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1. (WO2007008691) USE OF MICROCHIMERIC CELLS IN THE TREATMENT OF MALIGNANCY
Latest bibliographic data on file with the International Bureau

Pub. No.: WO/2007/008691 International Application No.: PCT/US2006/026569
Publication Date: 18.01.2007 International Filing Date: 10.07.2006
IPC:
A61K 35/14 (2006.01) ,A61K 35/12 (2006.01) ,A61P 35/00 (2006.01)
A HUMAN NECESSITIES
61
MEDICAL OR VETERINARY SCIENCE; HYGIENE
K
PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
35
Medicinal preparations containing material or reaction products thereof with undetermined constitution
12
Materials from mammals or birds
14
Blood
A HUMAN NECESSITIES
61
MEDICAL OR VETERINARY SCIENCE; HYGIENE
K
PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
35
Medicinal preparations containing material or reaction products thereof with undetermined constitution
12
Materials from mammals or birds
A HUMAN NECESSITIES
61
MEDICAL OR VETERINARY SCIENCE; HYGIENE
P
SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
35
Antineoplastic agents
Applicants:
WEST PENN ALLEGHENY HEALTH SYSTEM, INC. [US/US]; 4800 Friendship Avenue Pittsburgh, PA 15224, US (AllExceptUS)
Inventors:
SHADDUCK, Richard, K.; US
Agent:
DILMORE, James, G. ; REED SMITH LLP P.O. Box 488 Pittsburgh, PA 15230-0488, US
Priority Data:
60/697,87308.07.2005US
Title (EN) USE OF MICROCHIMERIC CELLS IN THE TREATMENT OF MALIGNANCY
(FR) UTILISATION DE CELLULES MICROCHIMERIQUES DANS LE TRAITEMENT DE MALIGNITE
Abstract:
(EN) Methods and formulations for the treatment of malignancies. Assessment of the incidence and scope of MC in control and cancer populations provides for the development of cellular therapy approaches to hematologic malignancies that are expected to be well tolerated immunologically. Studies will confirm that parous females who display MC are able to tolerate donor cells from their male offspring immunologically. Studies will explore the use of MC offspring donor cells in cellular therapy for the treatment of hematologic and other malignancies.
(FR) La présente invention a trait à des procédés et à des formulations pour le traitement des malignités. Une évaluation de l'incidence et de l'étendue d'un microchimérisme dans des populations témoin et cancéreuses permet de développer des techniques de thérapie cellulaire contre des malignités hématologiques dont une bonne tolérance immunologique est attendue. Des études ont confirmé que des femelles primipares présentant le microchimérisme peuvent présenter une tolérance immunologique pour des cellules donneuses provenant de leur progéniture. Des études explorent l'utilisation de cellules donneuses de progéniture de microchimérisme dans la thérapie cellulaire pour le traitement de malignités hématologiques et d'autres malignités.
Designated States: AE, AG, AL, AM, AT, AU, AZ, BA, BB, BG, BR, BW, BY, BZ, CA, CH, CN, CO, CR, CU, CZ, DE, DK, DM, DZ, EC, EE, EG, ES, FI, GB, GD, GE, GH, GM, HN, HR, HU, ID, IL, IN, IS, JP, KE, KG, KM, KN, KP, KR, KZ, LA, LC, LK, LR, LS, LT, LU, LV, LY, MA, MD, MG, MK, MN, MW, MX, MZ, NA, NG, NI, NO, NZ, OM, PG, PH, PL, PT, RO, RS, RU, SC, SD, SE, SG, SK, SL, SM, SY, TJ, TM, TN, TR, TT, TZ, UA, UG, US, UZ, VC, VN, ZA, ZM, ZW
African Regional Intellectual Property Organization (ARIPO) (BW, GH, GM, KE, LS, MW, MZ, NA, SD, SL, SZ, TZ, UG, ZM, ZW)
Eurasian Patent Organization (AM, AZ, BY, KG, KZ, MD, RU, TJ, TM)
European Patent Office (AT, BE, BG, CH, CY, CZ, DE, DK, EE, ES, FI, FR, GB, GR, HU, IE, IS, IT, LT, LU, LV, MC, NL, PL, PT, RO, SE, SI, SK, TR)
African Intellectual Property Organization (BF, BJ, CF, CG, CI, CM, GA, GN, GQ, GW, ML, MR, NE, SN, TD, TG)
Publication Language: English (EN)
Filing Language: English (EN)