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1. WO2007008712 - ANTI-ALPHA V BETA 6 ANTIBODIES AND USES THEREOF

Publication Number WO/2007/008712
Publication Date 18.01.2007
International Application No. PCT/US2006/026598
International Filing Date 10.07.2006
Chapter 2 Demand Filed 04.09.2007
IPC
C CHEMISTRY; METALLURGY
12
BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
P
FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
21
Preparation of peptides or proteins
08
Monoclonal antibodies
C CHEMISTRY; METALLURGY
07
ORGANIC CHEMISTRY
K
PEPTIDES
16
Immunoglobulins, e.g. monoclonal or polyclonal antibodies
A HUMAN NECESSITIES
61
MEDICAL OR VETERINARY SCIENCE; HYGIENE
K
PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
39
Medicinal preparations containing antigens or antibodies
395
Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum
G PHYSICS
01
MEASURING; TESTING
N
INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
33
Investigating or analysing materials by specific methods not covered by groups G01N1/-G01N31/131
48
Biological material, e.g. blood, urine; Haemocytometers
50
Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
53
Immunoassay; Biospecific binding assay; Materials therefor
G PHYSICS
01
MEASURING; TESTING
N
INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
33
Investigating or analysing materials by specific methods not covered by groups G01N1/-G01N31/131
48
Biological material, e.g. blood, urine; Haemocytometers
50
Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
53
Immunoassay; Biospecific binding assay; Materials therefor
574
for cancer
C CHEMISTRY; METALLURGY
12
BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
P
FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
21
Preparation of peptides or proteins
02
having a known sequence of two or more amino acids, e.g. glutathione
04
Cyclic or bridged peptides or polypeptides, e.g. bacitracin
C CHEMISTRY; METALLURGY
07
ORGANIC CHEMISTRY
H
SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
21
Compounds containing two or more mononucleotide units having separate phosphate or polyphosphate groups linked by saccharide radicals of nucleoside groups, e.g. nucleic acids
04
with deoxyribosyl as saccharide radical
C12P 21/08 (2006.01)
C07K 16/00 (2006.01)
A61K 39/395 (2006.01)
G01N 33/53 (2006.01)
G01N 33/574 (2006.01)
C12P 21/04 (2006.01)
CPC
A61K 2039/505
A61K 2039/545
C07K 16/2839
C07K 16/30
C07K 2317/24
C07K 2317/41
Applicants
  • BIOGEN IDEC MA INC. [US/US]; 14 Cambridge Center Cambridge, MA 02142, US (AllExceptUS)
  • VIOLETTE, Shelia [US/US]; US (UsOnly)
  • KOOPMAN, Louise, A. [NL/US]; US (UsOnly)
  • SIMON, Kenneth, J. [US/US]; US (UsOnly)
  • WEINREB, Paul, H. [US/US]; US (UsOnly)
  • VAN VLIJMEN, Herman [NL/NL]; NL (UsOnly)
  • SALDANHA, Jose [GB/GB]; GB (UsOnly)
  • LUGOVSKOY, Alexey, A. [RU/US]; US (UsOnly)
Inventors
  • VIOLETTE, Shelia; US
  • KOOPMAN, Louise, A.; US
  • SIMON, Kenneth, J.; US
  • WEINREB, Paul, H.; US
  • VAN VLIJMEN, Herman; NL
  • SALDANHA, Jose; GB
  • LUGOVSKOY, Alexey, A.; US
Agents
  • DEL BUONO, Brian, J. ; Sterne, Kessler, Goldstein & Fox P.L.L.C. 1100 New York Avenue, N.W. Washington, DC 20005, US
Priority Data
60/697,44208.07.2005US
60/773,31015.02.2006US
Publication Language English (EN)
Filing Language English (EN)
Designated States
Title
(EN) ANTI-ALPHA V BETA 6 ANTIBODIES AND USES THEREOF
(FR) ANTICORPS ANTI-ALPHA V BETA 6 ET LEURS UTILISATIONS
Abstract
(EN)
The present invention is in the fields of cell biology, immunology and oncology. Specifically, the invention relates to humanized antibodies that recognizes v 6 integrins which comprises a variable region of nonhuman origin and at least -a portion of an immunoglobulin of human origin. The invention also relates to processes for their preparation, to pharmaceutical compositions comprising them and to methods of treating various diseases by administering humanized anti- v 6 antibodies. The invention also relates to the identification of differential expression of the integrin avß6 on the surfaces of tumor cells and tissues, the use of this differential expression in determining the metastatic potential of tumor cells, and methods of diagnosis and treatment/prevention of tumor metastasis and for elimination of residual metastatic tumor cells using ligands, particularly antibodies, that bind to integrin avß6.
(FR)
L'invention se rapporte aux domaines de la biologie cellulaire, de l'immunologie et de l'oncologie. Spécifiquement, l'invention concerne des anticorps humanisés reconnaissant des intégrines v 6, comprenant une région variable, d'origine non humaine, et au moins une portion d'une immunoglobuline d'origine humaine. L'invention concerne également des procédés pour leur préparation, des compositions pharmaceutiques les renfermant, ainsi que des procédés de traitement de diverses maladies par administration d'anticorps humanisés anti-v 6. L'invention concerne en outre l'identification de l'expression différentielle de l'intégrine av$g(b)6 sur les surfaces de cellules et de tissus tumoraux, l'utilisation de cette expression différentielle dans la détermination du potentiel métastatique des cellules tumorales, et des procédés de diagnostic et de traitement/prévention des métastases tumorales et de l'élimination des cellules tumorales métastatiques résiduelles au moyen de ligands, en particulier d'anticorps se liant à l'intégrine av$g(b)6.
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