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1. (WO2007008712) ANTI-ALPHA V BETA 6 ANTIBODIES AND USES THEREOF
Latest bibliographic data on file with the International Bureau   

Pub. No.:    WO/2007/008712    International Application No.:    PCT/US2006/026598
Publication Date: 18.01.2007 International Filing Date: 10.07.2006
Chapter 2 Demand Filed:    04.09.2007    
IPC:
C12P 21/08 (2006.01), C07K 16/00 (2006.01), A61K 39/395 (2006.01), G01N 33/53 (2006.01), G01N 33/574 (2006.01), C12P 21/04 (2006.01), C07H 21/04 (2006.01)
Applicants: BIOGEN IDEC MA INC. [US/US]; 14 Cambridge Center, Cambridge, MA 02142 (US) (For All Designated States Except US).
VIOLETTE, Shelia [US/US]; (US) (For US Only).
KOOPMAN, Louise, A. [NL/US]; (US) (For US Only).
SIMON, Kenneth, J. [US/US]; (US) (For US Only).
WEINREB, Paul, H. [US/US]; (US) (For US Only).
VAN VLIJMEN, Herman [NL/NL]; (NL) (For US Only).
SALDANHA, Jose [GB/GB]; (GB) (For US Only).
LUGOVSKOY, Alexey, A. [RU/US]; (US) (For US Only)
Inventors: VIOLETTE, Shelia; (US).
KOOPMAN, Louise, A.; (US).
SIMON, Kenneth, J.; (US).
WEINREB, Paul, H.; (US).
VAN VLIJMEN, Herman; (NL).
SALDANHA, Jose; (GB).
LUGOVSKOY, Alexey, A.; (US)
Agent: DEL BUONO, Brian, J.; Sterne, Kessler, Goldstein & Fox P.L.L.C., 1100 New York Avenue, N.W., Washington, DC 20005 (US)
Priority Data:
60/697,442 08.07.2005 US
60/773,310 15.02.2006 US
Title (EN) ANTI-ALPHA V BETA 6 ANTIBODIES AND USES THEREOF
(FR) ANTICORPS ANTI-ALPHA V BETA 6 ET LEURS UTILISATIONS
Abstract: front page image
(EN)The present invention is in the fields of cell biology, immunology and oncology. Specifically, the invention relates to humanized antibodies that recognizes v 6 integrins which comprises a variable region of nonhuman origin and at least -a portion of an immunoglobulin of human origin. The invention also relates to processes for their preparation, to pharmaceutical compositions comprising them and to methods of treating various diseases by administering humanized anti- v 6 antibodies. The invention also relates to the identification of differential expression of the integrin avß6 on the surfaces of tumor cells and tissues, the use of this differential expression in determining the metastatic potential of tumor cells, and methods of diagnosis and treatment/prevention of tumor metastasis and for elimination of residual metastatic tumor cells using ligands, particularly antibodies, that bind to integrin avß6.
(FR)L'invention se rapporte aux domaines de la biologie cellulaire, de l'immunologie et de l'oncologie. Spécifiquement, l'invention concerne des anticorps humanisés reconnaissant des intégrines v 6, comprenant une région variable, d'origine non humaine, et au moins une portion d'une immunoglobuline d'origine humaine. L'invention concerne également des procédés pour leur préparation, des compositions pharmaceutiques les renfermant, ainsi que des procédés de traitement de diverses maladies par administration d'anticorps humanisés anti-v 6. L'invention concerne en outre l'identification de l'expression différentielle de l'intégrine av$g(b)6 sur les surfaces de cellules et de tissus tumoraux, l'utilisation de cette expression différentielle dans la détermination du potentiel métastatique des cellules tumorales, et des procédés de diagnostic et de traitement/prévention des métastases tumorales et de l'élimination des cellules tumorales métastatiques résiduelles au moyen de ligands, en particulier d'anticorps se liant à l'intégrine av$g(b)6.
Designated States: AE, AG, AL, AM, AT, AU, AZ, BA, BB, BG, BR, BW, BY, BZ, CA, CH, CN, CO, CR, CU, CZ, DE, DK, DM, DZ, EC, EE, EG, ES, FI, GB, GD, GE, GH, GM, HN, HR, HU, ID, IL, IN, IS, JP, KE, KG, KM, KN, KP, KR, KZ, LA, LC, LK, LR, LS, LT, LU, LV, LY, MA, MD, ME, MG, MK, MN, MW, MX, MZ, NA, NG, NI, NO, NZ, OM, PG, PH, PL, PT, RO, RS, RU, SC, SD, SE, SG, SK, SL, SM, SY, TJ, TM, TN, TR, TT, TZ, UA, UG, US, UZ, VC, VN, ZA, ZM, ZW.
African Regional Intellectual Property Organization (BW, GH, GM, KE, LS, MW, MZ, NA, SD, SL, SZ, TZ, UG, ZM, ZW)
Eurasian Patent Organization (AM, AZ, BY, KG, KZ, MD, RU, TJ, TM)
European Patent Office (AT, BE, BG, CH, CY, CZ, DE, DK, EE, ES, FI, FR, GB, GR, HU, IE, IS, IT, LT, LU, LV, MC, NL, PL, PT, RO, SE, SI, SK, TR)
African Intellectual Property Organization (BF, BJ, CF, CG, CI, CM, GA, GN, GQ, GW, ML, MR, NE, SN, TD, TG).
Publication Language: English (EN)
Filing Language: English (EN)