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Pub. No.:    WO/2007/008937    International Application No.:    PCT/US2006/026971
Publication Date: 18.01.2007 International Filing Date: 11.07.2006
C07K 14/47 (2006.01), C07K 14/575 (2006.01), A61P 3/10 (2006.01), A61P 9/12 (2006.01), A61P 3/04 (2006.01)
Applicants: XENCOR [US/US]; 111 West Lemon Avenue, Monrovia, CA 91016 (US) (For All Designated States Except US).
ZALEVSKY, Jonathan [US/US]; (US) (For US Only).
NGUYEN, Duc-Hanh, Thi [US/US]; (US) (For US Only).
MOORE, Gregory, L. [US/US]; (US) (For US Only).
EZHEVSKY, Sergei, A. [RU/US]; (US) (For US Only).
DESJARLAIS, John, R. [US/US]; (US) (For US Only).
CHIRINO, Arthur, J. [US/US]; (US) (For US Only).
CASH, Darian [US/US]; (US) (For US Only).
BERNETT, Matthew, J. [US/US]; (US) (For US Only)
Inventors: ZALEVSKY, Jonathan; (US).
NGUYEN, Duc-Hanh, Thi; (US).
MOORE, Gregory, L.; (US).
EZHEVSKY, Sergei, A.; (US).
CHIRINO, Arthur, J.; (US).
CASH, Darian; (US).
BERNETT, Matthew, J.; (US)
Agent: MCCLURE, Lawrence, J.; HOGAN & HARTSON L.L.P., 1999 Avenue of the Stars, Suite 1400, Los Angeles, CA 90067 (US)
Priority Data:
60/698,358 11.07.2005 US
60/720,768 26.09.2005 US
60/733,137 02.11.2005 US
11/328,901 09.01.2006 US
PCT/US2006/000627 09.01.2006 US
60/777,825 01.03.2006 US
60/781,509 09.03.2006 US
60/790,220 07.04.2006 US
11/421,055 30.05.2006 US
11/421,059 30.05.2006 US
11/421,060 30.05.2006 US
11/421,061 30.05.2006 US
11/421,062 30.05.2006 US
Abstract: front page image
(EN)An adiponectin variant comprising one or more amino acid modifications relative to a corresponding parent adiponectin, wherein the solubility of said variant is improved by at least 3-fold relative to residues 110-244 of SEQ ID NO:1 (human adiponectin). Said adiponectin variant may not comprise residues 1-100 relative to SEQ ID NO:1.
(FR)L'invention concerne un variant d'adiponectine comportant une ou plusieurs modifications d'acides aminés par rapport à une adiponectine parente correspondante, la solubilité de ce variant étant au moins 3 fois meilleure que celle de résidus 110-244 de SEQ ID NO:1 (adiponectine humaine). Ce variant d'adiponectine peut ne pas contenir de résidus 1-100 par rapport à SEQ ID NO:1.
Designated States: AE, AG, AL, AM, AT, AU, AZ, BA, BB, BG, BR, BW, BY, BZ, CA, CH, CN, CO, CR, CU, CZ, DE, DK, DM, DZ, EC, EE, EG, ES, FI, GB, GD, GE, GH, GM, HN, HR, HU, ID, IL, IN, IS, JP, KE, KG, KM, KN, KP, KR, KZ, LA, LC, LK, LR, LS, LT, LU, LV, LY, MA, MD, MG, MK, MN, MW, MX, MZ, NA, NG, NI, NO, NZ, OM, PG, PH, PL, PT, RO, RS, RU, SC, SD, SE, SG, SK, SL, SM, SY, TJ, TM, TN, TR, TT, TZ, UA, UG, US, UZ, VC, VN, ZA, ZM, ZW.
African Regional Intellectual Property Organization (BW, GH, GM, KE, LS, MW, MZ, NA, SD, SL, SZ, TZ, UG, ZM, ZW)
Eurasian Patent Organization (AM, AZ, BY, KG, KZ, MD, RU, TJ, TM)
European Patent Office (AT, BE, BG, CH, CY, CZ, DE, DK, EE, ES, FI, FR, GB, GR, HU, IE, IS, IT, LT, LU, LV, MC, NL, PL, PT, RO, SE, SI, SK, TR)
African Intellectual Property Organization (BF, BJ, CF, CG, CI, CM, GA, GN, GQ, GW, ML, MR, NE, SN, TD, TG).
Publication Language: English (EN)
Filing Language: English (EN)