGGRECANASE INHIBITORS
Latest bibliographic data on file with the International Bureau   

Pub. No.:    WO/2007/008994    International Application No.:    PCT/US2006/027066
Publication Date: 18.01.2007 International Filing Date: 11.07.2006
Chapter 2 Demand Filed:    26.07.2007    
IPC:
C07C 237/22 (2006.01), C07C 235/84 (2006.01), C07D 317/58 (2006.01), C07D 333/24 (2006.01), C07D 213/56 (2006.01), C07D 277/30 (2006.01), C07C 323/41 (2006.01), C07C 259/06 (2006.01), C07C 237/42 (2006.01), C07C 231/16 (2006.01), A61K 31/166 (2006.01), A61K 31/36 (2006.01), A61K 31/381 (2006.01), A61K 31/4409 (2006.01), A61K 31/426 (2006.01)
Applicants: WYETH [US/US]; Five Giralda Farms, Madison, NJ 07940 (US) (For All Designated States Except US).
SUM, Phaik-Eng [CA/US]; (US) (For US Only).
HOW, David, Brian [CA/US]; (US) (For US Only).
SABATINI, Joshua, James [US/US]; (US) (For US Only).
XIANG, Jason, Shaoyun [US/US]; (US) (For US Only).
FEYFANT, Eric [FR/US]; (US) (For US Only).
TAM, Steve YikKai [US/US]; (US) (For US Only).
SKOTNICKI, Jerauld, Stanley [US/US]; (US) (For US Only).
MANSOUR, Tarek, Suhayl [CA/US]; (US) (For US Only)
Inventors: SUM, Phaik-Eng; (US).
HOW, David, Brian; (US).
SABATINI, Joshua, James; (US).
XIANG, Jason, Shaoyun; (US).
FEYFANT, Eric; (US).
TAM, Steve YikKai; (US).
SKOTNICKI, Jerauld, Stanley; (US).
MANSOUR, Tarek, Suhayl; (US)
Agent: BARNHARD, Elizabeth, M.; Wyeth, Patent Law Department, Five Giralda Farms, Madison, NJ 07940 (US)
Priority Data:
60/697,590 11.07.2005 US
Title (EN) GLUTAMATE AGGRECANASE INHIBITORS
(FR) INHIBITEURS DE GLUTAMATE AGGRECANASE
Abstract: front page image
(EN)The present invention relates to compounds of the formula (I), which are modulators of metalloproteinase activity. and pharmaceutically acceptable salts thereof, wherein W is -C(O)-, -OC(O)-, -NHC(O)-, -C(O)O-, Or -C(O)NH-; R1 is phenyl, heteroaryl, biphenyl, bicyciic aryi, tricyclic aryl, bicyclic heteroaryl. or tricyclic heteroaryl, each optionally substituted with one or more of R5 or R6, and when Ri is substituted with more than one of R5 or Re, the substituents can be identical or different; R2 is hydrogen, (C1 -C6) alkyl, (C2-C6) alkenyl, (C2-C6) alkynyl, -(CH2)nR11 , -OH, or -0-(C1-C6) alkyl; R3 is -CO2H, -CONH2, -CONHOH, -CONHSO2R7, tetrazole, -SO2NHR7, -SO3H, -PO(OH)NH2, -PO(OH)OR7, -CONHR7, -COOR7, an acid mimetic group, or a 5 or 6-membered heterocycloalkyl or heteroaryl containing 1 to 4 heteroatoms selected from O, N, S; R4 is -CO2H, -CONH2, -(CH2)nOR7, or -CONR9R10;
(FR)Cette invention concerne des modulateurs d'activité de métalloprotéinase.
Designated States: AE, AG, AL, AM, AT, AU, AZ, BA, BB, BG, BR, BW, BY, BZ, CA, CH, CN, CO, CR, CU, CZ, DE, DK, DM, DZ, EC, EE, EG, ES, FI, GB, GD, GE, GH, GM, HN, HR, HU, ID, IL, IN, IS, JP, KE, KG, KM, KN, KP, KR, KZ, LA, LC, LK, LR, LS, LT, LU, LV, LY, MA, MD, MG, MK, MN, MW, MX, MZ, NA, NG, NI, NO, NZ, OM, PG, PH, PL, PT, RO, RS, RU, SC, SD, SE, SG, SK, SL, SM, SY, TJ, TM, TN, TR, TT, TZ, UA, UG, US, UZ, VC, VN, ZA, ZM, ZW.
African Regional Intellectual Property Organization (BW, GH, GM, KE, LS, MW, MZ, NA, SD, SL, SZ, TZ, UG, ZM, ZW)
Eurasian Patent Organization (AM, AZ, BY, KG, KZ, MD, RU, TJ, TM)
European Patent Office (AT, BE, BG, CH, CY, CZ, DE, DK, EE, ES, FI, FR, GB, GR, HU, IE, IS, IT, LT, LU, LV, MC, NL, PL, PT, RO, SE, SI, SK, TR)
African Intellectual Property Organization (BF, BJ, CF, CG, CI, CM, GA, GN, GQ, GW, ML, MR, NE, SN, TD, TG).
Publication Language: English (EN)
Filing Language: English (EN)