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1. (WO2007008485) PREVENTION OF CHRONIC REJECTION IN SOLID ORGAN TRANSPLANTATION
Latest bibliographic data on file with the International Bureau

Pub. No.: WO/2007/008485 International Application No.: PCT/US2006/025979
Publication Date: 18.01.2007 International Filing Date: 30.06.2006
IPC:
A01N 63/00 (2006.01) ,A61K 48/00 (2006.01) ,C12N 15/00 (2006.01) ,C12N 15/86 (2006.01)
A HUMAN NECESSITIES
01
AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
N
PRESERVATION OF BODIES OF HUMANS OR ANIMALS OR PLANTS OR PARTS THEREOF; BIOCIDES, e.g. AS DISINFECTANTS, AS PESTICIDES OR AS HERBICIDES; PEST REPELLANTS OR ATTRACTANTS; PLANT GROWTH REGULATORS
63
Biocides, pest repellants or attractants, or plant growth regulators containing micro-organisms, viruses, microbial fungi, animals, e.g. nematodes, or substances produced by, or obtained from micro-organisms, viruses, microbial fungi or animals, e.g. enzymes or fermentates
A HUMAN NECESSITIES
61
MEDICAL OR VETERINARY SCIENCE; HYGIENE
K
PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
48
Medicinal preparations containing genetic material which is inserted into cells of the living body to treat genetic diseases; Gene therapy
C CHEMISTRY; METALLURGY
12
BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
N
MICRO-ORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICRO-ORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
15
Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
C CHEMISTRY; METALLURGY
12
BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
N
MICRO-ORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICRO-ORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
15
Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
09
Recombinant DNA-technology
63
Introduction of foreign genetic material using vectors; Vectors; Use of hosts therefor; Regulation of expression
79
Vectors or expression systems specially adapted for eukaryotic hosts
85
for animal cells
86
Viral vectors
Applicants:
GENZYME COPORATION [US/US]; 500 Kendall Street Cambridge, MA 02142, US (AllExceptUS)
NWAKI, M., Yuichi; US (UsOnly)
PIERCE, Glenn [US/US]; US (UsOnly)
JIANG, Haiyan [US/US]; US (UsOnly)
Inventors:
NWAKI, M., Yuichi; US
PIERCE, Glenn; US
JIANG, Haiyan; US
Agent:
TOUSIGNANT, Jennifer, D. ; Genzyme Corporation 15 Pleasant Street Connector Framingham, MA 01701-9322, US
Priority Data:
60/697,45907.07.2005US
Title (EN) PREVENTION OF CHRONIC REJECTION IN SOLID ORGAN TRANSPLANTATION
(FR) PREVENTION DU REJET CHRONIQUE DANS LA TRANSPLANTATION D'ORGANES SOLIDES
Abstract:
(EN) The present invention relates to the use of recombinant adenoassociated virus (rAAV) vectors to transduce cells of a solid organ to be transplanted with a nucleic acid sequence encoding an immunomodulatory polypeptide, e.g. IL-IO, the expression of which reduces the likelihood of rejection of the transplanted organ by the host immune system. Methods of improving the efficiency of solid organ transplantation by administering rAAV vectors encoding IL-IO to an isolated solid organ prior to transplantation of that organ into a subject are also described. The solid organ to be transduced may be the heart, kidney, liver, pancreatic islet, lung, or intestine.
(FR) La présente invention concerne l'utilisation de vecteurs du virus adéno-associé recombinant (rAAV) pour transduire des cellules d'un organe solide à transplanter avec une séquence d'acide nucléique codant pour un polypeptide immunomodulateur, tel que l'IL-10, dont l'expression réduit le risque de rejet de l'organe transplanté par le système immunitaire hôte. L'invention concerne également des méthodes destinées à augmenter l'efficacité d'une transplantation d'organes solides par administration de vecteurs de rAAV codant pour l'IL-10 dans un organe solide isolé avant la transplantation de cet organe sur un sujet. L'organe solide à transduire peut être un coeur, un rein, un foie, un îlot pancréatique, un poumon ou un intestin.
Designated States: AE, AG, AL, AM, AT, AU, AZ, BA, BB, BG, BR, BW, BY, BZ, CA, CH, CN, CO, CR, CU, CZ, DE, DK, DM, DZ, EC, EE, EG, ES, FI, GB, GD, GE, GH, GM, HN, HR, HU, ID, IL, IN, IS, JP, KE, KG, KM, KN, KP, KR, KZ, LA, LC, LK, LR, LS, LT, LU, LV, LY, MA, MD, MG, MK, MN, MW, MX, MZ, NA, NG, NI, NO, NZ, OM, PG, PH, PL, PT, RO, RS, RU, SC, SD, SE, SG, SK, SL, SM, SY, TJ, TM, TN, TR, TT, TZ, UA, UG, US, UZ, VC, VN, ZA, ZM, ZW
African Regional Intellectual Property Organization (ARIPO) (BW, GH, GM, KE, LS, MW, MZ, NA, SD, SL, SZ, TZ, UG, ZM, ZW)
Eurasian Patent Organization (AM, AZ, BY, KG, KZ, MD, RU, TJ, TM)
European Patent Office (AT, BE, BG, CH, CY, CZ, DE, DK, EE, ES, FI, FR, GB, GR, HU, IE, IS, IT, LT, LU, LV, MC, NL, PL, PT, RO, SE, SI, SK, TR)
African Intellectual Property Organization (BF, BJ, CF, CG, CI, CM, GA, GN, GQ, GW, ML, MR, NE, SN, TD, TG)
Publication Language: English (EN)
Filing Language: English (EN)
Also published as:
MXMX/a/2008/000060IL188561EP1903872BRPI0614056JP2009500417CN101217875
AU2006269487IN434/KOLNP/2008