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1. (WO2007008848) MONOMETHYLVALINE COMPOUNDS HAVING PHENYLALANINE CARBOXY MODIFICATIONS AT THE C-TERMINUS
Latest bibliographic data on file with the International Bureau

Pub. No.: WO/2007/008848 International Application No.: PCT/US2006/026809
Publication Date: 18.01.2007 International Filing Date: 07.07.2006
IPC:
A61K 39/395 (2006.01) ,A61K 38/00 (2006.01) ,C07K 2/00 (2006.01)
A HUMAN NECESSITIES
61
MEDICAL OR VETERINARY SCIENCE; HYGIENE
K
PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
39
Medicinal preparations containing antigens or antibodies
395
Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum
A HUMAN NECESSITIES
61
MEDICAL OR VETERINARY SCIENCE; HYGIENE
K
PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
38
Medicinal preparations containing peptides
C CHEMISTRY; METALLURGY
07
ORGANIC CHEMISTRY
K
PEPTIDES
2
Peptides of undefined number of amino acids; Derivatives thereof
Applicants:
SEATTLE GENETICS, INC. [US/US]; 21823 - 30th Dr. SE Bothell, Washington 98021, US (AllExceptUS)
DORONINA, Svetlana O. [RU/US]; US (UsOnly)
KLINE, Toni Beth [US/US]; US (UsOnly)
JEFFREY, Scott [US/US]; US (UsOnly)
SENTER, Peter D. [US/US]; US (UsOnly)
MEYER, Damon [US/US]; US (UsOnly)
Inventors:
DORONINA, Svetlana O.; US
KLINE, Toni Beth; US
JEFFREY, Scott; US
SENTER, Peter D.; US
MEYER, Damon; US
Priority Data:
60/697,72807.07.2005US
Title (EN) MONOMETHYLVALINE COMPOUNDS HAVING PHENYLALANINE CARBOXY MODIFICATIONS AT THE C-TERMINUS
(FR) COMPOSES DE MONOMETHYLVALINE PRESENTANT DES MODIFICATIONS CARBOXY PHENYLALANINE A LA TERMINAISON C
Abstract:
(EN) Auristatin peptide analogs of MeVal-Val-Dil-Dap-Phe (MMAF) having a carboxylic acid equivalent at the C-terminal phenylalanine were prepared and attached to ligands through various linkers, including maleimidocaproyl-val-cit-PAB. The resulting ligand drug conjugates were active in vitro and in vivo.
(FR) L'invention concerne des analogues de peptides d'auristatine de MeVal-Val-Dil-Dap-Phe (MMAF) ayant un acide carboxylique équivalent à la phénylalanine C-terminale que l'on prépare et que l'on fixe à des ligands par divers lieurs, y compris le maléimidocaproyl-val-cit-PAB. Les conjugués médicament ligand obtenus ont présentés une activité in vitro et in vivo.
Designated States: AE, AG, AL, AM, AT, AU, AZ, BA, BB, BG, BR, BW, BY, BZ, CA, CH, CN, CO, CR, CU, CZ, DE, DK, DM, DZ, EC, EE, EG, ES, FI, GB, GD, GE, GH, GM, HN, HR, HU, ID, IL, IN, IS, JP, KE, KG, KM, KN, KP, KR, KZ, LA, LC, LK, LR, LS, LT, LU, LV, LY, MA, MD, MG, MK, MN, MW, MX, MZ, NA, NG, NI, NO, NZ, OM, PG, PH, PL, PT, RO, RS, RU, SC, SD, SE, SG, SK, SL, SM, SY, TJ, TM, TN, TR, TT, TZ, UA, UG, US, UZ, VC, VN, ZA, ZM, ZW
African Regional Intellectual Property Organization (ARIPO) (BW, GH, GM, KE, LS, MW, MZ, NA, SD, SL, SZ, TZ, UG, ZM, ZW)
Eurasian Patent Organization (AM, AZ, BY, KG, KZ, MD, RU, TJ, TM)
European Patent Office (AT, BE, BG, CH, CY, CZ, DE, DK, EE, ES, FI, FR, GB, GR, HU, IE, IS, IT, LT, LU, LV, MC, NL, PL, PT, RO, SE, SI, SK, TR)
African Intellectual Property Organization (BF, BJ, CF, CG, CI, CM, GA, GN, GQ, GW, ML, MR, NE, SN, TD, TG)
Publication Language: English (EN)
Filing Language: English (EN)
Also published as:
US20090111756