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1. (WO2007008904) TARGETING POLY-GAMMA-GLUTAMIC ACID TO TREAT STAPHYLOCOCCUS EPIDERMIDIS AND RELATED INFECTIONS
Latest bibliographic data on file with the International Bureau   

Pub. No.:    WO/2007/008904    International Application No.:    PCT/US2006/026900
Publication Date: 18.01.2007 International Filing Date: 10.07.2006
IPC:
A61K 39/085 (2006.01), A61P 31/04 (2006.01)
Applicants: THE GOVERNMENT OF THE UNITED STATES OF AMERICA as represented by THE SECRETARY OF THE DEPARTMENT OF HEALTH AND HUMAN SERVICES [US/US]; National Institutes of Health, Office of Technology Transfer, 6011 Executive Boulevard, Suite 325, Rockville, MD 20852-3804 (US) (For All Designated States Except US).
OTTO, Michael [DE/US]; (US) (For US Only).
KOCIANOVA, Stanislava [SK/US]; (US) (For US Only).
VUONG, Cuong [DE/US]; (US) (For US Only).
VOYICH, Jovanka [US/US]; (US) (For US Only).
YAO, Yufeng [CN/US]; (US) (For US Only).
FISCHER, Elizabeth [US/US]; (US) (For US Only).
DE LEO, Frank [US/US]; (US) (For US Only)
Inventors: OTTO, Michael; (US).
KOCIANOVA, Stanislava; (US).
VUONG, Cuong; (US).
VOYICH, Jovanka; (US).
YAO, Yufeng; (US).
FISCHER, Elizabeth; (US).
DE LEO, Frank; (US)
Agent: NOONAN, William, D.; Klarquist Sparkman, LLP, One World Trade Center, Suite 1600, 121 SW Salmon Street, Portland, OR 97204 (US)
Priority Data:
60/697,646 08.07.2005 US
Title (EN) TARGETING POLY-GAMMA-GLUTAMIC ACID TO TREAT STAPHYLOCOCCUS EPIDERMIDIS AND RELATED INFECTIONS
(FR) CIBLAGE DE L'ACIDE POLY-GAMMA-GLUTAMIQUE EN VUE DE TRAITER LES INFECTIONS PROVOQUEES PAR LE STAPHYLOCOCCUS EPIDERMIDIS ET LES INFECTIONS APPARENTEES
Abstract: front page image
(EN)Immunogenic compositions and methods for eliciting an immune response against S. epiderrnidis and other related staphylococci are provided. The immunogenic compositions can include immunogenic conjugates of poly-ϝ-glutamic acid (such as ϝDLPGA) polypeptides of S. epidermidis, or related staphylococci that express a ϝPGA polypeptide. The ϝPGA conjugates elicit an effective immune response against S. epidermidis, or other staphylococci, in subjects to which the conjugates are administered. A method of treating an infection caused by a Staphylococcus organism that expresses cap genes is also disclosed. The method can include selecting a subject who is at risk of or has been diagonosed with the infection by the Staphylococcus organism which expresses ϝPGA from the cap genes. Further, the expression of a ϝPGA polypeptide by the organism can then be altered.
(FR)La présente invention concerne des compositions et des méthodes immunogènes d'élicitation d'une réponse immunitaire contre S. epiderrnidis et d'autres staphylocoques apparentés. Les compositions immunogènes peuvent comprendre des conjugués immunogènes de polypeptides d'acide poly-?-glutamique (tel que ?DLPGA) de S. epidermidis ou des staphylocoques apparentés qui expriment un polypeptide ?PGA. Les conjugués ?PGA élicitent une réponse immunitaire efficace contre S. epidermidis ou d'autres staphylocoques, chez des individus auxquels les conjugués ont été administrés. Une méthode de traitement d'une infection provoquée par un organisme Staphylococcus qui exprime des gènes cap est également présentée. La méthode peut consister à sélectionner un individu qui présente un risque d'infection ou qui a été diagnostiqué comme porteur de l'infection provoquée par l'organisme Staphylococcus qui exprime ?PGA à partir des gènes cap. L'expression d'un polypeptide ?PGA par l'organisme peut ensuite être altérée.
Designated States: AE, AG, AL, AM, AT, AU, AZ, BA, BB, BG, BR, BW, BY, BZ, CA, CH, CN, CO, CR, CU, CZ, DE, DK, DM, DZ, EC, EE, EG, ES, FI, GB, GD, GE, GH, GM, HN, HR, HU, ID, IL, IN, IS, JP, KE, KG, KM, KN, KP, KR, KZ, LA, LC, LK, LR, LS, LT, LU, LV, LY, MA, MD, MG, MK, MN, MW, MX, MZ, NA, NG, NI, NO, NZ, OM, PG, PH, PL, PT, RO, RS, RU, SC, SD, SE, SG, SK, SL, SM, SY, TJ, TM, TN, TR, TT, TZ, UA, UG, US, UZ, VC, VN, ZA, ZM, ZW.
African Regional Intellectual Property Organization (BW, GH, GM, KE, LS, MW, MZ, NA, SD, SL, SZ, TZ, UG, ZM, ZW)
Eurasian Patent Organization (AM, AZ, BY, KG, KZ, MD, RU, TJ, TM)
European Patent Office (AT, BE, BG, CH, CY, CZ, DE, DK, EE, ES, FI, FR, GB, GR, HU, IE, IS, IT, LT, LU, LV, MC, NL, PL, PT, RO, SE, SI, SK, TR)
African Intellectual Property Organization (BF, BJ, CF, CG, CI, CM, GA, GN, GQ, GW, ML, MR, NE, SN, TD, TG).
Publication Language: English (EN)
Filing Language: English (EN)