WIPO logo
Mobile | Deutsch | Español | Français | 日本語 | 한국어 | Português | Русский | 中文 | العربية |
PATENTSCOPE

Search International and National Patent Collections
World Intellectual Property Organization
Search
 
Browse
 
Translate
 
Options
 
News
 
Login
 
Help
 
Machine translation
1. (WO2007008548) METHODS AND RELATED COMPOSITIONS FOR TREATING OR PREVENTING OBESITY, INSULIN RESISTANCE DISORDERS, AND MITOCHONDRIAL-ASSOCIATED DISORDERS
Latest bibliographic data on file with the International Bureau   

Pub. No.:    WO/2007/008548    International Application No.:    PCT/US2006/026272
Publication Date: 18.01.2007 International Filing Date: 07.07.2006
IPC:
A61K 31/05 (2006.01), A61P 3/04 (2006.01)
Applicants: SIRTRIS PHARMACEUTICALS, INC. [US/US]; 790 Memorial Drive, Suite 104, Cambridge, MA 02139 (US) (For All Designated States Except US).
MILBURN, Michael [US/US]; (US) (For US Only).
MILNE, Jill [US/US]; (US) (For US Only).
AUWERX, Johan [BE/FR]; (FR) (For US Only).
ARGMANN, Carmen [CA/FR]; (FR) (For US Only).
LAGOUGE, Marie [FR/FR]; (FR) (For US Only).
DIPP, Michelle [US/US]; (US) (For US Only)
Inventors: MILBURN, Michael; (US).
MILNE, Jill; (US).
AUWERX, Johan; (FR).
ARGMANN, Carmen; (FR).
LAGOUGE, Marie; (FR).
DIPP, Michelle; (US)
Agent: VINCENT, Matthew, P.; Fish & Neave IP Group, Ropes & Gray LLP, One International Place, Boston, MA 02110-2624 (US)
Priority Data:
60/697,443 07.07.2005 US
60/736,528 14.11.2005 US
60/753,606 23.12.2005 US
60/783,802 16.03.2006 US
Title (EN) METHODS AND RELATED COMPOSITIONS FOR TREATING OR PREVENTING OBESITY, INSULIN RESISTANCE DISORDERS, AND MITOCHONDRIAL-ASSOCIATED DISORDERS
(FR) METHODES ET COMPOSITIONS ASSOCIEES POUR LE TRAITEMENT OU LA PREVENTION DE L'OBESITE, DE TROUBLES D'INSULINO-RESISTANCE ET DE TROUBLES ASSOCIES AUX MITOCHONDRIES
Abstract: front page image
(EN)Provided herein are methods and compositions for treating or preventing metabolic disorders, such as obesity and diabetes. Methods may comprise modulating the activity or level of a sirtuin, such as SIRTl or Sir2. Exemplary methods comprise contacting a cell with a sirtuin activating compound, such as a flavone, stilbene, flavanone, isoflavone, catechin, chalcone, tannin or anthocyanidin, or an inhibitory compound, such as nicotinamide.
(FR)L'invention concerne des méthodes et des compositions de traitement ou de prévention de troubles métaboliques, tels que l'obésité et le diabète. Ces méthodes peuvent consister à moduler l'activité ou le niveau d'un composé activant la sirtuine, tel que SIRT1 ou Sir2. Des méthodes exemplaires consistent à mettre en contact une cellule avec un composé activant la sirtuine, tel qu'une flavone, un stilbène, une flavanone, une isoflavone, une catéchine, une chalcone, un tannin ou une anthocyanidine, ou un composé inhibiteur, tel que la nicotinamide.
Designated States: AE, AG, AL, AM, AT, AU, AZ, BA, BB, BG, BR, BW, BY, BZ, CA, CH, CN, CO, CR, CU, CZ, DE, DK, DM, DZ, EC, EE, EG, ES, FI, GB, GD, GE, GH, GM, HN, HR, HU, ID, IL, IN, IS, JP, KE, KG, KM, KN, KP, KR, KZ, LA, LC, LK, LR, LS, LT, LU, LV, LY, MA, MD, MG, MK, MN, MW, MX, MZ, NA, NG, NI, NO, NZ, OM, PG, PH, PL, PT, RO, RS, RU, SC, SD, SE, SG, SK, SL, SM, SY, TJ, TM, TN, TR, TT, TZ, UA, UG, US, UZ, VC, VN, ZA, ZM, ZW.
African Regional Intellectual Property Organization (BW, GH, GM, KE, LS, MW, MZ, NA, SD, SL, SZ, TZ, UG, ZM, ZW)
Eurasian Patent Organization (AM, AZ, BY, KG, KZ, MD, RU, TJ, TM)
European Patent Office (AT, BE, BG, CH, CY, CZ, DE, DK, EE, ES, FI, FR, GB, GR, HU, IE, IS, IT, LT, LU, LV, MC, NL, PL, PT, RO, SE, SI, SK, TR)
African Intellectual Property Organization (BF, BJ, CF, CG, CI, CM, GA, GN, GQ, GW, ML, MR, NE, SN, TD, TG).
Publication Language: English (EN)
Filing Language: English (EN)