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1. (WO2007008485) PREVENTION OF CHRONIC REJECTION IN SOLID ORGAN TRANSPLANTATION
Latest bibliographic data on file with the International Bureau   

Pub. No.:    WO/2007/008485    International Application No.:    PCT/US2006/025979
Publication Date: 18.01.2007 International Filing Date: 30.06.2006
IPC:
A01N 63/00 (2006.01), A61K 48/00 (2006.01), C12N 15/00 (2006.01), C12N 15/86 (2006.01)
Applicants: GENZYME COPORATION [US/US]; 500 Kendall Street, Cambridge, MA 02142 (US) (For All Designated States Except US).
NWAKI, M., Yuichi; (US) (For US Only).
PIERCE, Glenn [US/US]; (US) (For US Only).
JIANG, Haiyan [US/US]; (US) (For US Only)
Inventors: NWAKI, M., Yuichi; (US).
PIERCE, Glenn; (US).
JIANG, Haiyan; (US)
Agent: TOUSIGNANT, Jennifer, D.; Genzyme Corporation, 15 Pleasant Street Connector, Framingham, MA 01701-9322 (US)
Priority Data:
60/697,459 07.07.2005 US
Title (EN) PREVENTION OF CHRONIC REJECTION IN SOLID ORGAN TRANSPLANTATION
(FR) PREVENTION DU REJET CHRONIQUE DANS LA TRANSPLANTATION D'ORGANES SOLIDES
Abstract: front page image
(EN)The present invention relates to the use of recombinant adenoassociated virus (rAAV) vectors to transduce cells of a solid organ to be transplanted with a nucleic acid sequence encoding an immunomodulatory polypeptide, e.g. IL-IO, the expression of which reduces the likelihood of rejection of the transplanted organ by the host immune system. Methods of improving the efficiency of solid organ transplantation by administering rAAV vectors encoding IL-IO to an isolated solid organ prior to transplantation of that organ into a subject are also described. The solid organ to be transduced may be the heart, kidney, liver, pancreatic islet, lung, or intestine.
(FR)La présente invention concerne l'utilisation de vecteurs du virus adéno-associé recombinant (rAAV) pour transduire des cellules d'un organe solide à transplanter avec une séquence d'acide nucléique codant pour un polypeptide immunomodulateur, tel que l'IL-10, dont l'expression réduit le risque de rejet de l'organe transplanté par le système immunitaire hôte. L'invention concerne également des méthodes destinées à augmenter l'efficacité d'une transplantation d'organes solides par administration de vecteurs de rAAV codant pour l'IL-10 dans un organe solide isolé avant la transplantation de cet organe sur un sujet. L'organe solide à transduire peut être un coeur, un rein, un foie, un îlot pancréatique, un poumon ou un intestin.
Designated States: AE, AG, AL, AM, AT, AU, AZ, BA, BB, BG, BR, BW, BY, BZ, CA, CH, CN, CO, CR, CU, CZ, DE, DK, DM, DZ, EC, EE, EG, ES, FI, GB, GD, GE, GH, GM, HN, HR, HU, ID, IL, IN, IS, JP, KE, KG, KM, KN, KP, KR, KZ, LA, LC, LK, LR, LS, LT, LU, LV, LY, MA, MD, MG, MK, MN, MW, MX, MZ, NA, NG, NI, NO, NZ, OM, PG, PH, PL, PT, RO, RS, RU, SC, SD, SE, SG, SK, SL, SM, SY, TJ, TM, TN, TR, TT, TZ, UA, UG, US, UZ, VC, VN, ZA, ZM, ZW.
African Regional Intellectual Property Organization (BW, GH, GM, KE, LS, MW, MZ, NA, SD, SL, SZ, TZ, UG, ZM, ZW)
Eurasian Patent Organization (AM, AZ, BY, KG, KZ, MD, RU, TJ, TM)
European Patent Office (AT, BE, BG, CH, CY, CZ, DE, DK, EE, ES, FI, FR, GB, GR, HU, IE, IS, IT, LT, LU, LV, MC, NL, PL, PT, RO, SE, SI, SK, TR)
African Intellectual Property Organization (BF, BJ, CF, CG, CI, CM, GA, GN, GQ, GW, ML, MR, NE, SN, TD, TG).
Publication Language: English (EN)
Filing Language: English (EN)