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1. (WO2007008821) METHODS AND COMPOSITIONS FOR TREATING OPHTHALMIC CONDITIONS VIA SERUM RETINOL, SERUM RETINOL BINDING PROTEIN (RBP), AND/OR SERUM RETINOL-RBP MODULATION
Latest bibliographic data on file with the International Bureau

Pub. No.: WO/2007/008821 International Application No.: PCT/US2006/026770
Publication Date: 18.01.2007 International Filing Date: 10.07.2006
IPC:
A61K 31/07 (2006.01) ,A61K 35/44 (2006.01) ,A01N 31/04 (2006.01)
A HUMAN NECESSITIES
61
MEDICAL OR VETERINARY SCIENCE; HYGIENE
K
PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
31
Medicinal preparations containing organic active ingredients
045
Hydroxy compounds, e.g. alcohols; Salts thereof, e.g. alcoholates
07
Retinol compounds, e.g. vitamin A
A HUMAN NECESSITIES
61
MEDICAL OR VETERINARY SCIENCE; HYGIENE
K
PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
35
Medicinal preparations containing material or reaction products thereof with undetermined constitution
12
Materials from mammals or birds
44
Eyes; Vessels; Umbilical cord
A HUMAN NECESSITIES
01
AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
N
PRESERVATION OF BODIES OF HUMANS OR ANIMALS OR PLANTS OR PARTS THEREOF; BIOCIDES, e.g. AS DISINFECTANTS, AS PESTICIDES OR AS HERBICIDES; PEST REPELLANTS OR ATTRACTANTS; PLANT GROWTH REGULATORS
31
Biocides, pest repellants or attractants, or plant growth regulators containing organic oxygen or sulfur compounds
04
Oxygen or sulfur attached to an aliphatic side chain of a carbocyclic ring system
Applicants:
SIRION THERAPEUTICS, INC. [US/US]; 11408 Sorrento Valley Road San Diego, CA 92121, US (AllExceptUS)
WIDDER, Ken [US/US]; US (UsOnly)
LICHTER, Jay [US/US]; US (UsOnly)
MATA, Nathan, L. [US/US]; US (UsOnly)
Inventors:
WIDDER, Ken; US
LICHTER, Jay; US
MATA, Nathan, L.; US
Agent:
HOSTETLER, Michael, J. ; Wilson Sonsini Goodrich & Rosati 650 Page Mill Road Palo Alto, CA 94304-1050, US
Priority Data:
60/698,51211.07.2005US
Title (EN) METHODS AND COMPOSITIONS FOR TREATING OPHTHALMIC CONDITIONS VIA SERUM RETINOL, SERUM RETINOL BINDING PROTEIN (RBP), AND/OR SERUM RETINOL-RBP MODULATION
(FR) METHODES ET COMPOSITIONS DE TRAITEMENT DE MALADIES OPHTALMIQUES PAR LA MODULATION DU RETINOL SERIQUE, DE LA PROTEINE DE LIAISON DE RETINOL SERIQUE (RBP) ET / OU DE LA RBP / DU RETINOL SERIQUE
Abstract:
(EN) Compounds that reduce serum retinol, serum RBP, and/or serum retinol-RBP levels may be used to treat ophthalmic conditions associated with the overproduction of waste products that accumulate during the course of the visual cycle. We describe methods and compositions using such compounds and their derivatives to treat, for example, the macular degenerations and dystrophies or to alleviate symptoms associated with such ophthalmic conditions. Such compounds and their derivatives may be used as single agent therapy or in combination with other agents or therapies.
(FR) Composés qui réduisent les taux de rétinol sérique, de protéine de liaison de rétinol (RBP) sérique et / ou de RBP / rétinol sérique et qui peuvent être utilisés pour traiter des maladies ophtalmiques associées avec la production excessive de déchets qui s'accumulent pendant le cycle visuel. La présente invention concerne des méthodes et des compositions à base de ces composés et de leurs dérivés pour traiter, par exemple, la dégénérescence maculaire et les dystrophies ou pour soulager les symptômes associés à ces maladies ophtalmiques. Ces composés et leurs dérivés peuvent être utilisés en tant qu'agent thérapeutique unique ou en combinaison avec d'autres agents ou thérapies.
front page image
Designated States: AE, AG, AL, AM, AT, AU, AZ, BA, BB, BG, BR, BW, BY, BZ, CA, CH, CN, CO, CR, CU, CZ, DE, DK, DM, DZ, EC, EE, EG, ES, FI, GB, GD, GE, GH, GM, HN, HR, HU, ID, IL, IN, IS, JP, KE, KG, KM, KN, KP, KR, KZ, LA, LC, LK, LR, LS, LT, LU, LV, LY, MA, MD, MG, MK, MN, MW, MX, MZ, NA, NG, NI, NO, NZ, OM, PG, PH, PL, PT, RO, RS, RU, SC, SD, SE, SG, SK, SL, SM, SY, TJ, TM, TN, TR, TT, TZ, UA, UG, US, UZ, VC, VN, ZA, ZM, ZW
African Regional Intellectual Property Organization (ARIPO) (BW, GH, GM, KE, LS, MW, MZ, NA, SD, SL, SZ, TZ, UG, ZM, ZW)
Eurasian Patent Organization (AM, AZ, BY, KG, KZ, MD, RU, TJ, TM)
European Patent Office (AT, BE, BG, CH, CY, CZ, DE, DK, EE, ES, FI, FR, GB, GR, HU, IE, IS, IT, LT, LU, LV, MC, NL, PL, PT, RO, SE, SI, SK, TR)
African Intellectual Property Organization (BF, BJ, CF, CG, CI, CM, GA, GN, GQ, GW, ML, MR, NE, SN, TD, TG)
Publication Language: English (EN)
Filing Language: English (EN)
Also published as:
NO20080718NZ564841MXMX/a/2008/000064KR1020080055790IL188528VN19741
EP1904043ZA2008/00844JP2009500455CN101252924CA2614627EA200800291
AU2006268374