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1. (WO2007008499) TREATMENT OF CANCER PATIENTS EXHIBITING ACTIVATION OF THE P-GLYCOPROTEIN EFFLUX PUMP MECHANISM
Latest bibliographic data on file with the International Bureau   

Pub. No.:    WO/2007/008499    International Application No.:    PCT/US2006/026035
Publication Date: 18.01.2007 International Filing Date: 30.06.2006
IPC:
G01N 33/53 (2006.01), G01N 33/574 (2006.01), G01N 33/48 (2006.01), G01N 33/566 (2006.01)
Applicants: KANISA PHARMACEUTICALS, INC. [US/US]; 12264 El Camino Real, Suite 300, San Diego, California 92130 (US) (For All Designated States Except US).
SIKIC, Branimir [US/US]; (US) (For US Only).
HOTH, Daniel [US/US]; (US) (For US Only).
SOCKS, David [US/US]; (US) (For US Only).
GLENN, Scott [US/US]; (US) (For US Only).
MARCELLETTI, John [US/US]; (US) (For US Only).
WALSH, Michael, J. [US/US]; (US) (For US Only).
MULTANI, Pratik, S. [US/US]; (US) (For US Only)
Inventors: SIKIC, Branimir; (US).
HOTH, Daniel; (US).
SOCKS, David; (US).
GLENN, Scott; (US).
MARCELLETTI, John; (US).
WALSH, Michael, J.; (US).
MULTANI, Pratik, S.; (US)
Agent: HART, Daniel; Knobbe Martens Olson & Bear LLP, 2040 Main Street, 14th Floor, Irvine, California 92614 (US)
Priority Data:
60/696,913 06.07.2005 US
60/726,827 14.10.2005 US
11/417,984 03.05.2006 US
11/418,323 03.05.2006 US
11/418,399 03.05.2006 US
Title (EN) TREATMENT OF CANCER PATIENTS EXHIBITING ACTIVATION OF THE P-GLYCOPROTEIN EFFLUX PUMP MECHANISM
(FR) TRAITEMENT DE PATIENTS CANCEREUX PRESENTANT UNE ACTIVATION DU MECANISME DE POMPE D'EFFLUX DE LA GLYCOPROTEINE P
Abstract: front page image
(EN)The present invention relates to a method of determining P-glycoprotein expression and/or function for a patient with solid tumors, leukemias, and other malignancies. The invention also relates to using a P-glycoprotein expression and/or function diagnostic in conjunction with methods for treating solid tumors, leukemias, and other malignancies with a chemotherapeutic agent in combination with zosuquidar. The methods are particularly effective in treating acute myelogenous leukemia, metastatic breast cancer, and other cancers expressing P-glycoprotein, wherein the P-glycoprotein expression and/or function is used to select a treatment option for the patient.
(FR)L'invention concerne un procédé permettant de déterminer l'expression et/ou la fonction de la glycoprotéine P chez un patient présentant une tumeur solide, une leucémie ou d'autres tumeurs malignes. L'invention concerne aussi l'utilisation conjointe du diagnostic de l'expression et/ou de la fonction de la glycoprotéine P, et de méthodes de traitement de tumeurs solides, de leucémies et d'autres tumeurs malignes à l'aide d'un agent chimiothérapeutique combiné au zosuquidar. Ces méthodes sont particulièrement efficaces dans le traitement de la leucémie myélogène aiguë, le cancer du sein métastatique et d'autres cancers exprimant la glycoprotéine P, l'expression et/ou la fonction de la glycoprotéine P permettant de choisir une option de traitement pour le patient.
Designated States: AE, AG, AL, AM, AT, AU, AZ, BA, BB, BG, BR, BW, BY, BZ, CA, CH, CN, CO, CR, CU, CZ, DE, DK, DM, DZ, EC, EE, EG, ES, FI, GB, GD, GE, GH, GM, HN, HR, HU, ID, IL, IN, IS, JP, KE, KG, KM, KN, KP, KR, KZ, LA, LC, LK, LR, LS, LT, LU, LV, LY, MA, MD, MG, MK, MN, MW, MX, MZ, NA, NG, NI, NO, NZ, OM, PG, PH, PL, PT, RO, RS, RU, SC, SD, SE, SG, SK, SL, SM, SY, TJ, TM, TN, TR, TT, TZ, UA, UG, US, UZ, VC, VN, ZA, ZM, ZW.
African Regional Intellectual Property Organization (BW, GH, GM, KE, LS, MW, MZ, NA, SD, SL, SZ, TZ, UG, ZM, ZW)
Eurasian Patent Organization (AM, AZ, BY, KG, KZ, MD, RU, TJ, TM)
European Patent Office (AT, BE, BG, CH, CY, CZ, DE, DK, EE, ES, FI, FR, GB, GR, HU, IE, IS, IT, LT, LU, LV, MC, NL, PL, PT, RO, SE, SI, SK, TR)
African Intellectual Property Organization (BF, BJ, CF, CG, CI, CM, GA, GN, GQ, GW, ML, MR, NE, SN, TD, TG).
Publication Language: English (EN)
Filing Language: English (EN)